In terms of appearance, the M50 continues the overall shape and general design of i4, and it has a strong recognition due to the penetrating double kidney grille, three-stage air intake opening and smooth back lines. Compared with the BMW i4, the details of the front enclosure, the rear enclosure and the rim of the M50 model have been upgraded in a sporty way, and more carbon fiber materials have been added to reduce the weight of the car. At the same time, the front grille of the new car is also equipped with the M logo to show its identity. In terms of size, the length, width and height of the new car are 4785/1852/1448mm and the wheelbase is 2856 mm. Sales Tel: 13821856177 Manager Zhang

　　The BMW i4 M50 has heat dissipation openings at the front enclosure and the front fender, and the inside of the rim is equipped with large brake calipers and brake discs. Coming to the rear, the M50 model provides a carbon fiber spoiler and diffuser, which, although not exhausted, is domineering enough.

　　In the rear part, the BMW i4 M50 presents a typical "pear shape", and the diffuser shape surrounded by it makes the whole car look more solid. Generally speaking, the slender column, short front overhang, the door with frameless windows flow smoothly into the rear roof line, which is a perfect coupe-shaped outline.

　　The M50 supports optional M-carbon fiber exterior components, including front air intake, exterior rearview mirror cover, rear side decoration and a new rear spoiler with the same geometric design, which further greatly improves the sports texture of the whole vehicle, not only ensuring elegance, but also revealing a "fierce" momentum.

　　Entering the interior, the interior part of M50 is similar to the layout of the same fuel car, revealing a low-key gorgeous. The M50 is designed with a double screen inside. The left half is a 12.3-inch LCD instrument with an obvious M logo on the upper left and a 14.9-inch central control touch screen on the right half. The double screen is not only larger in overall area, but also slightly tilted towards the driver according to the ergonomic principle. This driver-oriented design concept is also deeply recognized by the author. The bottom of the screen extends to the central control position, and the physical gear handle and a large number of physical touch buttons are reserved, so that the interaction in actual driving is more in line with the driving habit of oil trucks, and the interaction risk of the whole vehicle after a single screen failure is also reduced.

　　In terms of seats, the M50 seat is wrapped in all-black material, and the added blue stitching design makes the interior space full of movement. At the same time, the M sports seat uses a barrel-shaped deep concave shape, which can provide good side support for drivers and passengers. The seat also provides functions such as electric adjustment, seat heating and ventilation, which allows drivers to have a more focused driving experience while driving. Generally speaking, The interior is assembled with the interior of BMW M family, such as M-sports multifunctional leather steering wheel and M-sports seat, all of which increase the exclusive and unique sense of sports luxury of M50. In the whole vehicle space, the author’s height is 187 and his weight is 170 kg, and he is used to sitting in the back. Therefore, in the rear performance of M50, the original standard axle size plus the sliding roof will make the rear space feel depressed and the comfort performance is average.

　　The M50 is equipped with BMW’s fifth-generation eDrive electric drive system. The front and rear double motors of the vehicle are designed, which can provide the maximum output power of 400 kW, the peak torque is as high as 795 Nm, and the acceleration of 100 kilometers takes only 3.9 seconds. Under the CLTC standard, the maximum cruising range of the vehicle can reach 560 kilometers. As for the chassis, the M50 adopts the structure of front double-ball-joint spring shock-absorbing strut and rear five-bar linkage, and the original 4-series foundation is added with a large-capacity battery. The whole feeling is like lying on the ground, with a strong sense of heaviness. Moreover, the suspension supports soft and hard adjustment, so there will be different damping in different modes, and the dynamic feedback of the car body will change accordingly. Advanced chassis technology, intelligent lightweight design and excellent aerodynamic characteristics have shaped extremely exaggerated sports performance.

　　Tianjin zhongxing north international trading co., ltd

　　Address: Room 206, Hall B, International Automobile City, Tianjin Port Bonded Area

　　Sales Tel: 13821856177 Manager Zhang

　　Disclaimer: The above car purchase preferential information is provided by the comprehensive dealers of this website, and the price fluctuates greatly due to market factors, which is only for car purchase reference; The distributor is responsible for its authenticity, accuracy and legality, and this website does not provide any guarantee or assume any legal responsibility.

　 　　

(This article was first published in "Movie Rising Potential", welcome WeChat to search filmmore for attention)　 　　

　 　 　Special feature of 1905 film network　Last weekend, two Hollywood sequels released at the same time, and are simply a pair of he is my brother, both of which have lost their reputation, and the forced implantation of China elements has also been criticized too hard. In "The Rogues 2", Jay Chou did not sing well. On the other hand, the pilot Baby insisted on not hitting the plane with soy sauce, but only opened the honey smile JPG format all the way. You can’t tell the difference between crying and laughing.

In Independence Day 2, the Baby’s smile is charming, but the opening method seems to be JPG.

　 　 In addition to simultaneous appearances in Hollywood blockbusters, another big thing that Jay Chou and Baby have in common is that they both signed a Hollywood brokerage company this year. The difference is that Jay Chou and Hannah Quinlivan joined the Hollywood brokerage "boss" — — CAA。 Baby chose the third UTA.

　 　 In fact, as far away as Gong Li and Chow Yun Fat, as close as Fan Ye and Li Bingbing, China, the "international norm" superstars, have made their debut in many blockbusters and co-productions under the operation of American brokerage companies. Although the vase has passed, the soy sauce has passed, the street has passed, and the thunder has passed, the good Hollywood brokerage company behind them has made great contributions in leading China films and filmmakers to "go global".

　

　 　 Below, Zi Shijun will explain in detail what magic weapons Hollywood brokerage companies have, what they have done in China in the past ten years, and where is the development path of China performing arts brokerage?

[How do Hollywood entertainment brokers play? Here are 5 TIPS]

　 　 In Hollywood, which is famous for its freedom and leisure, there are a group of people who are always in suits and ties, and they are the star agents in Hollywood.

　

　 　 In the Hollywood film industry, where specialization and fine division of labor have reached the extreme, everyone has their own duties, so it is necessary for intermediaries to connect all the links in series. Left-handed art and right-handed money, brokerage companies are indispensable adhesives and lubricants for the operation of Hollywood system. Lucia, UTA’s assistant broker, once said, "In Hollywood, everyone knows that the brokerage company is the core of the entertainment industry."

　

　 　 When it comes to Hollywood brokerage companies, we have to mention the "Big Four", CAA, WME, UTA and ICM. Among them, CAA is a well-deserved brother. It is said that more than 70% of Hollywood popular stars have brokerage contracts with CAA, and the total number of customers is about 5,000. Nearly half of the global box office comes from films directed by CAA directors.

CAA Los Angeles Headquarters, the legendary "Death Star"

　 　 CAA’s headquarters in Los Angeles is nicknamed "Death Star" by the American media, which is taken from and stands for being powerful and invincible. Some people even say that there are only two kinds of people in Hollywood, CAA people and others.

　

　 　 WME’s predecessor WMA is the oldest brokerage company in Hollywood, which was founded in 1898. Hit by CAA in the middle, it was never recovered. However, since the merger with the rising star Endeavor (one of the top five brokerage companies) in 2009, and then the acquisition of IMG in 2013, this old brokerage company has a second spring.

　

　 　 The other two giants, UTA and ICM, although their stalls are not as big as the first two, each has its own advantages. Please see the figure below for the strength comparison of the four Hollywood brokers.

Next page: Tips 1: Not a nanny, but a partner.

　　At the age of 30, Serina Liu became the head of a research team at the Institute of Neuroscience, China Academy of Sciences.

　　It is the dream of young people doing scientific research to set up their own research groups. Serina Liu himself had never thought that this day would come so quickly.

　　In 2018, the news that the world’s first somatic cloned monkey was born in the Institute of Neurology, Chinese Academy of Sciences was released, which was one of the most remarkable developments in the global scientific community that year. Behind this major breakthrough is a young team of "Dr. Tu", and Liu is really one of them.

　　Serina Liu stood out from the crowd thanks to the innovative mechanism and system of Institute of Neurology, Chinese Academy of Sciences. After years of follow-up interviews with the Institute of Neurology of the Chinese Academy of Sciences, the reporter found that the best scientific research soil is accumulating here. After 20 years of exploring the reform of scientific research system, this young research institute is moving towards the ideal of becoming the world’s top scientific research institution. Aiming at the forefront of the world’s science and technology, a lean and efficient research team is marching forward bravely, striving to lead and promote the upgrading of strategic industries with major breakthroughs in basic scientific research, and make contributions to building an innovative country and building a world science and technology power.

　　To grow up "lining", not talent "hat"

　　In 2010, Serina Liu was admitted to the Institute of Neurology of Chinese Academy of Sciences from Shandong Normal University to study for a master’s degree, and joined the macaque platform hosted by her tutor Sun Qiang. In 2016, Dr. Serina Liu graduated and published a research paper on genetically modified monkeys with autism in the top international academic magazine Nature. With his academic achievements during his doctoral period, there is no problem in applying for top foreign laboratories. Serina Liu finally decided to stay and continue his postdoctoral research in the institute.

　　Go to a good foreign laboratory as a postdoctoral researcher, and after publishing one or two good articles, apply to return to China to be a "thousand young people" — — This is the ideal growth track for most doctors in the field of life sciences after graduation. Moreover, with the "hat" of talents, the support of research funds, preferential policies for settling down and so on can follow. However, if you choose to go abroad, most of you can’t continue the project of "making cloned monkeys", and you can only do "short, flat and fast" projects in other directions.

　　The purpose of Serina Liu’s stay is to continue to work on making monkey models of brain diseases. He knows that this is the breakthrough direction of the key layout of the Institute of Neurology of the Chinese Academy of Sciences, and he is eager to join in it. One of the main reasons why most brain diseases can’t be effectively treated is that the current mouse model for developing drugs is far from that of humans, and most of the drugs developed are ineffective or have side effects when tested in humans. The production of disease model monkeys will bring unprecedented bright prospects for the mechanism research, intervention, diagnosis and treatment of brain diseases.

　　Muming Poo, an academician of the Chinese Academy of Sciences and director of the Institute of Neurology, also convinced Serina Liu that only by breaking through the somatic cell cloning technology of nonhuman primates can we truly solve a series of shortcomings faced by macaques as experimental animals, establish a competitive advantage in brain science research in China and become an international leader.

　　"The domestic scientific research conditions are different, and the state pays more attention to personnel training. It is an inevitable trend to make more and more world-leading achievements in China." Serina Liu said, "In my opinion, no place can provide me with better opportunities and support than the nerve center."

　　"For a young scientific research talent who gives up studying abroad and is willing to stay at home to challenge major scientific problems, if the challenge fails, can we correctly evaluate his ability and let him still have a good development prospect?" When Sun Qiang led the team led by Serina Liu to experience numerous failures and achieved the first major breakthrough in the world’s somatic cloning of monkeys, Muming Poo raised a question worth pondering.

　　In July 2018, more than eight months after the birth of the cloned monkey, Serina Liu left the station early after only one year of postdoctoral work in the Institute of Neurology, Chinese Academy of Sciences, and was officially hired as a researcher and became a research team leader of the Institute of Neurology.

　　In the past year, Serina Liu has obtained the same research start-up funds and operation funds as other researchers in the institute. His laboratory is 130 square meters, equipped with five employees, and recruits one or two students every year. "This is enough for a research group that has just started." Serina Liu said that he intends to complete the optimization and efficiency improvement of somatic cloning monkey technology in three to five years, and at the same time, open some interesting topics step by step, such as the neurobiological mechanism of puberty initiation in primates.

　　Serina Liu’s growth trajectory is just one of the cases in which the nervous system does not take the usual path and innovates the system and mechanism.

　　Speak by skill, not by title.

　　"The research team leader recruited by the Institute of Neurology only looks at whether there is a good job, not whether there is experience in studying abroad." When Serina Liu hesitated to go abroad, Muming Poo’s words reassured him.

　　This is not an exception, but a performance-centered talent use and evaluation system that the Institute of Neurology has been insisting on for many years.

　　In 1998, the CPC Central Committee and the State Council made a major decision to build a national innovation system, and decided that the Chinese Academy of Sciences would launch a pilot project of knowledge innovation. As one of the important strategic arrangements of the pilot project, Chinese Academy of Sciences established the Institute of Neuroscience in November 1999, with Muming Poo as its director. At that time, the situation could be called "being ordered at a critical moment", and Muming Poo became the first foreign director of the Chinese Academy of Sciences.

　　"Only by establishing a brand-new institute of modern scientific research system and using a new system and mechanism can we attract talents." At the beginning of its establishment, Muming Poo made up his mind to innovate the operation and management of scientific research institutes and vigorously reform the traditional scientific research evaluation and incentive system. His goal is to establish a top scientific research institution which is recognized by international peers and whose operation mode can be replicated and popularized in China.

　　Since 2003, the Institute of Neurology has taken the lead in introducing an international scientific research evaluation system among national scientific research institutes. Here, heroes don’t ask the source, talents don’t have the distinction of "foreign soil", and researchers should speak by skill, not by title. Even well-known experts should abide by the strict assessment requirements of the institute, and even without a diploma, they can be hired as deputy senior professional and technical posts. All work is to create a good ecological environment for scientific and technological innovation.

　　When receiving the olive branch from the nerve, Sun Qiang was still a little-known university lecturer. He graduated from Inner Mongolia University for Nationalities with no overseas study experience. At the age of 36, he had just been awarded the deputy senior title and experienced the failure of developing transgenic monkeys. He once considered whether to give up the research on nonhuman primates. At an academic conference, I learned about Sun Qiang’s practical foundation and technical level for many years. Muming Poo introduced him as a full-time senior engineer and entrusted him with the task of building a research platform for nonhuman primates.

　　To work here, Sun Qiang only made one condition to Muming Poo: to bring two veterinarians with only junior college education. Although their education is not high, they are a very important part of the scientific research team and need spirituality and concentration to achieve the ultimate.

　　At the beginning of 2018, the world’s first cloned monkey "Zhong Zhong" and "Hua Hua" cultivated by Sun Qiang’s team appeared in Cell magazine. This achievement, independently completed by scientists in China, is known as "a milestone breakthrough in the field of biotechnology in the world". The birth of the cloned monkey also proves that China has reached a stage from gradual and incremental innovation to a major breakthrough.

　　Are "Dr. Tu" and "Dr. Tu" not as good as those who have drunk "foreign ink"? Obviously not. Major breakthroughs, such as synthetic insulin, have been made by local scientists in China, most of whom are young scientists. In Muming Poo’s eyes, young people are the most innovative when they are 25 to 35 years old, but many excellent students go abroad as postdoctoral fellows, and devote the time that they can do experiments wholeheartedly to foreign laboratories in order to become "foreign talents" and get the talent "hat" smoothly.

　　"It seems that if you don’t go abroad, you can’t find a good job, and you don’t pay enough attention to the local talents you cultivate. This kind of employment orientation must be changed." Muming Poo regrets, "truly successful people don’t necessarily have to go abroad. It is very important to keep excellent doctoral and postdoctoral students in domestic first-class scientific research units and give them opportunities for innovation. There must be various mechanisms to encourage such talents. "

　　This is what the nerve has been trying to do. Under the leadership of Muming Poo, the Institute of Neurology has continuously deepened the reform of mechanism and system, and made in-depth and extensive explorations and attempts in the innovation of system and mechanism such as postgraduate training, team research to promote cross-integration, selection and promotion, and evaluation.

　　Yan Wang, secretary of the Party Committee of the Institute of Neurology, summed up the basic principles of talent work in the Institute of Neurology — — Provide a relatively stable scientific research environment, so that scientists can focus on research work; Carry out strict international assessment and implement a benign flow mechanism; Guide researchers to resist pressure and temptation, so that young scientists can work in a down-to-earth manner.

　　With these three rules, the breakthrough is ahead, and all it takes is time. Of course, it is very important to delve into major issues.

　　Stick to "big problems" instead of "short-term" topics.

　　"Big problem" is a key word deeply rooted in the culture of the Institute of Neurology.

　　It is precisely because of aiming at major scientific problems that the non-human primate research platform is built and perfected. In fact, since 2002, many research institutions in the world have started the research on somatic cell cloning of nonhuman primates. In 2010, Mitalipov, a scientist from Oregon Primate Research Center, led a team to successfully transplant cloned monkey embryos, but unfortunately, the success failed, and the embryos ended in abortion after 81 days of development.

　　However, due to the high investment cost and long output cycle of primate research, at first, many researchers who took mice as experimental objects inside and outside the Institute of Neurology were not optimistic about the investment in somatic cloned monkeys. In 2009, Muming Poo made a public opinion, and used the director’s fund layout to build a non-human primate research platform. That year, the Chinese Academy of Sciences tried out the only stable support policy for the whole hospital system, including the director’s fund. Since 2012, the non-human primate research platform project has been supported by Chinese Academy of Sciences. The background is that the Chinese Academy of Sciences, as a national strategic scientific and technological force, launched the strategic pilot science and technology project (Class B) "Study on Brain Function Linkage Map" in this year. This special project is one of the first five Class B pilot projects initiated by the Chinese Academy of Sciences, which is earlier than the start time of related "brain projects" in the United States, Japan and the European Union.

　　In 2014, the Chinese Academy of Sciences launched the "First Action" plan, which outlined the reform of the classification of research institutes and comprehensively promoted the reform of institutional mechanisms. In the same year, based on the Institute of Neurology, the Center for Excellence and Innovation in Brain Science of Chinese Academy of Sciences was established, becoming one of the first four centers for Excellence and innovation established by Chinese Academy of Sciences.

　　In 2015, during the planning of "China Brain Project", scientists in China put forward a "one body and two wings" architecture, that is, the neural principle of brain cognition as the "main body" and the new means of diagnosis and treatment of brain diseases and the new brain-like intelligent technology as the "two wings". The Chinese Academy of Sciences responded quickly and planned the coordinated development of brain science and brain-like research. The Center for Excellence and Innovation in Brain Science and Intelligent Technology, jointly planned by Institute of Neurology and Institute of Automation, was formally established in this year.

　　Major changes have spawned major outputs. Perhaps coincidentally, on November 27th, 2017, the 18th anniversary of the establishment of the Institute of Neurology, the somatic cloned monkey "Zhongzhong" was born. In Muming Poo’s view: "The reason for our success is that we saw that this problem can be solved and stuck to it, while most foreign laboratories gave up. Our success is due to the cohesion of a group of cutting-edge talents. "

　　"If you want to make a breakthrough scientific discovery, you must do important problems. I hope that the teachers and students of the Institute of Neurology have the confidence to do the best work, have the confidence and courage to do important problems, and eventually make breakthrough scientific discoveries. " Muming Poo is convinced. The "baton" of evaluation is also guiding everyone to explore innovative major scientific issues in line with the direction of national strategic development, rather than simply doing the topic of "fast, safe and easy to publish articles".

　　At the end of November every year, it is the "big gathering" of the Institute of Neurology. After the establishment of the Center for Excellence and Innovation in Brain Science and Intelligent Technology, this tradition continued and became the "big gathering" of the whole center, and the performance evaluation of the year was carried out at the same time as academic exchanges. The evaluation results are the basis for researchers to apply for annual research funds and adjust performance allowances, and directly affect their funding and promotion opportunities.

　　The results of performance evaluation are divided into three grades: A, B and C. Members who have been rated as C for two consecutive years will be required to make rectification, and the annual performance allowance will be stopped during the rectification period; Members who have been rated as C for three consecutive years will be asked to withdraw; Members who have been rated as A for two consecutive years will be given priority in promotion assessment.

　　Yan Wang remembers that when it was first implemented, the impact was great. Some researchers can’t figure out: why did they get a C in the evaluation because they have sent so many papers with high impact factors? Because the evaluation criteria are different, the "paper-only" evaluation system has been broken since the end of 2015, focusing on the contribution to the team’s key projects, excluding the results unrelated to the team’s projects; There are significant innovative achievements in the key areas of the center layout; The investment in interdisciplinary communication includes multi-unit "squatting" teaching and research, and guiding dual-tutor graduate students.

　　What are good results and big results? What kind of achievement is a major breakthrough? "It is a major breakthrough to open up new scientific research fields and achieve milestones in the original scientific research fields. Looking around the world, the world’s top scientific research institutions have such achievements. Every scientific research field has well-known major unsolved problems, and it is the real leader in this field to continuously make major breakthroughs in one field. " Muming Poo said.

　　It is necessary to "explore freely" and "tackle key problems by team"

　　"It has been 5 years since I returned to China. Let’s see when I can get the first clinical approval." On July 8, Yang Hui, a researcher at the Institute of Neurology, wrote this sentence in a circle of friends, with a smiling expression of high morale.

　　In 2014, 29-year-old Yang Hui became the youngest researcher in the Institute of Neurology, and served as the leader of the primate disease model research group and doctoral supervisor. "90% of rare diseases are incurable. Can we do something with gene editing?" Yang Hui said that rare diseases are actually not rare. There are more than 7,000 rare diseases found in the world, with more than 300 million patients, more than cancer patients. The goal of him and his team is to develop more efficient and safer gene editing tools and build a research and development platform for treating rare diseases. "The first gene drug in China will not be too far away".

　　In the first half of this year, Yang Hui’s research group had a bumper harvest, and published two papers in Science and Nature. It was the first time in the world to confirm the off-target effect of single-base gene editing, and then further repaired the off-target "loophole" and established a new generation of single-base gene editing tools. The young researcher said frankly: "I’m still very uneasy, and I’m most worried about disappointing the students’ efforts day and night. Teacher Pu is still helping us to change articles over and over again during the Spring Festival holiday. Thank you for your efforts and hope that the results will benefit China patients as soon as possible. "

　　The birth of somatic cloned monkeys undoubtedly brought Yang Hui closer to her dream. Starting from 2018, a monthly seminar on cloned monkeys will be held. In addition to the main personnel of the primate platform, many research groups of the Institute of Neurology will participate, expecting to bear more innovative fruits in deep cross-integration. Sun Qiang said that on the basis of successfully constructing the world’s first batch of somaclonal monkeys with dysrhythmia, more efforts are being organized, and the efforts of the Institute, the Center of Excellence and even the whole country are gathered to develop a variety of disease model monkeys and tool monkeys developed by somaclonal monkey technology as soon as possible. "Many research groups in the Institute have cooperated with us."

　　In Muming Poo’s view, at present, breakthroughs in most fields require cooperative research, and establishing a concise and efficient research team is the key to a major breakthrough. "The biggest challenge in the biological science community at present is to establish an effective research team." The molecular mechanism and variety design of synthetic bovine insulin with full activity, high yield and high quality rice are not the results of individual combat. To make breakthrough work on major issues requires the team spirit of sincere cooperation, hard work and perseverance of each member, and puts the task and goal of team research above personal gains and losses.

　　This is also the first-class scientific research culture that Muming Poo has always advocated, and the first-class scientific research institutions should have. "Looking for the development direction of the frontier of science must be free to explore. However, with the development of science and technology, it is difficult to make a real breakthrough only by individual’s free exploration. Therefore, it is an inevitable trend for young and middle-aged scientists to abandon the limitations of fame and fortune, cooperate with each other and jointly answer important scientific questions. "

　　At the beginning of its establishment, the Institute of Neurology insisted on joint team research as the core way to solve major problems, and actively explored the establishment of scientific research systems and mechanisms that take into account collective goals and personal interests, demand orientation and free exploration. Here, most of the personal interests of scientific researchers are respected, most of their personal expertise is found, and valuable and distinctive frontier research fields are basically covered.

　　Muming Poo has a profound understanding of the training methods of Chinese and Western scientists, and he hopes to promote the establishment of a new scientific culture in the nerve center and cultivate intellectuals who inherit China’s traditional values. In his view, Chinese researchers should have the spirit of selflessness, and more importantly, they should have the feeling of "worrying about the world first, and enjoying the world later" of China traditional intellectuals, so as to serve the country with scientific and technological achievements.

　　"Please don’t buy things you don’t need in the near future. I am very seriously opposed to the idea of spending all the unspent funds before the end of the year. If we can’t use up the money, it means that we don’t need it. We must return it to the Chinese Academy of Sciences or other sources. This is the correct attitude of a scientist with social responsibility. " Muming Poo once sent an email to the research group leader in the institute.

　　In his view, it is a basic social conscience that researchers should use research funds cautiously. The level of scientists is expressed by ideas and innovation, not by the latest models of instruments they have. The wind of "grabbing" resources once appeared in academic circles is a waste to society. The practice of the Institute of Neurology also proves this point. The rapid development depends not on the input of resources, but on the ideal of building a world-class scientific research institution and persisting in promoting the reform of the system and mechanism.

　　At the beginning of his tenure as director of the Institute of Neurology, Muming Poo once put down his grandiloquence: "I have never been so confident in successfully establishing a world-class research institute on the land of China. This will be a research institute that will be recorded in the history of science in China. As the first director of the Institute of Neurology, I am determined to do my best to turn the Institute of Neurology into a fertile soil where the seeds of scientific invention will sprout, take root and blossom. "

　　This year, 71-year-old Muming Poo will soon witness the 20th year of this research institute, which has devoted countless efforts to it, and complete another major turn. In the near future, it will continue to complete its mission and responsibility under the name of "Center for Excellence in Innovation of Brain Science and Intelligent Technology of Chinese Academy of Sciences".

　　Innovation, innovation, and innovation.

　　Fusion, fusion, re-fusion.

　　This is the result of the times and the general trend. At present, the research of brain science and intelligent technology is facing unprecedented development opportunities. After 20 years of intensive cultivation, a research team led by outstanding scientists and with outstanding young scientists as the main body has become increasingly mature and has become a main force in the research of brain science and intelligent technology in China. After 20 years of reform and innovation, the rivers crossed, the bridges crossed and the roads traversed have been integrated into the great process of China’s scientific and technological innovation to overcome difficulties and become a cornerstone to consolidate the innovation-driven development strategy. (Reporter Yan Weiqi)

With the popularity of electric vehicles, electric car charger has become an indispensable accessory for every electric vehicle user. However, there are many kinds of chargers in the market. How to choose a charger that suits you? The following will be popular science for everyone from several key aspects.

* * First, understand the battery type of electric vehicles * *

First of all, we need to know what kind of batteries our electric cars use, such as lead-acid batteries and lithium batteries. Different types of batteries have different requirements for chargers, so the choice of chargers must match the battery type.

* * Second, pay attention to the power and current of the charger * *

The power and current of the charger directly affect the charging speed and battery life. The higher the power, the faster the charging speed, but it may also cause damage to the battery. Therefore, when choosing a charger, we should choose a charger with moderate power and stable current according to the battery capacity and our own needs.

* * Third, pay attention to the safety performance of the charger * *

Safety performance is an important factor that cannot be ignored when choosing a charger. A high-quality charger should have multiple protection functions such as overcharge, overdischarge, overheating and short circuit to ensure the safety during charging. In addition, the charger with national certification mark should be selected to ensure product quality.

* * Fourth, consider the portability and ease of use of the charger * *

For users who often need to go out to charge, the portability and ease of use of the charger are also factors to be considered. Lightweight and compact chargers are easy to carry, while simple chargers can lower the use threshold.

* * 5. Understand the brand and reputation of the charger * *

Brand and word of mouth are important references when choosing a charger. Well-known brands usually have more advanced technology and stricter quality control, while good reputation means that products have been recognized by users in practical use.

To sum up, choosing a electric car charger that suits you needs to be considered from many aspects. I hope the above popular science content can help you to choose electric car charger better.

Execution linkage, smashing inter-provincial fake wine criminal gangs

—— On-the-spot report on the case of investigating and handling the production and sale of counterfeit "Niulanshan" registered trademark liquor in Haining, Zhejiang Province

China Quality News Network News "The manufacture and sale of fake wine not only infringes on the trademark rights of merchants, but also brings food safety risks, which is extremely harmful to society and must not be tolerated!" After half a year’s careful investigation, Haining Public Security Bureau of Zhejiang Province and Haining Market Supervision Bureau jointly acted, and recently successfully destroyed an inter-provincial criminal gang that produced and sold counterfeit "Niulanshan" registered trademark liquor, and arrested 22 suspects, involving a total amount of 10,000 yuan in Wu Bai.

Winery counterfeiting provides clues

At the beginning of 2021, Xinyoutai Liquor Industry, a distributor of Niulanshan Winery in Haining, contacted the Comprehensive Administrative Law Enforcement Team of Haining Municipal Market Supervision Bureau (hereinafter referred to as the Law Enforcement Team), saying that there may be counterfeit "Niulanshan" liquor in Haining, but the specific situation is unknown, and there is neither direct evidence nor directional clues. After receiving the clue provided by the dealer, the comprehensive law enforcement team decided, through research and analysis, to keep continuous attention on the clue, strengthen daily supervision and inspection, and gradually grasp the first-hand situation through targeted troubleshooting.

Suspected fake wine "appears" in the construction site canteen

On March 16th, law enforcement officers of Huangwan Market Supervision Institute of Haining Municipal Market Supervision Bureau inspected the canteen of a construction site in Jianshan New District and found that the canteen was suspected of operating without a license, so they conducted on-site evidence collection according to law. In the process of obtaining evidence, law enforcement officers, as usual,the sameInspected, but paid special attention to the sales of "Niulanshan" liquor. The "Niulanshan" liquor in the canteen is placed on a small shelf far from the door. After inspection, law enforcement officers felt that there was something wrong: there was no difference between the packaging boxes and bottle labels of these wines and genuine Niulanshan liquor, and the outer packaging was printed with "Niulanshan aged liquor" and marked with "net alcohol content of 42% vol: 500ml, production date: 201910202, place of origin: Langfang City, Hebei Province (2), entrusted party: Chengdu production base of Niulanshan Distillery of Beijing Shunxin Agricultural Co., Ltd.". However, law enforcement officers felt that the wine was slightly different from the common Niulanshan. Combined with previous clues, law enforcement officers suspected that the wine was not genuine. After on-site inquiry, the parties prevaricated and could not tell the source. Law enforcement officers took measures to register and preserve 137 bottles of liquor in advance.

A self-proclaimed "Niulanshan" liquor agent surfaced.

Law enforcement officers contacted Niulanshan Distillery of Beijing Shunxin Agricultural Co., Ltd., the trademark registrant of Niulanshan, through Xinyoutai Liquor Industry. After identification, the above-mentioned liquor was not produced by the company, but was indeed a counterfeit product. Law enforcement officers seized 137 bottles of "fake wine" according to law.

After obtaining the appraisal result of the manufacturer, the law enforcement officers further inquired about the operator of the canteen. "When you purchase goods, did you check the agent qualification of the other party and check the business license and business license of the other party?" "No." At this time, the canteen operator truthfully confessed: "In January, an agent who claimed to be’ Niulanshan’ liquor came to our store to sell it and said that it could be delivered to the door. It was a little cheaper than others, and we believed that he had entered his wine." In addition, during the inspection, law enforcement officers found that other nearby snack bars for migrant workers were also supplied by this person. According to the judgment of the confession law enforcement officers, the dealers of counterfeit liquor aimed at specific sales targets and made targeted door-to-door sales. The counterfeit liquor flowing into the market was definitely not limited to the number that had been detained, and immediately decided to inform the law enforcement team of the clues of the case. After receiving the notification, the law enforcement team immediately organized law enforcement personnel to conduct a comprehensive network investigation in the incident area. Through the network-pulling investigation, they gradually grasped the micro-signal of the dealer and the preliminary illegal clues.

Cross-provincial network arrest, criminal gangs caught the gang.

The law enforcement team conducted the preliminary investigation through the micro-signal of the self-proclaimed "Niulanshan" dealer. After the preliminary investigation, the relevant case materials were officially handed over to the public security department. The Haining Public Security Bureau set up a task force, and through the dealers of the fake wine gang in Haining, they tracked down their dealers in Jiaxing, Zheng Motao, Yan Momin, Zhou Moufei, Zheng Mouhui, a dealer in Zhejiang Province, Tang Mobin, a dealer in other counties and cities in Jiaxing, a logistics service department of Xu Shui, a manufacturer of a wine company in Hebei and a wine company in Baoding. On December 2, 2020, Haining Public Security Bureau dispatched more than 90 law enforcement officers to arrest members of locked criminal gangs. On the same day, 21 suspects were arrested.

After investigation, the cost price of a bottle of counterfeit liquor is about 3 yuan. After a multi-layer selling network, it finally flows into the canteen, and the price is more than 10 yuan per bottle. Haining City Market Supervision Bureau attached great importance to the clues of the case, quickly pulled the net for investigation, promptly handed it over to the public security, and fully cooperated with the investigation. After half a year, the case of producing and selling counterfeit "Niulanshan" registered trademark liquor was finally solved. Niulanshan Winery of Beijing Shunxin Agricultural Co., Ltd., the owner of Niulanshan brand, would like to thank the Municipal Public Security Bureau and the relevant case-handling agencies of the Municipal Market Supervision Bureau for presenting pennants respectively. (Source: Haining Market Supervision)

Academic Scholar Li Weiwen: The Original Journal of Li Weiwen’s Architectural History from the Beginning to the End of the Reconstruction Plan of Beijing Ancestral Temple in Jiajing Dynasty of Ming Dynasty

In the tenth year of Jiajing (1531), Emperor Shizong of the Ming Dynasty initiated a reform of the ancestral temple system in Beijing, aiming at transforming the pattern of different rooms in the same room into the pattern of different halls in the capital. As an engineering decision-maker, Ming Shizong personally formulated the planning principles, and his assistant team submitted several rounds of design schemes and accepted the examination and approval of the emperor, which finally deepened the design scheme and practice of Nine Temples, which was recorded in history. This process was recorded in detail by Xia Yan, a courtier, which not only helps to deepen the understanding of the evolution of the ancestral temple in Beijing, but also helps to understand the operation mode of ancient architectural projects in China and the role of architects.

Ming jiajing dynasty Beijing ancestral temple

The whole process of reconstruction planning scheme generation

Li weiwen

After Zhu Houzong (hereinafter referred to as Emperor Shizong of Ming Dynasty) ascended the pole, a series of national sacrificial rites reforms were launched, and the altar and temple facilities in Beijing were completely transformed. After Zuo Shunmen’s incident, the results of the big ceremony for his biological father (Xing Xian Di) God gradually stabilized, but Ming Shizong was always unwilling that the ancestral temple (Figure 1) failed to make a better temple system. The reform of the temple system in the later stage of Shizong in Ming Dynasty can be regarded as the continuation of the great ceremony in depth.

Figure 1 The plane state of Beijing ancestral temple in 1942.

The controversy over the ritual system is not the only obstacle for Ming Shizong to practice his personal temple system. On the specific renovation planning of the ancestral temple complex, Ming Shizong also felt a considerable obstacle, that is, as he said, "it is difficult to make the temple system more correct." In order to change the temple system, Ming Shizong launched a far-reaching action. The final result of this action was the completion of the Jiumiao complex at the end of the 15th year of Jiajing (1536) and the implementation of the new memorial ceremony. Until the 20th year of Jiajing (1541), the pattern of Jiumiao was destroyed by fire, which constituted a short and compact chapter in the history of Beijing ancestral temple (Figure 2). Yan Kai has basically combed this process in his thesis "Research on the Architecture of Beijing Ancestral Temple". However, the transformation of the ancestral temple from the original regulation of different rooms in the same room to the pattern of different halls in the same palace did not happen overnight, but it went through repeated planning and many scheme adjustments for quite a period of time. The gradual deepening of this series of architectural schemes was recorded in detail in the script of the participants such as Xia Yan, the assistant minister. Through these historical records, this paper attempts to restore the formation process of the planning and design scheme of the nine temples in Jiajing, Ming Dynasty, and to get a glimpse of the decision-making operation in the planning and design of national architecture in Ming Dynasty.

Fig. 2 Restoration performance diagram of Jiajing ancestral temple reconstruction design

Determination of planning conditions and Zhao Shanming’s scheme

As early as a few years before Emperor Shizong of the Ming Dynasty really started to promote the reconstruction of the ancestral temple, he had revealed his plan to transform the ancestral temple into a palace hall on many occasions. One of the earliest times was a duet recorded by Li Shi in his "South City Calling Couples". Li Shi didn’t record the specific time of the dialogue, but according to Xia Yan’s record of the same performance in his book "Taking into account the ancient and modern temple system, begging for clarity and breaking the sparse", it can be known that it happened in November of Jiajing Decade (1531). In this dialogue, Emperor Shizong of Ming Dynasty raised the concern that "the ceremony of worshipping a hundred gods in the suburbs is correct, but the ceremony of the ancestral temple is not perfect", and cited the story of Ming Taizu’s establishment of the four-parent temple, advocating the transformation of the ancestral temple into the form of a palace. However, the attitude of several ministers is very cautious. On behalf of several ministers, Li Shi first expressed the attitude that "the ceremony of nine temples is impossible". This attitude is not only considered from the perspective of etiquette, but also involves the time and physical strength required for the emperor to worship the nine temples. However, Emperor Shizong of Ming Dynasty did not elaborate or defend the connotation of the ritual system of the Nine Temples, but directly made a statement on his idea of transforming the ancestral temple: "I want to stay in the main hall. It is said: it is good not to move the hall. When I was a minister, I said, Don’t you move the bedroom? Above, they said, "None of the three halls will move.".

Emperor Shizong of the Ming Dynasty explained the basic planning conditions for the reconstruction of the ancestral temple to his closest officials, which actually explained the overall scale of the project and the disturbance degree to the main building of the existing ancestral temple. By determining the first principle that the three halls of the ancestral temple should not be demolished and rebuilt, Emperor Shizong of Ming Dynasty hoped to dispel his officials’ doubts about the nature of the project and gain their support. In the dialogue, Emperor Shizong of Ming Dynasty denied Xia Yan’s solution of temporary structures, and determined the permanent architectural nature of the project. By promising the planning principle of "don’t have to fit the ancient" and "don’t move the main hall, only use two temples ….. only have its meaning", the upper limit of the total project is explained, which dispels the exaggerated imagination and worry of the liegeman about the concept of "all palaces and separate halls". As a result, Xia Yan and others’ attitudes were obviously eased. "At first, I saw the sacred worry … the three halls did not move, and things were easy." A design team began to form.

Nevertheless, the Dugong Biedian is still a vague concept of etiquette, leaving a lot of room for specific architectural forms. The so-called Nine Temples can be nine groups of buildings with similar scale (such as the Nine Temples of Wangmang) or a complex with clear priorities, and the ritual connotations of these possibilities are different. After this performance, Xia Yan put forward two obstacles for the ministers to make the plan of the Nine Temples. First, the ancient ceremony required Zhao Muqun Temple to be in the south of the ancestral temple, but the land south of the ancestral temple was not plentiful: "If the temple of three Zhao and three Mu was in front of the ancestral temple according to the ancient system, it would be very far from the south of the imperial palace to the Chengtianmen wall. Even if you do your best to build a group of temples, you will be afraid of the situation. " Secondly, the scale of Zhaomu temples in ancient rituals is imitated as ancestral temples or only slightly increased or decreased. If such a design is adopted, the shortage of land will be aggravated. However, if the scale is reduced to the extent that the existing land can be accommodated, it is not appropriate in the ritual system: "The ancients had seven temples and nine temples, and the system was the same. The structure of the ancestral temple is extremely grand and strong, and the temples in the group are humble, so I am afraid it is not called the residence of the nine temples before my death. " The solution of these two contradictions runs through the whole project planning.

In the 11th year of Jiajing (1532), Zhao Shanming, an experienced officer of the Chinese army, introduced the reconstruction scheme of the ancestral temple (numbered scheme I in this article), and Emperor Shizong of the Ming Dynasty ordered the auxiliary ministers to evaluate the scheme. On March 12th of that year, Xia Yan refuted Zhao Shanming’s visit to the temple in his book Refuting the Experience of Zhao Shanming’s Temple, directly questioning Zhao Shanming’s "lack of etiquette". Surveying and mapping the ancestral temple without permission, "measuring refers to painting" and "things are good at drawing". However, since Emperor Shizong of Ming Dynasty ordered Xia Yan and others to evaluate Zhao Shanming’s proposal, it shows that he is interested in the proposal and at least agrees with some of its ideas. Therefore, Zhao Shanming’s plan can be regarded as the first conceptual plan for the transformation of the ancestral temple.

Zhao Shanming first emphasized in his recitation that his plan followed the planning principle defined by Emperor Shizong of Ming Dynasty, and that "the ancestral temple, the second bedroom temple and the Golden Gate were all untouched". The main points of its plan are as follows:

Expand the whole land of the ancestral temple and push out the existing ancestral temple wall to the four sides. The east wall of the expanded ancestral temple is close to the west wall of the World Temple, leaving five feet between them, and the existing river channel between the ancestral temple and the World Temple is changed into a culvert; The north wall is in line with the north wall of the World Temple; The western wall reaches the corridor along the front line of the end gate and the noon gate, leaving five feet behind; The south wall reaches the imperial city wall on the east side of Chengtianmen, leaving five feet with it. The five-foot gap left in the above three directions will form a "U"-shaped carriageway. The expanded land for the ancestral temple completely occupies the area east of Liuke Gallery, south of Tongzi River and west of the World Temple, which will basically occupy the existing pine and Berlin.

Due to the external expansion of the walls of the ancestral temple, the main courtyard of the ancestral temple will be independent from the center of the land. Taizong Temple and Sanzhao Temple are arranged on its east side, and Sanmu Temple is arranged on its west side, with a total of seven groups of buildings. Zhao Shanming demarcated each group of construction land as 30 feet deep and 28 feet wide, and reserved tunnels in between. According to its own calculation, except for Taizong Temple, Sanzhao and Sanmu are arranged from the new south wall of Taizong Temple to the north, with a total depth of 95.4 zhangs, and its land use is the same as the southern edge of the pedestal of Taizong Temple. The World Temple maintains the status quo (Figure 3).

Fig. 3 The idealization of Scheme I refuted in Xia Yan’s recitation on March 12th, 11th year of Jiajing (1532) in Gui Zhou Recital.

Left: there are both ancestral temples; Right: Planning the ancestral temple

It should be noted that Zhao Shanming’s reconnaissance and design work are all his personal behaviors, and his grasp of the overall scale of the ancestral temple is quite biased. If, according to the real scale of the ancestral temple area, the wall branch is expanded as planned, the central building complex of the ancestral temple will not be in the middle of the area, but will be slightly west. It is also difficult to realize the scale of the group temples designed by Zhao Shanming. Once arranged, it will completely fill the space on both sides of the ancestral temple, especially on the narrow west side. If a group of temples are arranged with a width of 28 feet, it will not meet the 5-foot-wide imperial road in the temple street gate reserved in Zhao Shanming’s plan. Therefore, the performance in Figure 3 of this paper has made some adjustments to the scale of the group temples, and the size of the group temples in the figure is slightly smaller than the data given by Zhao Shanming to reflect the original intention of the scheme.

In addition, Zhao Shanming’s plan also involves a number of environmental adjustments, including using the existing rocks in the pine forest of Taimiao, "after moving to the World Temple, fill the river and fill it up, and grow more pines and cypresses to protect the Xuanwu side"; Plant more flowers and trees in front of the ancestral temple. With regard to the material raising for the project implementation, the scheme even puts forward the idea of designing the large wooden structure in advance and sending it to the southern provinces to deliver the large wooden components to Beijing after production, which is quite imaginative. However, all these proposals were refuted by Xia Yan. Xia Yan only affirmed Zhao Shanming’s proposal that Taizong and Shimin temples should not enter Zhaomu and remain immortal out of his observation of the original intention of Ming Shizong’s ritual painting.

Looking at Zhao Shanming’s plan, its overall idea basically meets the planning conditions proposed by Ming Shizong, but its planned area for Zhaomu Temple is too large, and the existing trees are cut down too much, which does not reflect the original intention of Ming Shizong to accommodate new buildings only in two spaces. In addition, its scheme only affirmed the immovable status of the World Temple from the ritual system, but did not give an architectural solution, which could not satisfy the selfishness that Ming Shizong did not point out, which was an important weakness of the scheme.

The deepening of Zhao Shanming’s plan and the plan of Jiumiao Dugong

After Xia Yan’s criticism, Zhao Shanming’s plan was also rejected by Ming Shizong. But soon, on the second day of April in the 11th year of Jiajing (1532), Xia Yan went to the book "Rules and Regulations on Building a Ancestral Temple in Jincheng" and introduced two improvement schemes with several courtiers and internal supervisors, which showed that Zhao Shanming’s proposal really extended the discussion on the temple system for some time.

Xia Yan mentioned in this lecture that after the personnel who participated in the engineering design made a reconnaissance of the ancestral temple, a plan for expanding the outer wall of the ancestral temple in three directions (scheme II in this paper) was briefly put forward. In fact, this plan is very close to the idea of Zhao Shanming’s plan, that is, expanding the land for the ancestral temple to accommodate the group of temples, but the scale of this expansion is far smaller than that of Zhao Shanming’s plan, and it is still basically controlled outside the two temples of the existing ancestral temple (Figure 4). The biggest adjustment of Zhao Shanming’s scheme in Scheme II is to give up the idea of trying to strictly control the land of Zhaomu Temple in the south of the existing ancestral temple according to ancient rites, thus greatly alleviating the land shortage on the south side of the ancestral temple in Zhao Shanming’s scheme. The scale and arrangement of the group temples were not mentioned in the recital, but we can see that the total depth of each group temple in the east and west still exceeds the existing ancestral temple land, and the purpose of expanding the south wall is to form a new capital palace to match the total depth of the group temples. However, it is not stated in the recitation whether the Taizong Temple, the ancestral hall of Wenzu, is also included in the scope of the capital palace.

Fig. 4 Scheme II mentioned in Xia Yan’s recitation on the second day of April in the 11th year of Jiajing (1532) in Gui Zhou Memorial.

Left: Existing land; Right: Planned land use

It is recorded in the notes that this design has undergone a new adjustment, forming another scheme (scheme ⅲ in this paper), that is, the east-west wall remains completely intact, and only the width of two gaps is used to accommodate the Zhaomu Temple; The south wall is still spreading to the south, but to a lesser extent: "There is no need to spread the east and west walls, but only 14 feet and 4 feet in the wall divided by 20 feet and 9 feet as the royal road, 11 feet and 5 feet as the width of the temple, and 22 feet and 5 feet as the depth of the temple … The temple gate wall only spreads to the south by 80 feet and 8 feet".

In this scheme, each group of Zhaomu temples is arranged vertically, and two royal roads connecting the temples run through from the inside, forming a ∩-shaped passage with the tunnel between the back wall and the back wall of the temple. According to the design of 8.8-foot south extension of the south wall of Taimiao in this plan, Taizong Temple has been clearly incorporated into Dugong at this time: expanding the south wall by 8.8-foot on the basis of the total depth of 81.2-foot of Taimiao will form a Dugong with a depth of 90-foot, and the hatchback can just accommodate four temples adjacent to the north and south with a depth of 22.5-foot (Figure 5). The planning of Jiumiao Dugong was thus formed.

Fig. 5 Scheme III mentioned in Xia Yan’s recitation on the second day of April in the 11th year of Jiajing (1532) in Gui Zhou Memorial.

Left: Existing land; Right: Planned land use

This plan has not involved the architectural design of each temple in detail, but only mentioned that "each temple will only build a main hall with five rooms" and there is no sleeping hall. It shows that the officials who participated in the design at this time have fully understood the instruction of Ming Shizong about the design of group temples, and no longer pursue the perfection of regulation and the far-reaching scale. At this point, the feasible factors in Zhao Shanming’s scheme have been basically extracted, while his exaggerated assumption on the scale of land use has been abandoned. However, for this deepening plan, Emperor Shizong of the Ming Dynasty only approved "Stop", and the reconstruction of the ancestral temple was put on hold for some time. Perhaps this is still due to the controversy over the connotation of the ritual system.

On September 8th, 13th year of Jiajing (1534), Xia Yan and others were ordered to visit the ancestral temple again, and a new round of design began. The origin of this design was the disaster of the ancestral temple in Nanjing, which was interpreted by Xia Yan and others as the auspicious feeling that ancestors expected the new temple system, which made Ming Shizong make up his mind. Xia Yan quoted the architectural design scheme of a group of temples personally put forward by Emperor Shizong of Ming Dynasty in his Regulation of Seven Temples at the Order, that is, "the system does not need to go far from the front and back temples, that is, the front hall has five rooms, the tiger seat is backward, and three rooms are connected to the dormitory from Zhangyu, which is also righteous." The reason why Emperor Shizong of the Ming Dynasty took the lead in guiding the design of the buildings of the ancestral temples when the overall pattern of the renovation was not yet determined was that on the one hand, he insisted that the regulations of the temples still needed to be complete, denying the simple design of each temple with only one main hall, on the other hand, he restricted the occupation scale of the newly-built temples, further reducing the impact on the existing pattern of the ancestral temples.

Fig. 6 Scheme IV mentioned in Xia Yan’s recitation on the eighth day of September in the 13th year of Jiajing (1534) in Gui Zhou Memorial.

Left: Existing land; Right: Planned land use

According to Xia Yan’s recitation, "It was originally planned that the regulations of the temples would reach the south wall of the ancestral temple, then the east and west temple walls would go out before the Jimen Gate of the ancestral temple, and there would be obstacles in the kitchen of the Shenku". It can be seen that there was still an intermediate scheme (scheme IV in this article) between the eleventh year of Jiajing (1532) and this new discussion in the thirteenth year of Jiajing (1534). In this scheme with unknown formulation time, the south wall of Taimiao does not expand to the south, indicating that the total size of the temples has been reduced again. However, the land for Zhaomuqun Temple will still stand out from the south of Jimen Line, "reaching the south wall of Taimiao". The design of the extended hatchback, such as schemes III and IV, will lead to the narrowing of the square between the Jimen Gate and the Liulimen Gate of the Imperial Temple, and at the same time, it is necessary to move the Shenku Shenchu and Jingting (Figure 6). These problems may be the reason why Ming Shizong personally restricted the scale of the main buildings of various temples in September, 13th year of Jiajing (1534). Under the new guidance, the area occupied by the temples in the group can continue to shrink, and the southernmost part "merges with the side door of the ancestral temple gate, and the straight north back wall merges with the ancestral temple temple", and a new scheme of "solemn potential" (scheme V in this paper) can be formed. From then on, all the designs that caused the uneven parts of the land or the need to move the wall were put an end to.

Fig. 7 Plan V mentioned in Xia Yan’s recitation on the eighth day of September in the 13th year of Jiajing (1534) in Gui Zhou Memorial.

Left: Existing land; Right: Planned land use

The plane pattern logic of scheme V is completely the same as that of the later implementation. Compared with the above-mentioned schemes, the difference between them and schemes I, II and III is that the four external walls are not expanded; The difference with Scheme IV is that the inner wall does not move, while the new wall strictly follows the extension line of the existing frame. In the new scheme, the scale of each temple group is equal, the depth is 16.15 feet, and the total depth of the temples group is 64.6 feet. This value is completely consistent with the distance between the existing halberd gate and the back wall of the temple (that is, the total depth of the two gaps is 67.5 zhangs minus the width of the tunnel behind the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple of the temple Scheme V was finally approved by Emperor Shizong of Ming Dynasty, and the reconstruction project of Taimiao entered the preparatory stage of the project. It is expected to start in the spring of the 14th year of Jiajing (1535). At this point, all the intentions of the Ming Shizong to transform the ancestral temple into a palace hall have been implemented in the planning, but another important intention of the Ming Shizong to initiate the temple system reform, that is, the relocation of the temple, has not been reflected in the above design process.

Moving in and Design of the World Temple

According to the Regulation of the World Temple on the 8th day of February in the 14th year of Jiajing (1535) included in Gui Zhou Memorial, it seems that the idea of the moving in and specific regulation of the World Temple in Ming Shizong started a little late, more like a parallel project with the transformation of the Imperial Temple Palace. Some studies believe that in the design of the Imperial Palace of Taimiao, there are four groups of buildings, namely ShiShi Temple and Sanzhao Temple, on the left, while Sanmu Temple is on the right. The land opposite to ShiShi Temple may be the location reserved by Shizong in Ming Dynasty for Ruizong. But in fact, in the paintings of the ancestral temple of Shizong in the Ming Dynasty, the temple was always the capital palace for itself. At this stage, there was no attempt to merge the God of Ruizong into the capital palace of Taimiao. In terms of etiquette, even after the reign of Emperor Ruizong in the 17th year of Jiajing (1538), there was at most a dispute with the ranking of Wu Zong, and there was no reason to directly override the three Mu. From the architectural point of view, the existing temple at that time occupied a large area, and its main building was regulated according to the Wenhua Temple ("In the east of the brick city, within the imperial city, the south city is as far north as possible or a temple is set up in the east. The porch of the bedroom door behind the front hall is like the Wenhua Hall "), which is much larger than the planned Zhaomu Temple in the Imperial Palace and the planned Wenzu World Room. If we must move into the extremely cramped space of the Imperial Temple Palace, it will inevitably lead to a situation that the regulation of the new world temple is not as good as that of the existing one, which is absolutely unacceptable to Ming Shizong. Therefore, the hypothesis that the virtual master treats the Rui Sect is debatable.

The early planning of the New World Temple is not recorded in the literature. By the time Xia Yan published "Rules and Regulations on the Temple of the World" in the 14th year of Jiajing (1535), the design of the World Temple had actually begun. According to the imperial edict of Emperor Shizong of the Ming Dynasty, "The World Temple proposed by Qing et al. yesterday was regulated in the east of Taimiao, and trees could not be moved", indicating that the World Temple was originally located on the land adjacent to the east side of Taimiao Dugong. For the sake of cutting down trees as little as possible, Emperor Shizong of Ming Dynasty finally chose Xinshi Temple as "a wide place in the southeast of the ancestral temple … which stops at Shenshen Road in the north and reaches the east wall of Chengtianmen in the south, with a total length of 63 feet and 3 feet". However, the Xinshi Temple is not adjacent to the Great Wall of the Imperial City, but only occupies the northern part of the land: "The depth of the north and south … is 35 feet and 9 inches, and the width of the temple street in the south is 27 feet and 4 feet". In this way, the Xinshi Temple is actually embedded in the gap between the Imperial Palace and the east channel of the Imperial Temple, and its overall pattern is not plentiful (Figure 8). In the 22nd year of Jiajing (1543), the Imperial Palace was destroyed by fire. After a site survey, Yan Song made a more detailed description of the site selection pattern of the surviving Xinshi Temple (then known as Ruimiao Temple), saying that "another waist wall outside the east wall of Ruimiao Temple is near the deep ditch. This ditch is the way for the inner imperial city to pass water … It is found that the base of the old temple is more than 63 feet across, and now the ground is added to the ditch in the east wall, which stops at 19 feet. " It is conceivable that the New World Temple, which is only 19 feet wide, is arranged in this gap, and its width is 17 feet wide.

Fig. 8 The site selection data of the World Temple mentioned in Xia Yan’s recitation on the eighth day of February in the 14th year of Jiajing (1535).

Left: Existing land; Right: Planned land use

It is further pointed out in "Rules and Regulations on the Temple of the World" that the original design of the Temple of the World was "nine front halls, seven rear bedrooms … seven in front of them … seven in back … five in back … five in halberds … and its rules and regulations are almost the same as those of the ancestral temple. Considering the narrow scale of the land used for the New World Temple, this design may mean a particularly compact opening rhythm (this compact opening rhythm to ensure the number of rooms can be seen in the Jingdechong Temple, the imperial temple in Beijing, which was also created for the ritual system of Jiajing Dynasty). Why this design was finally abandoned has not been mentioned in the literature.

The regulation of the architecture of Xinshi Temple was finally determined as seven front halls, five rear bedrooms, five front two bedrooms, three rear two bedrooms and five halberds. The specific scale of each single building is attached with pictures, but unfortunately it has not been handed down from generation to generation. After that, Emperor Shizong of the Ming Dynasty said that "the height of the temple should be adjusted from now on, and the rest should be adjusted according to the plan", which seems to have been adjusted in detail. Only the follow-up information has not been published in the literature.

Strengthening the regulation of Taizong temple and the architectural design of each temple

Before the actual construction of Jiumiao Dugong, its design underwent another adjustment, the main purpose of which was to increase the temple regulation of Taizong Temple and make it different from Zhaomu Temple. In Reconsidering the Rules and Regulations of Seven Temples in the 13th year of Jiajing (1534), Xia Yan introduced a fine-tuning scheme, trying to heighten the Taizong Temple without changing the established graphic design of the scheme. Generally speaking, there are many ways to improve the design height of a temple, and the height can be found on the abutment, column height, paving layer and roof elevation. However, the lifting height of the large wooden structure is generally limited by the depth ratio of the temple, and it is impossible to increase it arbitrarily. In the graphic design scheme of Taizong Temple, which covers the same area as Zhaomu Temple, "because the base site is the same, it is difficult to worship Dongyu". In this fine-tuning scheme, the front hall and the sleeping hall of Taizong Temple are barely one foot, four inches, five minutes and five inches higher than those of the group temples. This symbolic increase is difficult to observe with the naked eye in the Jiumiao complex with high building density.

Fig. 9 Scheme VI mentioned in Xia Yan’s recitation on October 23rd, 13th year of Jiajing (1534) in Gui Zhou Memorial.

Left: Existing land; Right: Planned land use

Therefore, Emperor Shizong of the Ming Dynasty immediately requested that "the imperial ancestor Taizong’s family room should be added again". Therefore, Xia Yan and others decided to adjust the plane pattern of Jiumiao building complex again, expand the scale of Taizong Temple, reduce the depth of the temple group from 16.15 feet in the plan to 16 feet, and merge the vacated space into the land for Taizong Temple, so that the depth of Taizong Temple reached 16.6 feet, providing space for the worship of the temple. After the above adjustments, this version of the floor plan (numbered scheme ⅵ in this paper) was finally determined as the implementation scheme of Jiumiao Dugong (Figure 9).

After this adjustment, the temple regulation of Taizong Temple was finally able to distance itself from Zhaomu Temple. The increasing degree of the design data of the single hall of Taizong Temple mentioned in the recitation can also reverse the design scale of the group temple buildings, which is summarized in Table 1:

Table 1 The design data of Taizong Temple mentioned in Xia Yan’s recitation on October 23rd, 13th year of Jiajing (1534) and the design data of each group of temples deduced from it.

palace hall

Wide face (Zhang)

Depth (Zhang)

Tonggao (Zhang)

Taizong temple front hall

7.759

4.009

5.495

Qunmiao qiandian

7.59

3.759

5.05

Taizong temple sleeping hall

6.009

2.395

3.575

Qunmiao rest hall

5.84

2.259

3.375

Through site adjustment, the height of the front hall of Taizong Temple is 0.445 m higher than that of Zhaomuqun Temple, and the height added on the abutment is 0.1 m, which shows that the height added on the wooden structure or tile is 0.345 m.. The height of the sleeping hall of the world room is 0.2 zhangs higher than that of the sleeping hall of Zhaomuqun Temple, and the height added on the abutment is 0.1 zhangs, which shows that the height added on the wooden structure or tile is also 0.1 zhangs.

With the actual progress of the reconstruction project, Xia Yan further detailed the dimensions of the Ming rooms in front of each temple in his "Sketch of the Regulation of Objects in Jincheng Ancestral Temple" on the third day of August in the 14th year of Jiajing (1534). These data are helpful to further restore the architectural design in the new temple system (Figure 10).

Fig. 10 Scale summary diagram of newly-built temples and courtyards in Gui Zhou Memorial and its pattern restoration hypothesis.

According to the architectural pattern design of the temples put forward by Ming Shizong in September of the 13th year of Jiajing (1534), "There are five front halls, with the tiger seats backward, and three bedrooms are connected after the zhangs". It is speculated that in the final implementation plan of the transformation of the ancestral temple, both the ancestral temple and the Zhaomuqun temple are only the front halls and the rear bedrooms, and there are no two guards and halberds. As for the tiger-seat eaves behind the front hall, it is a common practice in temples and ritual buildings in the Ming Dynasty, and it should be as wide as the Ming Dynasty, but its exact depth has not been recorded in the literature. In Figure 10, the images are expressed by dotted lines. The scale of the World Temple is longer than that of other newly-built temples to accommodate the Jimen and the two temples, and its overall pattern is similar to that of the main courtyard of the Imperial Temple. The width and height of the front and rear halls of the World Temple are not recorded in Gui Zhou Recital, but it can be seen from the Sketch of the Regulation of Objects in Jincheng Ancestral Temple that the scale and depth of the Ming Dynasty (the "depth of the Ming Dynasty" recorded in this sketch is actually the total depth of the building) are obviously larger than those of Taizong Temple and Zhaomu Temple.

With regard to the architectural design of the temples and bedrooms, except for the World Temple, given that the front halls of each group of temples are five rooms wide, according to the common practice of temples in the Ming Dynasty, if the other rooms have equal spans, the dimensions of other rooms of these buildings can be calculated from the Ming Dynasty. With reference to the architectural examples of the Ming Dynasty and the existing buildings of the ancestral temple, on the premise that the existing single building of the ancestral temple complex has a saving distance of no more than 11 doukou, assuming that the saving distance of the newly-built temples is 11 doukou, it can be further inferred that the materials used are as shown in Table 2:

Table 2 Speculation on the Ming scale and timber scale of newly-built temples

build

bay

Width (feet)

Presumptive saving equivalent number

Calculate the saving distance (feet)

Estimated bucket mouth value (inch)

Estimated design bucket mouth value (inch)

Taizong temple front hall

Mingjian

23.59

seven

3.37

3.064

three

Other rooms

13.5 (Extrapolation)

four

3.375

3.068

Qunmiao qiandian

Mingjian

22.9

seven

3.271

2.974

three

Other rooms

13.25 (calculation)

four

3.3125

3.011

Shimiaoqiandian

Mingjian

25

seven

3.571

3.247

3.25

The regulation of sleeping halls in newly-built temples is rarely recorded in the literature, and there is no data on the scale of Ming Dynasty. However, considering the design rules of the building complex, its materials should be the same as the corresponding front hall. At present, each single building on the central axis of the ancestral temple is 4 inches, and the newly built temples adopt smaller buckets, which is also consistent with the intention of "respecting the ancestors" in Jiumiao Dugong. The width and depth of each hall are all zero, especially ending with nine points and nine inches. In addition to the auspicious factors, it is likely to include the consideration of the side feet of eaves columns in order to obtain a more complete size in the paving layer and roof.

Fig. 11 Presumption on the standing of the front and back temples of Jiajing Taizong Temple (World Room)

The literature does not specify the height of each temple abutment and the roof shape, and this paper does not focus on restoring the single building shape of each temple. Generally speaking, judging from the ratio of the height to the depth, the front hall of Taizong Temple and the front halls of all temples should be double eaves, otherwise the roof height or abutment height will be too high. In the Ming Dynasty, the proportion of halls and halls was wide and flat, and in extreme cases, the height of eaves and columns could only reach about 60% of the width of rooms and halls. Assuming the front hall of the Temple of Etai, the eaves column is about 14.16 feet high, and the height of the golden column is about 26.9 feet if calculated by 1.9 times the eaves column. Assuming that the depth of the front hall of Taizong Temple is 4.009 feet, the depth of the secondary steps accounts for two distances before and after, and the upper eaves are paved with seven steps and a single elevation, the depth of the upper eaves is about 2.673 feet. According to the roof height of 3: 1 and the abutment height of 6 feet, a draft design of side vertical sample can be obtained (Figure 11). Considering the height of the ridge tiles of the temple, the height of the temple can basically be consistent with the ruler contained in the literature, and the proportion is reasonable.

On the national etiquette system from the perspective of the nine temples project

Decision-making and planning principles of buildings

The design process of Jiajing’s renovation of ancestral temple revealed some renovation principles of large-scale buildings such as national altar temple in Ming Dynasty. The graphic design of national large-scale buildings in Ming Dynasty followed a series of laws of scale and proportion, which was discussed in detail by Mr. Fu Xinian in the article "Characteristics of Master Planning Techniques of Beijing Palace Temple and other large-scale buildings in Ming Dynasty". On this basis, the Research on Architectural Design of Beijing Imperial Temple further points out that the two walls inside and outside the main body of the Imperial Temple, and the walls and individual building scales all cooperate with each other, such as the width of the outer wall is equal to the depth of the inner wall, and so on.

However, this carefully constructed plane pattern was once challenged unprecedentedly when Jiajing rebuilt Jiumiao Temple. A series of preliminary process schemes sorted out in the above article have interfered with the original pattern of the ancestral temple complex to varying degrees. The author speculates that in Jiajing period, the design data of Yongle Zhaozao ancestral temple and Hongzhi Zengjian temple may have been missing, and some precise intentions in the initial graphic design are no longer known. The opportunities for ministers and workers to actually contact the ancestral temple space are extremely limited, and it is even more difficult to understand the proportion and modulus contained in its plane pattern. Interestingly, the subsequent design deepening process of Jiumiao complex happened to be a process of gradually returning to Yongle-Hongzhi plane planning. In the early planning, the disturbance to the original plane was gradually reduced and neutralized, and finally, the principle of design under the original plane framework was completely established. As for the reasons behind this process, on the one hand, it is the guidance of the planning principle of "minimum intervention in plane" determined by Emperor Shizong of Ming Dynasty, on the other hand, it may also be that the officials and ministers gradually realized the intention of the original plane design of Yongle-Hongzhi in the round of deepening the plan. Judging from the fact that the gate wall of the Temple of God, which was built in the 24th year of Jiajing (1545), still follows this plane frame, the original design intention of the ancestral temple complex should have been clearly understood by the monarch and his ministers at that time.

With the help of the above planning and design, we can also get a glimpse of the decision-making process of the transformation of a group of buildings located at the top of the national etiquette system in Ming Dynasty. In this process, it is particularly noteworthy that the emperor’s auxiliary ministers participated in the planning. It is generally believed that the design process of large-scale official construction projects in the history of ancient architecture in China is significantly different from that in the West. In the west, architects with independent professional status often intervene in official or royal projects by participating in bidding and accepting entrustment. The deepening, promotion and adjustment of the design scheme form a complete cycle of creation, cooperation and game, which is closer to the mode of contract signing by Party A and Party B in contemporary construction projects. In ancient China, however, the role of national engineering architect was much more vague. On the one hand, it was undertaken by the emperor himself as the project decision maker, on the other hand, it was undertaken by the craftsmen and wood factories as structural engineers and builders, and there seemed to be a lack of a docking layer between them. However, by observing the design process of Jiumiao architectural complex in Jiajing period, it can be found that the auxiliary ministers around the emperor played an important role in the decision-making of specific engineering projects, although they did not necessarily have a civil knowledge background. On the one hand, they had the opportunity to listen to the emperor’s instructions on the project planning principles and put forward their opinions. On the other hand, their direct reconnaissance of the project site also formed the basis for further design work. Before the specific project is truly assembled, there may be many schemes put forward by them for discussion and deepening. These steps make up for the "design" gap between planning and construction; The construction engineering literacy of the auxiliary ministers constitutes the "group role" of the ancient architects in China.The important attribute of "X" is worthy of further analysis in future research.

Residual theory

Scholars such as Mr. Fu Xinian and Yan Kai have found that the graphic design of the ancestral temple in Beijing adopts a square grid of 50 feet as the basic module, and tried to restore the original design scale of the ancestral temple through modern surveying and mapping data. However, all kinds of scale data in the design process of the reconstruction of the ancestral temple mentioned in Xia Yan and others’ notes can undoubtedly push this exploration forward.

If we compare the scales in documents related to Jiajing’s transformation of ancestral temple with those restored by Fu Xinian and Yan Kai (Table 3), we will find that the scale data obtained from reconnaissance in historical documents do not completely correspond to the modulus of five feet, and are often not integer feet. On the one hand, it shows that there may be differences between ancient surveying and mapping accuracy and design accuracy, on the other hand, it also shows that plane modulus is not the only design principle of large-scale buildings. The engineering and cognitive factors behind this need to be further explored.

Table 3 Comparison of document scale, measured reduction scale and design reduction scale of Taimiao building complex

Documents and Calculation Scale in Jiajing Period (Zhang)

Modern measured scale (Zhang)

Design reduction scale (Zhang)

The wall goes deep from north to south.

81.2

85.3

eighty-five

The interior wall goes deep from north to south.

64.6

65.22

65

East-west width of big wall

63~64

65

65

East-west width of interior wall

34.2~35.2

36

36

Width of tunnel behind the temple

2.9

2.5

Jimen Square goes deep.

13.7

17.5

Compartment width

14.4

14.5

14.5

Most of the literature data are in good agreement with the measured reduction data, and the measured reduction scale is generally slightly larger than the literature scale. Considering that the modern surveying and mapping data and square modulus analysis adopted by Mr. Fu Xinian are based on the wall skin, these deviations may mean that the surveying and mapping data in the Ming Dynasty literature are based on the wall centerline. The difference of the above data is generally within the control range of the project, except for the item of the depth of the great wall of Taimiao complex from north to south, there is a significant difference of about 3.8 zhangs between the document scale and the actual scale, and this difference is caused by the difference of the depth of Jimen Square. This shows that at some point since the transformation of the ancestral temple in Jiajing period, the southern wall of the ancestral temple has indeed been expanded to the south. When did this expansion happen? Was it when the ancestral temple was rebuilt in the 22nd year of Jiajing (1543) or when the river bridge in front of Jimen Gate was expanded in the 28th year of Qing Qianlong (1763)? If the south wall of the existing ancestral temple is retracted 3.8 feet to the north, the geometric center of the formed large wall will fall on the front eaves of the enjoyment hall. Is this the original design intention when the ancestral temple was founded in Yongle period? These are still problems to be solved.

In the 24th year of Jiajing (1545), the episode of Nine Temples finally ended. The ancestral temple complex was restored to the old system, and Ruizong was able to build a temple. This construction history, which is full of subtle considerations of etiquette and personal sustenance, has hardly left any trace in the current ancestral temple, but its meticulous and detailed design process has enabled us to re-understand the operation mode of China’s ancient national project.

Ming Shizong’s idea of changing the temple system has gone through five years from concept to realization. The new temple system is not the arbitrary result of the king, but a mature operation from determining the planning principle, evaluating the conceptual scheme, organizing on-site reconnaissance, submitting the formal design, deepening the comparison and selection, and several rounds of adjustment until the final construction. The design data left in this process has promoted our understanding of the architectural evolution of Beijing ancestral temple. However, the in-depth participation of officials such as Xia Yan shows their architectural engineering accomplishment, which fills the gap in the traditional cognition that there is no architect in ancient architectural design in China.

Brief introduction of the author

Li Weiwen, postdoctoral fellow, doctor of the Palace Museum. His research interests are Beijing urban history and architectural history of Yuan and Ming Dynasties.

WeChat official account’s pictures and texts have been abridged. Please refer to Journal of Architectural History, No.3, 2021 for a complete reading. All rights reserved, please indicate the source. The standard citation format of this article is as follows, please refer to it:

Li Weiwen. The whole process of the reconstruction plan of Beijing ancestral temple in Ming Jiajing Dynasty [J]. Journal of Architectural History, 2021,2 (3): 30-38.

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Original title: "Academic Scholar Li Weiwen: The whole story of the reconstruction plan of Beijing ancestral temple in Ming Jiajing Dynasty"

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　　[Food guide]

　　Seven eating habits: the brain ages slowly, eating like this hurts the heart.

　　Editor’s note:With the improvement of people’s living standards, the requirement for eating has changed from "full" to "good". Faced with a wide variety of foods, how can we eat healthy while satisfying the taste buds? People’s Health Network has tailored a "Guide to Eating" column for "foodies" to make you a healthy "foodie".

　　Seven eating habits, the brain ages slowly.

　　1. Control the heat. Controlling calorie intake can reduce the risk factors of Alzheimer’s disease, such as sleep apnea syndrome, hypertension and diabetes. This is not to suggest that the elderly should cut their calories to a very low level, and it needs to be done step by step. Moreover, it is not recommended that the calorie intake should be less than 1200 kcal/day for a long time, especially for the thinner elderly, otherwise the disadvantages will outweigh the benefits. Old people can start by eating more vegetable salads and vegetable soups, or switch to a smaller plate to give the brain a hint: eat less.

　　2. Eat at least 5 servings (100g/serving) of fruits and vegetables every day. A study of 3,718 volunteers over the age of 65 by the Chicago Health and Aging Research Project in the United States found that eating more fruits and vegetables can slow down the decline of cognitive ability. The study lasted for six years, and the results showed that the elderly who ate more than five servings of fruits and vegetables every day had a 40% lower probability of cognitive decline than others. It is recommended that the elderly in good health eat 300~500 grams of vegetables and 200~350 grams of fruit every day.

　　3. Use rich natural spices. All kinds of plant spices can add flavor to meals, and also help to reduce the amount of edible oil and salt used in cooking. Many plant spices contain antioxidant substances and have certain disease prevention effects. It is suggested that the elderly might as well use natural spices such as onion, garlic, pepper, pepper, mint and cumin in their daily lives to replace some oil, salt and sugar.

　　4. Marinate the cooked meat first. Fat, protein, sugar and other ingredients are widely found in food, and complex chemical reactions occur at high temperature, resulting in the production of toxic and harmful substances such as advanced glycation products, especially in bacon, sausage, processed meat and fried and grilled foods. Eating too much of this kind of food will aggravate brain aging damage. One trick is effective for reducing glycosylation end products: try to increase the water content in food. For example, before cooking fish or meat at high temperature, blanch it in boiling water, or steam and soak it (for example, marinate it with yellow wine, vinegar, soy sauce, etc.) to let water penetrate into the meat.

　　5. Eat deep-sea fish once a week. Fish living in deep-sea waters will produce more omega-3 fatty acids to maintain normal physiological activities in order to keep out the cold. Eating deep-sea fish properly for the elderly can reduce the inflammatory reaction of the body and brain.

　　6. Eat nuts and miscellaneous grains. Whole grains and nuts can supplement omega-3 fatty acids, and are rich in selenium and vitamin E, which can promote brain health. Studies at the University of Washington in the United States show that eating too few grains and nuts is one of the risk factors for premature death. Old people can eat walnuts properly, which contains antioxidants, which can alleviate Alzheimer’s disease. However, it should be noted that a handful of nuts should be consumed every day, and eating too much is easy to exceed the standard of fat.

　　7. Drink several cups of tea every day. Both black tea and green tea are rich in antioxidant catechol, which can prevent oxidation from damaging tissues in all parts of the body. Green tea is rich in catechins, which can reduce β Amyloid deposition lowers blood pressure and cholesterol levels, thus improving brain health. Drinking tea also helps to lower blood pressure and cholesterol levels, and has a positive effect on reducing the risk of type 2 diabetes, cardiovascular disease and ovarian cancer.

　　Skipping breakfast and having dinner too late will hurt your heart.

　　The recently published European Journal of Preventive Cardiology published a new research result in Brazil: skipping breakfast or dinner and having a party directly affects the rehabilitation effect of heart disease patients and increases the risk of premature death after heart attack.

　　In the new study, Dr. Marcus Minicucci, a researcher at Sao Paulo State University in Brazil, and his team investigated 113 heart attack patients with an average age of 60. These patients suffer from a particularly serious heart disease — — ST segment elevation myocardial infarction (STEMI). Among them, 58% patients did not eat breakfast, 51% patients had dinner very late, and 41% patients did not eat breakfast and had dinner too late. Comparative analysis shows that patients who skip breakfast or have dinner too late will have a 4-5 times higher risk of angina pectoris, recurrent heart disease and death within 30 days after discharge than those who have normal meals.

　　According to Dr. Minicucci’s analysis, people who have two bad eating habits, skipping breakfast and eating too late for dinner, are more likely to have other unhealthy habits, such as smoking and inactivity, which will lead to problems such as inflammatory reaction, oxidative stress and decreased endothelial function, further increasing the difficulty of rehabilitation after heart disease. The data show that the mortality rate of STEMI patients is as high as 10% within one year after discharge, and regular intake of adequate nutrition is a simple and easy way to improve the prognosis. It is recommended to eat breakfast on time every day, with at least two hours between dinner and sleep.

　　Ten "Appropriate" Diets for the Elderly

　　Scientific diet is the cornerstone of health in old age. The elderly pay attention to 10 "appropriate" diets. The following is a detailed introduction for elderly friends.

　　Food should be mixed. The human body needs to get nutrition from different foods. It is recommended that the elderly choose a variety of foods such as cereals, fruits and vegetables, fish and eggs, milk beans and oils every day, and pay attention to the combination of meat, thickness, color, taste and dryness.

　　Quality should be high. High quality does not mean high price. Taking protein as an example, common milk, eggs, tofu, chicken, duck and fish can provide rich and high-quality protein for the elderly. In the choice of meat, it is recommended to eat more fish and shrimp, and try to use steamed or boiled methods.

　　Fruits and vegetables should be fresh Brightly colored fruits and vegetables often contain antioxidants, which can regulate immunity and prevent chronic diseases. Purple is rich in anthocyanins, such as eggplant; Green ones are rich in chlorophyll and lutein, such as spinach; Yellow is rich in β -carotene, such as citrus; Red ones are rich in lycopene, such as tomatoes.

　　Drinking water should be diligent. Old people’s sensitivity to thirst is declining, so they should form the habit of drinking water consciously. The daily diet should be properly matched with porridge, soup, soybean milk, milk, etc., and 900~1200 ml of water and light tea should be supplemented separately.

　　The quantity should be small. The basal metabolic rate of the elderly is decreasing. The Chinese Physiological Society suggests that the total energy intake of people aged 61-70 can be reduced by 20% compared with that of young adults, and it can be reduced by 30% over 71 years old. Although the amount of food intake is reduced, the variety cannot be less.

　　The food should be fragrant. When you get older, your sense of smell and taste will become dull, leading to a loss of appetite. Therefore, the diet of the elderly should be more refined and pay attention to the collocation of color, fragrance, taste and shape. In addition, the quiet and comfortable dining environment and the form of dining together can improve the dining interest of the elderly.

　　The texture should be soft. Because the secretion of digestive juice, digestive enzymes and gastric acid in the elderly is reduced, it will affect the digestion and absorption of food, so the texture of the food for the elderly is soft and rotten, and cooking methods such as steaming, boiling, stewing, stewing and frying are used.

　　The temperature should be hot. Old people have poor resistance to cold. Once they eat raw, cold and hard food, it will affect digestion and absorption, and even cause diarrhea. The best digestion and absorption process of food is carried out at a temperature close to body temperature, so a warm diet is most suitable for elderly people.

　　The speed should be slow. Chewing slowly is an important way to ensure the crushing effect of food and the health of the stomach, and it is also beneficial to digestion and absorption. In addition, try to "eat without speaking" to prevent food from entering the trachea.

　　The taste should be light. When you get older, cholesterol and triglycerides will inevitably rise, so you need to control oil; The glucose tolerance of the elderly will decline, and sugar needs to be reduced; There are many elderly people at risk of hypertension, so it is necessary to reduce salt. In addition, we should avoid eating pickled food, canned food, fast food and all kinds of cooked food.

　　Children who eat nuts during pregnancy may be smarter.

　　Spanish researchers have found that mothers often eat nuts during pregnancy, which may make their children smarter when they grow up.

　　Researchers at the Barcelona Institute for Global Health have followed 2,200 Spanish children and their mothers for 8 years to reach the above conclusion. The interviewed mothers answered about the diet during pregnancy, especially whether they ate nuts such as walnuts, almonds, peanuts, pine nuts and hazelnuts during pregnancy. Children were tested at the age of one and a half, five and eight, so that researchers could examine their cognitive development.

　　After taking into account the mother’s education level, social class and other eating habits, the researchers found that children whose mothers ate nuts during pregnancy performed better than other peers in all stages of the test. The data showed that the mother ate 30 grams of nuts every week in the first three months of pregnancy, and the average score of the child after birth was 3% higher in the test aimed at examining short-term memory, concentration time and cognitive function. Jordi Julves, a researcher, was quoted by The Times on the 8th as saying that this is equivalent to a score of 3 points higher in the IQ test. Although this number sounds small, it is very important to the whole population. "In this way, the number of children with learning disabilities will be greatly reduced, and there will be more children with super high IQ."

　　☆ Recommended reading ☆

　　People’s health APP people’s good doctor APP

　　Recommended reading

　　What are the thresholds for home care in the pilot project of "network nurses" in March? Injection, venous blood collection, wound dressing change … … In the past, these common medical services had to be carried out in hospitals or communities. For disabled people or patients with mobility difficulties, it is still very inconvenient without the help of their families. In recent years, with the rapid development of the mobile Internet, "online nurses" have begun to enter people’s lives. Just click on the mobile APP and you can enjoy convenient on-site service for nurses. On February 12th this year, National Health Commission officially issued the Notice on Launching the Pilot Work of "Nursing Service in internet plus" and the pilot scheme, and decided to pilot "Nursing Service in internet plus" in Beijing, Tianjin, Shanghai, Jiangsu, Zhejiang and Guangdong from February to December this year. Now, it has been more than two months since the promulgation of the notice. What progress has been made in the pilot work and what problems are faced?

　　Developing these good habits will keep you healthy for a lifetime. A few bunches of grapes can make the skin more delicate, and a cup of green tea can make the hair thicker. The "Body Repair Recipe" recently published by British magazine Charm points out that certain foods can make your body healthier and more perfect.

State and municipal people’s governments, provincial committees, offices, departments and bureaus:

"Yunnan Province" 14 th Five-Year Plan "for the Innovation and Development of Biomedical Industry has been agreed by the provincial people’s government and is hereby issued to you, please implement it carefully.

General Office of Yunnan Provincial People’s Government

March 17, 2022

(This piece is publicly released)

In order to accelerate the innovation and development of the biomedical industry, this plan is formulated according to the 14th Five-Year Plan for National Economic and Social Development in Yunnan Province and the Outline of Long-term Objectives for the Year 2035, combined with the reality of our province.

I. Development Status and Situation

(A) Development effectiveness

During the "Thirteenth Five-Year Plan" period, the provincial party committee and the provincial government conscientiously implemented the spirit of the important speech of the Supreme Leader General Secretary on his inspection of Yunnan, and on the basis of continuously building eight key industries and world-class "three cards", put forward the strategic deployment of focusing on cultivating five trillion-level pillar industries and eight billion-level advantageous industries and building a modern industrial system. Biomedical industry, as a strategic emerging industry with a focus of 100 billion yuan in our province, has steadily expanded its scale, significantly enhanced its innovation ability, increasingly optimized its policy environment, and continuously improved its economic benefits. Its operating income increased from 124.109 billion yuan in 2015 to 252.145 billion yuan in 2020, with an average annual growth rate of 15.23%, and its added value increased from 36.587 billion yuan in 2015 to 73.14 billion yuan in 2020. The average annual growth rate reached 14.86%, the business income and added value doubled, and a research and production system of biotechnological drugs focusing on vaccines was gradually formed, and a whole industrial chain development system of natural drugs (ethnic Chinese medicines) featuring proprietary Chinese medicines, Chinese herbal pieces, extracts and health products was established.

In 2020, the province’s Chinese herbal medicine planting (breeding) industry will realize an operating income of 51.611 billion yuan; The biomedical manufacturing industry realized an operating income of 59.592 billion yuan; The biomedical commerce and trade industry realized an operating income of 140.942 billion yuan. There are 163 pharmaceutical manufacturing enterprises above designated size (including 1 enterprise with operating income exceeding 10 billion yuan and 5 enterprises with 1-10 billion yuan). There are 48 varieties with sales income exceeding 100 million yuan (including 5 varieties exceeding 1 billion yuan and 4 varieties with 500-1 billion yuan). Up to now, there are 9 biomedical enterprises listed on the main board and growth enterprise market in the province.

1. The biotechnology pharmaceutical industry has made breakthrough development.

In 2020, the province’s biological products manufacturing industry above designated size represented by vaccines achieved an operating income of 5.357 billion yuan, accounting for 15.6% of the operating income of pharmaceutical manufacturing industry above designated size. There are 13 vaccine varieties on the market, and the operating income of vaccine enterprises has increased from 800 million yuan in 2009 to 4.8 billion yuan in 2020, and the biotechnology drug industry has made breakthrough progress. The inactivated enterovirus 71 vaccine independently developed by the Institute of Medical Biology, Chinese Academy of Medical Sciences was launched in December 2015, and the annual operating income of a single variety was nearly 2 billion yuan. The 23-valent pneumococcal polysaccharide vaccine developed by watson biological was launched in July 2017, with an operating income of 688 million yuan in 2020; The first trivalent pneumococcal polysaccharide conjugate vaccine in China and the second trivalent pneumococcal polysaccharide conjugate vaccine in the world went on the market in April 2020, with an operating income of 1.658 billion yuan in the first year, and the market prospect is considerable. Some traditional pharmaceutical companies and scientific research units have accelerated the layout and development of biotechnological drugs. Suparutide injection, a long-acting hypoglycemic drug developed by Kunyao Group, has obtained clinical approval, and Sino Pharmaceutical has carried out research on new drugs of humanized CD22 antibody immunotoxin 1.1.

2 Chinese medicine (ethnic medicine) industry scale

In recent years, the traditional Chinese medicine (ethnic medicine) industry in our province has become the main force to promote the development of biomedical industry from small to large and from weak to strong. 60 "Hometowns of Yunyao" and 103 "Pharmaceutical Parks" have become the new force to improve the quality and brand of Chinese herbal medicines. In 2020, the main business income of planting (breeding) and product processing of Chinese herbal medicines in the province will exceed 100 billion yuan, among which the processing and manufacturing of Chinese herbal medicines above designated size, such as proprietary Chinese medicines, Chinese herbal pieces, extracts and health products, will achieve an operating income of about 48 billion yuan, accounting for over 80% of the main business income of biomedical industries above designated size. The planting area of Chinese herbal medicines exceeds 9 million mu, the planting area of 15 varieties of Chinese herbal medicines, such as Panax notoginseng, Paris polyphylla, Dendrobium, Amomum villosum and Radix Aucklandiae, exceeds 100,000 mu, and the standardized planting base of Chinese herbal medicines covers an area of 1.46 million mu, including 22,000 mu of green certification base and 126,000 mu of organic certification base. Sanqi, Erigeron breviscapus industry has formed a whole industrial chain layout of planting, processing, R&D and production, which has played a very prominent role in demonstrating the development of traditional Chinese medicine industry in the province. Panax notoginseng industry has achieved standardization and standardized planting, and developed relatively complete back-end products such as decoction pieces, preparations and health products, which has become a big variety second only to ginseng. The planting area of the whole province is about 400,000 mu, and the agricultural output value is about 6 billion yuan. A number of Chinese patent medicines and injections such as Panax notoginseng decoction pieces, Xuesaitong soft capsules, Xuesaitong for injection (freeze-dried powder injection), Xuesaitong tablets, Xuesaitong capsules, Panax notoginseng saponins and Xuesaitong injection, etc.

3. The chemical medicine industry has developed steadily.

In 2020, the chemical preparation manufacturing industry and the chemical raw material medicine manufacturing industry above designated size will realize an operating income of 3.52 billion yuan, accounting for 10.2% of the pharmaceutical manufacturing industry above designated size. Initially gathered a number of chemical pharmaceutical enterprises such as Jida Pharmaceutical, Baker Norton, Haobang Pharmaceutical, Sino Pharmaceutical, Longhai Pharmaceutical and Guiyan Pharmaceutical; Longjin Pharmaceutical, Haobang Pharmaceutical and Plant Pharmaceutical cooperated with Indian generic drug companies to actively introduce Indian generic drug varieties to Yunnan; Nine varieties, including amoxicillin capsules, chlorphenamine maleate tablets and ambroxol hydrochloride injection, passed the consistency evaluation of chemical generic drugs.

4. Remarkable achievements have been made in biomedical science and technology innovation.

Driven by scientific and technological innovation, the biomedical industry has gradually embarked on a high-quality development track. Sabin inactivated poliomyelitis vaccine, EV71 inactivated enterovirus vaccine, 13-valent pneumococcal polysaccharide conjugate vaccine and other fist products have been listed one after another, and some varieties are undergoing WHO pre-certification; Covid-19 inactivated pneumonia vaccine, F gene mumps live attenuated vaccine, nine-valent human papillomavirus (HPV) vaccine, rotavirus inactivated vaccine and tetravalent meningococcal polysaccharide conjugate vaccine are in the clinical research stage, which has provided strong support for the rapid development of the vaccine industry during the Tenth Five-Year Plan. Ten innovative drugs, such as KPCXM18, a natural medicine for treating ischemic stroke, Duanjin Jiedu Capsule, a 6-class Chinese medicine, Suparutide injection, and a 1.1-class new drug of bungarus multicinctus venom, were approved by the national drug clinical approval. Winona series products, with authentic Yunnan medicinal materials as the main raw materials, have developed into an important functional skin care brand in China. "Key Technology Creation and Industrial Application of Comprehensive Development of Panax notoginseng" won the second prize of National Science and Technology Progress Award, "Key Technology and Application of Standardization and Industrial Development of Panax notoginseng" won the first prize of Yunnan Science and Technology Progress Award, and three standards of Panax notoginseng, seeds and seedlings and Gastrodia elata passed the international quality standard certification. Panax notoginseng saponins and breviscapine have passed GRAS (generally considered safe) certification recognized by FDA, and entered the catalogue of American botanical medicine raw materials;Tongshu capsule and Xuesaitong soft capsule were approved by FDA to carry out phase II clinical research.

Around the great demand of the development of biomedical industry, a number of R&D service platforms have been built, such as Yunnan Biovaccine Technology Innovation Center, Yunnan Drug Non-clinical Safety Evaluation Research Center, Yunnan Natural Drug Activity Screening and Evaluation Center, Yunnan Stem Cell and Regenerative Medicine Research Center, Yunnan Flower Aromatic Health Products R&D Center, and Yunnan Chinese Medicine Seed Breeding R&D Center. By the end of the 13th Five-Year Plan, there were 47 provincial key laboratories in the biomedical field, 20 engineering technology research centers, 19 engineering research centers, 10 clinical medical research centers and 4 academicians of the two academies in the province, and 12 provincial science and technology leaders were trained, 54 provincial high-level talents were introduced, 4 high-level innovation and entrepreneurship teams were introduced, 553 provincial young and middle-aged academic and technological leaders and 553 provincial innovative talents were trained.

5. Bio-pharmaceutical industry has achieved initial results by attracting big and strong players.

Yunnan Baiyao Group introduced social capital to complete the mixed reform, and the development of the group entered the fast lane; China Resources Sanjiu acquired Kunming Shenghuo Pharmaceutical, and the company’s operating income increased significantly; Guizhou Bailing invested in Yunnan plant pharmaceutical industry, focusing on characteristic products, optimizing product structure, and implementing large-variety brand strategy. The scale of the enterprise has maintained rapid growth for many years. Well-known enterprises inside and outside the province, such as Sinopharm Group, Shanghai Pharmaceutical Group, Guangzhou Pharmaceutical Group, Tasly Pharmaceutical, Kangenbei Pharmaceutical, Shenwei Pharmaceutical, New Green Pharmaceutical, Beijing Tongying, Fangsheng Pharmaceutical, Jilin Xingshen, Hong Kong Juzhang and Shenzhen Botton, have landed in Yunnan and actively participated in the healthy development of the biomedical industry.

(B) Advantages and shortcomings

1. Location advantage

Yunnan has outstanding geographical advantages. It is adjacent to Guizhou and Guangxi in the east, Sichuan in the north, Tibet in the northwest, and Myanmar, Laos and Vietnam in the west and south. It is an important channel connecting South Asia, Southeast Asia and the Indian Ocean region, and an important intersection of the "Belt and Road" construction and the national development strategy of the Yangtze River Economic Belt. The biomedical industry has a huge potential market, which can be built on the basis of vaccines and traditional Chinese medicine (ethnic medicine)

2. Resource advantages

Yunnan has obvious three-dimensional climate characteristics, many types, beautiful mountains and rivers, pleasant climate and outstanding biodiversity characteristics. It is known as the "plant kingdom", "animal kingdom", "microbial kingdom", "hometown of medicinal materials" and "treasure house of biological genes", and is the province with the richest biological resources, natural medicines and ethnic medicine resources in China. According to the statistics of the third national survey of traditional Chinese medicine resources, there are 6,559 kinds of traditional Chinese medicine resources in the province, accounting for 51.4% of the total number of kinds in the country, more than 2,000 kinds of ethnic medicine resources and more than 10,000 folk prescriptions.

3. Advantages of industrial base

Notoginseng Radix, Rhizoma Paridis Yunnanensis, Erigeron breviscapus, Dendrobium candidum, Fructus Amomi, Rhizoma Gastrodiae, Poria Yunensis, Radix Angelicae Sinensis, Radix Aucklandiae, Radix Gentianae Yunnanensis and other "Top Ten Yunyao" brand medicinal materials have excellent quality and are widely recognized in the industry. It has built a domestic raw material base for high-quality natural medicines and health products. The large varieties of Yi medicine represented by Yunnan Baiyao, the unique ethnic medicines such as Dai and Naxi, and the unique ethnic medical technologies such as Dai medicine, which are in the same strain as the traditional medical systems of neighboring countries, provide rich ethnic medical resources for the innovation, inheritance and development of traditional Chinese medicine and the opening up of markets for South Asian and Southeast Asian countries. Gu Fangzhou, known as the "father of polio vaccine in China", engaged in the research of live attenuated polio vaccine in Yunnan, established the method of isolation and finalization of polio virus, formulated the trial production and safety standards of live polio vaccine, and formulated the "Rules for the manufacture and verification of live polio vaccine", which guided the production and identification of billions of vaccines in China and laid a solid foundation for the rapid development of vaccine industry in our province.

4. Shortcomings of rapid industrial development

First, the industry is small in scale and weak in competitiveness. The overall scale of Yunnan’s biomedical industry is small. Among the top 500 main business incomes of the national pharmaceutical industry, there are only 10 in Yunnan. The overall competitiveness of the biomedical industry, which is dominated by traditional Chinese medicine, is weak, especially affected by the national medical reform policies such as the catalogue of auxiliary drugs of traditional Chinese medicine, the catalogue of medical insurance, and the consistency evaluation of traditional Chinese medicine injections. The scale of biomedical manufacturing industry has declined slightly for two consecutive years.

Second, the industrial structure is not excellent and the industrial chain is incomplete. The development of standardized planting (breeding) bases of Chinese herbal medicines lags behind, the phenomenon of small varieties of Chinese herbal medicines is prominent, the research foundation is uneven, and the competitiveness of products is generally weak; Vaccines are the main biotechnological drugs, but the pipelines of antibody drugs, biological similar drugs, cell products, blood products and other products are not rich, and the upstream and downstream supporting industries are basically blank; Small amount of chemicals, lack of original research drugs and high-end generic drugs; The development level of medical devices and veterinary drugs is low.

Third, the core competitiveness of enterprises is weak, and the degree of specialization of the park is low. There are few well-known enterprises and leading enterprises, leading enterprises are not aware of advanced layout and innovative R&D activities, and the industry is not leading enough; Insufficient investment in research and development, lack of influential and innovative varieties, and weak core competitiveness; The level of professional development of biomedical industrial park is not high, the supporting system is not perfect, and the public R&D and service capabilities are weak.

Fourth, innovation ability is not strong, and high-level talents are lacking. The research and development system of new drug creation is imperfect, the resources are scattered, and the technical level is not high, which does not match the needs of the industrial chain; Lack of forward-looking scientific research ability for common technologies, key technologies and cutting-edge technologies needed for rapid industrial development; There are few innovative products in other industries except vaccines; The linkage between enterprises and scientific research institutions is not close, and the contradiction between supply and demand in the transformation of scientific and technological achievements is prominent; Lack of high-level R&D innovation centers and insufficient public R&D service platforms such as drug safety evaluation (GLP), drug clinical evaluation (GCP) and contract R&D institutions (CRO); There is a serious shortage of high-level innovative talents, management talents and teams.

Fifth, brand building is not enough, and market development ability is weak. Enterprises are weak in coping with industrial policies such as medical reform, drug review and approval, and drug production supervision, and weak in market cultivation and brand building of their own products; There is a lack of systematic publicity highlighting the advantages and characteristics, insufficient excavation of superior Chinese herbal medicine varieties, time-honored traditional Chinese medicine and ethnic medicine culture, and weak brand building and market promotion of "Yunyao".

(3) Opportunities and challenges

1. Health needs are increasing.

With the increase of sub-health population and the acceleration of population aging, people’s demand for health products has increased rapidly; The demand for health consumption has changed from medical treatment to disease prevention, health care and health promotion; The national new medical reform plan puts the prevention and control of diseases in the first place, and pays more attention to "preventing diseases before they occur". Traditional Chinese medicine (ethnic medicine) will be promising.

2. Building a domestic and international dual cycle will bring new opportunities for industrial development.

The COVID-19 epidemic has had a great impact on the global industrial chain and supply chain. It is an inevitable requirement to maintain a stable and healthy economic development by adjusting the economic development path, opening up the international circulation, smoothing the domestic circulation, coordinating development and security, enhancing the autonomy, sustainability and resilience of economic development. Seize the development opportunities brought by the Regional Comprehensive Economic Partnership Agreement (RCEP), make full use of Yunnan’s geographical advantages in connecting South Asia, Southeast Asia and the Indian Ocean region, and exchange the traditional medicine with neighboring countries, realize the smooth connection with the biomedical industry in South Asia and Southeast Asia, and accelerate the construction of a new international and domestic dual-cycle development pattern.

3. The epidemic situation in COVID-19 affected the development pattern of pharmaceutical industry.

After the outbreak of COVID-19, COVID-19’s vaccine research and development and production have become the focus of international competition in the field of biotechnology drugs, which puts forward new requirements for the corresponding research and development technology system, experimental evaluation, manufacturing capacity level and organizational management efficiency. With the development of modern biotechnology such as genetic engineering, cell engineering, tissue engineering, biosynthesis, bioinformatics and precision medicine, biotechnological drugs such as vaccines and antibody drugs have become the main direction of the transformation and upgrading of the biomedical industry. The competitive advantages of prescription and medicine represented by "three drugs and three parties" are prominent, and the modern innovative Chinese medicine with clear mechanism of action and definite clinical effect has obvious competitiveness. The demand for medical materials represented by ventilators, testing reagents, medical masks and protective clothing has surged, which has promoted the development of the medical device industry.

4. Competition in domestic pharmaceutical industry is becoming increasingly fierce.

All provinces (autonomous regions and municipalities) take biomedicine as a priority industry, and Beijing, Shanghai, Jiangsu, Guangdong and other provinces (municipalities) have been at the forefront of the country by virtue of their own geographical, policy, talent and technical advantages; Shandong, Sichuan, Hubei, Jiangxi and other provinces have also accelerated the pace of industrial development, and the competition between regions has become increasingly fierce. The reorganization of enterprises in the industry is frequent, and super-large enterprises are constantly emerging. The development trend of agglomeration is obvious, full of opportunities and challenges.

5. The medical reform policy forces the pharmaceutical industry to develop with high quality.

The research and development, production and sales of pharmaceutical products are highly dependent on policy factors, and the industrial development is deeply influenced by policy regulation. The continuous adjustment of various policies, such as drug supervision, the catalogue of traditional Chinese medicine auxiliary drugs and the new medical insurance catalogue, has prompted pharmaceutical enterprises to increase investment in research and development, take a higher quality development path, change from extensive development to refined development mode, and change products from imitation to original innovation. At the same time, information technology represented by mobile medical care, cloud computing, big data and Internet of Things has begun to penetrate into all aspects of the biomedical industry.

6. Competition for innovative drugs has intensified.

At present, the research and development of major innovative drugs are still led by well-known multinational companies, and the competition for technology, talents and funds in the biomedical industry is extremely fierce. Large pharmaceutical companies focus on developing innovative drugs for clinical value in the fields of biotechnology drugs and chemical drugs, while expanding new indications of existing products and expanding upstream and downstream business chains. Pharmaceutical companies with obvious competitive advantages in core products, diversified products and outstanding R&D capabilities will have stronger competitiveness and anti-risk ability. The global vaccine industry presents an oligopoly pattern, with the top 10 companies accounting for 95.7% of the total vaccine market share, and the four vaccine giants GSK (GlaxoSmithKline), Merck, Sanofi and Pfizer accounting for about 80% of the total market share. In the future, the global vaccine market has great growth potential and will grow rapidly with a compound annual growth rate of 10%. The rapid development of frontier technologies such as gene therapy and cell therapy is expected to form major innovative drugs and new supporting technologies. The patents of the top 10 original drugs in global sales, such as Hummel, Merlot and Avastin, are about to expire, and generic drugs and bio-similar drugs are expected to usher in new opportunities. From the national situation, the major achievements of new drug research and development are mainly concentrated in Beijing, Shanghai, Jiangsu and other places, and innovative enterprises led by new drug research and development, such as Hengrui Pharma and Wuxi PharmaTech, have a strong development momentum.

Second, the development ideas, principles and objectives

(A) development ideas

Guided by the Supreme Leader’s Socialism with Chinese characteristics Thought in the New Era, we will fully implement the spirit of the 19th National Congress of the Communist Party of China and the previous plenary sessions of the 19th National Congress, thoroughly study and implement the spirit of the important speech of the Supreme Leader’s General Secretary on his visit to Yunnan, conscientiously implement the decision-making arrangements of the provincial party committee and government, grasp the new development stage, implement the new development concept, serve and integrate into the new development pattern, adhere to the problem-oriented, goal-oriented and result-oriented, take innovation as the core, quality as the foundation, and take enterprises as the main body. Market-oriented, focusing on the three key areas of biotechnological drugs, modern Chinese medicine and health products, we will focus on attracting investment accurately, strengthening the main body of enterprises, enhancing innovation ability, building industrial clusters, promoting industrial development with engineering measures, building domestic first-class R&D and production bases of biological vaccines and modern Chinese medicine, domestic top-quality raw materials bases of natural drugs and health products, and biomedical trade bases facing South Asia and Southeast Asia, forming an industrial cluster with important influence in the country, and realizing the high-quality development of Yunnan biomedical industry.

(2) Basic principles

1. Innovation-driven, quality-improved development

Around the industrial chain, deploy innovation chain, build a batch of high-level public service platforms and professional R&D platforms, break through a batch of technologies, reserve a batch of achievements, develop a batch of products and transform a batch of achievements, and promote the high-quality development of Yunnan biomedical industry.

2. Based on advantages and outstanding features

Based on the advantages of Yunnan’s location, ecology, environment, resources and nationality, we will highlight the characteristics of biological vaccines, authentic medicinal materials, ethnic medicine, classic and famous prescriptions, proven prescriptions and cell technology, strengthen product quality and standards, and accelerate industrial transformation and upgrading.

3. Government guidance and market dominance

Innovate institutional mechanisms, rationally allocate resources, break through policy bottlenecks, cultivate and expand market players, release enterprise vitality and market potential, and build a sound market system and policy system.

4. Open cooperation and push forward together.

Improve the soft and hard environment, expand the domestic and foreign markets, and support local enterprises to become bigger and stronger; Introduce well-known enterprises and scientific research achievements to expand the increment; Attracting scientific research institutes from outside the province to develop in Yunnan, jointly cultivating talents, focusing on R&D and innovation, and forming a strong synergy to promote industrial development.

(III) Overall objectives

By 2025, the operating income of the biomedical industry will achieve the goal of "ensuring four guarantees and competing for five", that is, it will reach 400 billion yuan and strive to reach 500 billion yuan, with an average annual growth rate of more than 10%. Among them, the biomedical manufacturing industry will achieve an operating income of more than 150 billion yuan, with an average annual growth rate of more than 20%. The added value of biomedical industry reached 120 billion yuan, with an average annual growth rate of more than 10%. Strive for the biological vaccine industry to achieve the number and value of batch issuance. Facing 2035, we will focus on key markets, increase promotion, actively tap the domestic market, vigorously explore the South Asia and Southeast Asia markets, further enhance the influence and market share of the brand "Yunyao", and build Yunnan into a biomedical R&D innovation and product production and trade center with distinctive characteristics of serving the whole country and radiating South Asia and Southeast Asia, and build an industrial cluster with important influence in the country.

-do it on a large scale. By 2025, we will cultivate more than one enterprise (group) with operating income exceeding 50 billion yuan, more than five enterprises (groups) exceeding 10 billion yuan, more than five enterprises (groups) exceeding 5 billion yuan, more than 20 enterprises (groups) exceeding 1 billion yuan and more than 70 enterprises exceeding 100 million yuan.

-strengthen varieties. By 2025, more than 10 varieties with sales income exceeding 1 billion yuan and more than 60 varieties with sales income exceeding 100 million yuan will be cultivated.

-do an excellent structure. By 2025, the leading development of biotechnological drugs will be realized, modern Chinese medicine (ethnic medicine) will be upgraded and developed, dual-use products for medicine and food will develop by leaps and bounds, and chemical drugs and medical devices will make breakthroughs.

-fill in the short board. We will build and upgrade a number of public R&D and service platforms around biotechnology drugs, modern Chinese medicine and chemical drugs, break through a number of key core technologies, and develop a number of competitive and innovative products.

Third, key tasks

Around the biomedical industry chain, deploy innovation chain, promote the organic integration of industry chain and policy chain, innovation chain, capital chain, supply chain, talent chain and value chain, focus on key core technologies, fill the shortcomings of the platform and increase high-quality varieties. Strengthen leading enterprises and enhance manufacturing capacity. Optimize the industrial layout, strengthen the construction of the park, and form industrial agglomeration. Enhance the brand of "Yunyao", revitalize the stock, introduce increments, expand the total amount, and realize the high-quality development of the biomedical industry.

(1) Strengthen varieties and accelerate the transformation and upgrading of biomedical manufacturing.

Give priority to the development of biological vaccines, modern Chinese medicines (ethnic medicines), Chinese herbal pieces and chemical medicines, vigorously develop biotechnological medicines such as antibody medicines, gene technology, cell therapy and blood products, as well as health products, detection and diagnosis reagents, medium and high-end medical devices, strengthen the research and innovation of biotechnological medicines, modern Chinese medicines, natural medicines, generic medicines, new preparations and health care products, and support the internationalization of vaccines, modern Chinese medicines and medical devices. Focusing on increasing investment in scientific and technological innovation, building a number of well-known enterprises and brand products, introducing large enterprises and groups, encouraging enterprises to acquire and merge, and promoting international development, we will promote digital and intelligent manufacturing and accelerate the transformation and upgrading of biomedical manufacturing.

1. Key development areas

(1) Biotechnology drugs focusing on vaccines

The biotechnology pharmaceutical industry focusing on vaccines is the fastest-growing field in the biomedical industry in our province, and efforts should be made to improve the upstream and downstream industrial chains, enhance the research and development capacity of new vaccines, accelerate the construction of a rapid response system for major infectious diseases, strengthen frontier basic research, and enrich product pipelines.

Focus on Kunming and Yuxi to build biotechnology pharmaceutical industrial bases focusing on vaccines, and vigorously develop new biological vaccines, antibody drugs, biological analogues, cell preparations, blood products such as albumin, coagulation factors and immunoglobulin, and other new products of proteins, peptides and nucleic acids. Enlarge and strengthen the existing biotechnology drug enterprises, encourage vaccine enterprises to build digital and intelligent production lines, and improve the production technology level. Guide enterprises in the province to build, acquire and merge R&D institutions at home and abroad, build a quality system, R&D system and production technology system that are in line with international standards, promote the international registration and WHO pre-certification of biological vaccine products, build a vaccine production and supply base that meets international quality standards and a leading domestic monoclonal antibody drug industry base, increase open cooperation with South Asia, Southeast Asia, Africa, Europe and the United States, and open up markets in South Asia, Southeast Asia and the Indian Ocean Rim.

Traditional vaccines: enterprises are encouraged to develop univalent vaccines, multivalent vaccines and multiplex vaccines with attenuated, detoxified and inactivated products based on pathogenic microorganisms and their metabolites, so as to promote the secondary development and upgrading of biological vaccines.

New vaccines: break through the key core technologies such as efficient genetic engineering construction technology of virus species and strains, screening research technology of pathogen antigen components, bacterial polysaccharide-protein binding technology, large-scale animal cell culture technology, new vaccine adjuvant technology, genetic engineering technology, genetic engineering recombination technology, non-human primate model evaluation, and carry out research and development and transformation of new vaccines such as nucleic acid vaccine, synthetic peptide vaccine, genetic engineering vaccine and recombination vaccines. Increase the forward-looking research and development of mRNA technology in the prevention and treatment of infectious diseases, AIDS, genetic diseases, rare diseases, tumors and other major diseases.

Antibody, protein and nucleic acid drugs: develop monoclonal antibody drugs, neutralizing antibodies, bispecific antibodies, antibody-coupled drugs (ADC), biological analogues, recombinant protein drugs, polypeptide drugs and nucleic acid drugs for diseases such as tumor, immune system, cardiovascular and cerebrovascular diseases and infections.

Animal vaccines: Encourage the research and development of veterinary vaccines such as Class A epidemic vaccines, multi-animal co-morbid vaccines, vaccines for cattle and sheep, vaccines for pigs, vaccines for poultry, and vaccines for pets.

Cell preparation: within the scope permitted by policies and regulations, encourage and standardize the research and development of cell therapy products including stem cells and immune cells; We will carry out research on a series of standards and technical systems such as preparation, quality inspection and safety evaluation of clinical-grade cell products and derivatives, improve their safety, effectiveness and quality controllability, and accelerate the research on clinical application norms of cell therapy.

Blood products: introduce and develop blood products, focusing on the development of coagulation factors, thrombin, human albumin, human fibrinogen, immunoglobulin and other products. Within the scope permitted by the policy, the layout of plasma raw materials will be increased by adding plasma collection stations.

Other biotechnologies: Accelerate the construction of a synthetic biotechnology innovation system, support the research on genome design and synthesis, and provide technical support for basic research on new biological treatment methods, vaccines, materials and disease control.

Make use of the advantages of genetic resources in our province to develop the biomedical industry of non-human primates and carry out research on the protection and rational utilization of human genetic resources; Carry out research on transplant organ cultivation technology and xenotransplantation technology.

(2) Modern Chinese medicine represented by formula granules.

Focus on the quality upgrade, secondary development, new indications mining, economic evaluation, clinical value-oriented research on safety and clinical efficacy evaluation of traditional Chinese medicine, and innovative drug development of traditional Chinese medicine, and make efforts in the research on local standards of characteristic Chinese herbal pieces, quality standards that meet the requirements of Pharmacopoeia, effectiveness and safety evaluation, production process improvement, and automation, intelligence and information construction of production and processing.

Focus on Kunming, Yuxi, Chuxiong, Dali, Wenshan, Baoshan, Pu ‘er, Honghe and other cities to develop modern Chinese medicine. On the basis of medicinal animal and plant resources such as Panax notoginseng, Erigeron breviscapus, Gastrodia elata, Paris polyphylla, Periplaneta americana, leech, etc., and taking the development of characteristic ethnic medicines such as Yi medicine and Dai medicine as a breakthrough, we will speed up the cultivation of large varieties of modern Chinese medicine (ethnic medicine) preparations, create a number of brand products, and make Yunnan medicine industry bigger and stronger. Based on classic prescriptions, proven prescriptions and hospital preparations, we will develop innovative Chinese medicine (ethnic medicine) and epidemic prevention preparations covering the whole life cycle of prevention, treatment and rehabilitation for the prevention and treatment of major diseases such as malignant tumors, cardiovascular and cerebrovascular diseases, emerging infectious diseases and AIDS. Guided by clinical value, we will carry out material basic research, safety evaluation of traditional Chinese medicine and clinical efficacy research, and explore the construction of a three-in-one evidence system of "Chinese medicine theory-human experience-clinical trial" for the research and development of new traditional Chinese medicine. Adopt modern biotechnology, advanced pharmaceutical technology and preparation technology to promote the application of biocatalysis and transformation, refining, extraction and separation in the research and development of modern Chinese medicine.

In Kunming, Chuxiong, Wenshan, Zhaotong, Pu ‘er, Baoshan, Lijiang and other major producing areas, the production base of Chinese herbal pieces will be laid out, with the focus on building Chuxiong into a national first-class industrial base of Chinese herbal formula granules. Form more than 10 brand enterprises producing Chinese herbal pieces and local standards for formula granules of more than 100 varieties. Strengthen cooperation with state-level research institutions and well-known domestic enterprises, carry out research on quality standards of traditional Chinese medicine formula granules and upgrade the processing and production technology, and establish a quality standard system, a safety evaluation system and a clinical trial research system for traditional Chinese medicine decoction pieces that meet the requirements of People’s Republic of China (PRC) Pharmacopoeia and international standards. Carry out the equivalent test and production technology research of formula granules, and establish the processing technology and quality evaluation method of traditional Chinese medicine decoction pieces combined with modern science and technology. Develop new modern technologies, equipment and facilities such as extraction, concentration, drying and granulation, apply blockchain traceability technology to improve online quality control, establish a traceability system for processing and production of Chinese herbal pieces, and build a number of intelligent production lines of Chinese herbal pieces with advanced technology and strict quality control.

We will build a research center for ethnic medicine focusing on Yi medicine, Dai medicine and Tibetan medicine, systematically excavate and sort out ethnic medicine documents of Yi, Dai, Tibetan, Naxi, Wa and Hani nationalities, and carry out clinical application of traditional ethnic medicine therapy and its ancillary products and theoretical research on ethnic medicine. Relying on ethnic medicine resources, develop external preparations. Strengthen the research and development and clinical application of preparations in ethnic medicine hospitals, and carry out research and development of new ethnic medicine with clear mechanism, high technology content and reliable curative effect.

Build a characteristic industrial cluster of Sanqi, and build Sanqi into the first brand of traditional Chinese medicine in China. We will build a Sanqi industrial innovation consortium with enterprises as the main body, and gather superior resources inside and outside the province to carry out key technology research and transformation and application of achievements. Develop innovative drugs for prevention, treatment and rehabilitation of cardiovascular and cerebrovascular diseases; Focusing on the large varieties and exclusive varieties of traditional Chinese medicine (ethnic medicine) such as Sanqi series and Dengzhanhua series, we will increase the re-evaluation after listing and the secondary development of "new use of old drugs", and carry out research on the combination of traditional Chinese and western medicine such as "Xuesaitong+aspirin"; Strengthen the biosynthesis and application of panax notoginseng saponins, scutellarin, Paris polyphylla saponins and other extracts; Carry out research on the processing technology and technology of traditional Chinese medicines such as Panax Notoginseng while fresh, and formulate standards for new-type decoction pieces such as formula granules and powder decoction pieces of characteristic varieties such as Panax Notoginseng and Gastrodia elata which meet the standards of People’s Republic of China (PRC) Pharmacopoeia; To study and formulate EU Pharmacopoeia standards for Sanqi formula granules, panax pseudo-ginseng and other products, so as to enhance the international popularity and influence of Sanqi.

Regional cooperation in the research and development of traditional Chinese medicine (ethnic medicine) should be carried out for South Asia and Southeast Asia, international multi-center clinical trials and international registration of traditional Chinese medicine preparations with good clinical effect and clear mechanism of action should be carried out, and a modern standard production system and quality evaluation system of traditional Chinese medicine should be constructed according to international standards.

(3) Health products based on natural extracts.

Continue to strengthen the research on the material basis of effective active ingredients of animals and plants, increase the development and application of extracts, strengthen the development of high-quality health products, and cultivate brand products with market competitiveness and scale effect.

Focus on Kunming, Yuxi, Chuxiong, Pu ‘er, Xishuangbanna, Lijiang, Wenshan and other cities to build health product research and development and production bases, and develop high value-added health products. Focus on health care products and daily chemical products such as Sanqi series, Dendrobium series and microalgae series, and build a number of brand products with sales income exceeding 1 billion yuan. Introduce well-known enterprises at home and abroad, cultivate some leading enterprises, and promote Yunnan’s health products to South Asia and Southeast Asia.

Construction of Yunnan laboratory for extracting characteristic plants. Focusing on plant extraction and scientific and technological innovation in the whole industrial chain of health products, we will systematically carry out basic research, product development and achievement transformation, and build a platform for functional evaluation and inspection of health foods and cosmetics. Using modern biotechnology, we will strengthen the research on the efficacy and application of animal and plant-derived ingredients, cultivate and expand a number of intensive processing backbone enterprises in the main raw material producing areas in view of the needs of food, medicine, health care products, daily chemical products, feed products and other related industries, and promote the extraction and processing of characteristic Chinese herbal medicines such as Panax notoginseng, Periplaneta americana and leech, as well as the raw materials of characteristic health products such as stevia rebaudiana, eucalyptus globulus, marigold, maca, rose, microalgae and aloe, and research and development. Improve the extraction and separation technology and quality level of panax notoginseng saponins, breviscapine, tea polyphenols, coenzyme Q10, paclitaxel, borneol and other extract products, as well as eucalyptus oil, citronella oil, rose oil, rosemary and other essence and fragrance products. Taking notoginseng, gastrodia elata, Dendrobium nobile, Polygonatum sibiricum, Amomum villosum and other medicinal and edible Chinese herbal medicines as raw materials, and special biological resources such as microalgae, Moringa oleifera, walnuts and flowers as raw materials, we have researched and developed various health products such as medicated diet, medicated wine, medicated tea and drinks, as well as a series of health foods, aromatic products and daily necessities with the functions of resisting oxidation, losing weight, enhancing immunity, relieving anxiety, relieving depression, assisting in improving memory and caring skin. Focus on developing and producing a batch of formula foods with strong pertinence and high patient acceptance, which are suitable for surgery, nephrology, oncology, pediatrics and geriatric rehabilitation.

Improve the development level of Panax notoginseng extract. In-depth study of extracts from different parts such as flowers, stems, leaves, roots, etc., and development of Sanqi series health food, special diet products, oral care, medical beauty skin care and other daily necessities in different dosage forms such as tablets, capsules and oral preparations, enriching product structure and expanding application fields; Improve the extraction technology and product quality level of panax notoginseng saponins, polysaccharides and panax notoginseng elements; Study and formulate international standards for the extraction of characteristic raw materials such as Panax notoginseng, and accelerate the internationalization of Panax notoginseng.

2. Rapid development areas

(1) Chemical drugs

Further improve the industrial chain, improve the research and development capabilities of original drugs and generic drugs, and improve the research and development level of high-end preparations.

Focus on Kunming, Chuxiong and other cities to build R&D and production bases for chemical drugs and chemical raw materials, and carry out R&D and industrialization of innovative drugs, improved new drugs, generic drugs and chemical raw materials.

Strengthen the joint development of "intermediates+APIs+chemicals". Improve the production technology of platinum anti-tumor raw materials and steroid hormone raw materials. Encourage enterprises to buy varieties with high clinical value at home and abroad and enterprises with great development potential to enter Yunnan for development. Develop chemical raw materials, auxiliary materials and packaging materials industries in areas with resources and environmental carrying capacity, and develop a number of chemical synthetic drugs with characteristics, potential and competitiveness. Strengthen exchanges and cooperation with Israel, India and other countries in the research and development of generic drugs, and explore the construction of an international cooperation base for the research and development of generic drugs.

Guide key enterprises and scientific research institutions to focus on the development of innovative drugs for major diseases such as malignant tumors, cardiovascular and cerebrovascular diseases, diabetes, mental diseases, viral infections, etc., especially chemical innovative drugs and improved new drugs with new targets and new mechanisms of action. Carry out research and development of high-end preparations, develop new dosage forms with good clinical substitution for varieties and dosage forms that are clinically necessary and have great side effects, and promote the research and development of sustained and controlled release, targeted, transdermal, mucosal and carrier drug delivery systems. Develop Yunnan plant resources, discover and develop new natural chemical drugs. To carry out the imitation of drugs needed for the treatment of major infectious diseases and rare diseases, drugs needed for the disposal of public health emergencies, drugs used by children, and original drugs whose patents are about to expire. Carry out research and development and green production technology innovation in the fields of chemical raw materials and pharmaceutical intermediates; Carry out the construction of the process technology system for the biosynthesis of important pharmaceutical monomer compounds such as panax notoginseng saponins and breviscapine.

(2) Medical devices

Give full play to the advantages of China (Yunnan) Pilot Free Trade Zone (hereinafter referred to as FTZ) and Border Economic Cooperation Zone, speed up the construction of medical device production and trade system for South Asia and Southeast Asia, develop high-tech and high value-added products, and establish an effective linkage mechanism between medical institutions and medical device industry.

We will build medical device industrial parks in Central Yunnan New District, Qujing, Yuxi, Free Trade Zone and Border Economic Cooperation Zone, build medical device R&D and production, inspection and testing, and trade distribution bases for South Asia and Southeast Asia markets, and build the most complete medical device industrial park in Southwest China.

In view of the market demand in South Asia and Southeast Asia, we will introduce domestic and foreign leading or advantageous enterprises in high-end medical devices and biomaterials to build medical device production bases and supporting industrial chains, cultivate high-end medical device enterprises, and promote the development of upstream and downstream industries of medical devices. Support the construction of a production base that meets the quality management standards for medical device production, build a public R&D and production platform for medical devices, build a high-grade medical device life-cycle detection technology service platform based on units with good foundation, and attract enterprises, research institutions, talent teams and technological achievements to Yunnan to carry out the transformation and industrialization of achievements. We will build a number of leading enterprises in the production of in vitro diagnostic reagents, dentures and disposable infusion devices, and promote the development of industries such as medical devices, new biomaterials, high-end pharmaceutical packaging materials and high-quality pharmaceutical excipients.

Develop technologies and products such as gene detection, biological detection chip and in vitro immunodiagnosis, and develop in vitro diagnostic equipment and reagents such as major emerging infectious diseases and tumor diseases; Accelerate the research and development of new biomaterials, and carry out research and development of new biomaterials such as biomedical materials, tissue engineering materials, bio-based materials and medical and health materials; Carry out research and development and production of high-end consumables such as orthopedic instruments, and build a production base of high-end orthopedic consumables in southwest China; Carry out research and development of TCM diagnosis and treatment instruments and equipment, rehabilitation instruments and equipment, and sports therapy equipment with ethnic characteristics; Carry out the development and industrialization of "big data+artificial intelligence+medical care" instruments and equipment, and develop digital and multifunctional mobile monitoring equipment and wearable products, rehabilitation AIDS and optometry-related products.

(3) Veterinary drugs

Further guide enterprises and scientific research institutions, strengthen investment in veterinary drug research and development, enhance the research and development ability of veterinary drugs, and give full play to the advantages of resources to develop innovative products of veterinary drugs.

Strengthen the cooperation between animal medicine enterprises and scientific research institutions inside and outside the province, and develop or introduce a new generation of animal vaccines and innovative products for veterinary medicine. Improve the quality and production capacity of a number of veterinary drugs, such as bovine O-type and A-type foot-and-mouth disease inactivated vaccine, pig O-type foot-and-mouth disease inactivated vaccine, pig double O-type foot-and-mouth disease inactivated vaccine, hog cholera live vaccine (subculture cell source), piglet paratyphoid, Newcastle disease and so on.

Focus on Kunming, Baoshan, Dali and other cities with veterinary drug industry base to actively develop veterinary drug industry. Increase the research and development of livestock and poultry disease prevention vaccines and pet vaccine products such as cattle, sheep, pigs and chickens; Develop a batch of veterinary traditional Chinese medicine preparations with traditional Chinese medicine as raw materials, which can replace antibiotics, carry out veterinary drug imitation research, develop feed drug additives, improve the self-sufficiency rate of veterinary drug production, and actively expand the market in South Asia and Southeast Asia.

(2) To improve quality and accelerate the construction of high-quality raw material bases for Chinese herbal medicines.

Highlight the construction of standardized planting (breeding) bases for Chinese medicinal materials, adhere to the principle of quality first, control the planting scale, innovate the planting mode, promote the original habitat planting, improve the quality of medicinal materials, and scientifically develop large varieties of raw materials such as Panax notoginseng, Erigeron breviscapus, Paris polyphylla, Gastrodia elata and Dendrobium. At the same time, give play to ecological advantages, actively introduce domestic and foreign high value-added medicinal varieties into Yunnan to build a high-quality raw material planting and processing base. Make good use of domestic and foreign resources and markets to build Yunnan into a national raw material base for high-quality natural medicines and health products.

1. Breeding excellent provenances and developing the fine variety industry of Chinese herbal medicines.

In order to promote the sustainable development of Chinese herbal medicine resources, the collection and evaluation of germplasm resources, screening of high-quality provenances, breeding of new varieties and breeding of improved varieties will be carried out around the backbone medicinal materials and rare and endangered Chinese herbal medicines, and the industry of improved varieties of Chinese herbal medicines will be developed. In view of the problems such as source degradation, we will strengthen the domestication and planting of Chinese herbal medicines and the breeding of improved varieties. Strengthen the investigation, collection, identification, preservation and artificial domestication and cultivation techniques of important rare and precious wild raw material germplasm resources such as Fritillaria cirrhosa, Euphorbia Humifusa, Rhizoma Curculiginis, Rhubarb and Dragon’s Blood, and protect the germplasm and genetic resources. In Wenshan, Zhaotong, Chuxiong, Dali, Lijiang, Pu ‘er, Baoshan and other authentic Chinese herbal medicine producing areas and suitable planting (breeding) areas, 50 breeding bases of authentic superior Chinese herbal medicines, 100 guaranteed nursery bases of Chinese herbal medicines and 100 standardized planting (breeding) bases will be upgraded, and a number of Chinese herbal medicine seed and seedling enterprises will be built, with emphasis on cultivating more than 10 high-quality seed and seedling management companies. Relying on the National Nature Reserve, conservation zone, a Chinese herbal medicine, will be built, and more than two protected areas for endangered and rare wild medicinal plants and animals will be planned, and more than 10 wild breeding bases for endangered and rare genuine medicinal materials from Yunnan will be built to provide support for the rapid development of raw materials industry for health products.

2. Strengthen the construction of high-quality raw material bases and build high-quality Chinese herbal medicine planting areas.

Build the "first workshop" of biomedical industry with the concept of green development. According to GAP standards, develop rural areas to revitalize the "one county, one industry" Chinese herbal medicine planting (breeding) industry. Innovate the planting (breeding) mode and vigorously develop "green planting", "ecological planting", "under forest planting" and "imitation of original habitat planting" of Chinese herbal medicines. Encourage domestic and foreign enterprises to build a "pharmaceutical park" in suitable areas of Yunnan, and accelerate the formation of a situation in which leading enterprises lead, bases are standardized and the province develops in an orderly manner. Cultivate a number of well-known enterprises and high-quality raw material varieties, and build a standard library of reference materials for Chinese herbal medicine varieties. Cooperate with neighboring countries to protect and organize traditional medicinal resources in South Asia and Southeast Asia, popularize planting techniques and carry out overseas planting. Strengthen the research and development and application of advanced equipment for planting Chinese herbal medicines, and improve the modernization level of planting (breeding) Chinese herbal medicines. Cultivate original bulk and regional comprehensive primary processing bases of Chinese herbal medicines, and lay out and build regional inspection and testing platforms.

Give full play to the advantages of Yunnan’s ecological environment, national culture and tourism industry, and promote the construction of a number of Chinese herbal medicine health industrial parks (manors) including standardized cultivation (breeding), food culture, health experience, leisure and health preservation, and popular science propaganda, with emphasis on building more than 10 well-known manors.

3. Accelerate the improvement and efficiency of "the hometown of Yunnan medicine" and build the brand of "Yunnan medicine"

Relying on the "Hometown of Yunyao", we will promote the construction of more than 60 standardized, large-scale and standardized planting (breeding) areas of high-quality Chinese herbal medicines, improve the standards of authentic Chinese herbal medicines, study and formulate a number of domestic and international standards for raw materials of health products, expand the scale of green planting and ecological planting of Chinese herbal medicines, standardize the whole process management of raw material planting (breeding), and build a quality monitoring network and traceability system covering the main producing areas of Chinese herbal medicines in the province. Build a green production technology promotion system, a production processing technology system, a quality evaluation system and a traceability system of the whole industry chain, and build a "Top Ten Yunyao" brand. We will carry out basic research on pharmacology, medicalization, efficacy and safety evaluation of Chinese herbal medicines, and develop a number of new food raw materials.

Build Sanqi into a national demonstration variety of Chinese herbal medicine intelligent agriculture. Improve the technology and level of green planting, undergrowth planting and original habitat planting of Panax notoginseng, and improve the supply capacity of high-quality and high-end products. Around the breeding, planting, processing, warehousing and other links of improved varieties of Panax notoginseng, we will build a comprehensive and domestic leading big data platform for intelligent agriculture of Panax notoginseng, and build a digital management and service system for seed and seedling quality evaluation, monitoring and early warning of pests and diseases, intelligent diagnosis, processing of origin, warehousing and logistics, quality inspection, product traceability and so on.

(three) to expand the market and accelerate the improvement of the business system of biomedical products.

Based in Yunnan, facing the whole country, South Asia, Southeast Asia and the Indian Ocean Rim, with the help of internet plus, big data, cloud computing and other modern technical means, we will give full play to the role of free trade zones and border economic cooperation zones, vigorously carry out internal and external cooperation, and build a business system for biomedical products with the focus on market system construction, enterprise management informationization and international business development.

1. Build a regional circulation system

Focusing on free trade zones and border ports, we will lay out and build a number of modern warehousing and logistics centers for biomedical products in all provinces, cities and key counties, cities, districts and border port cities such as Hekou and Ruili, build regional pharmaceutical wholesale and distribution centers, build cold chain logistics, and improve the supply guarantee system for pharmaceutical and health products in Yunnan. High-level construction of Yunnan Chinese herbal medicine trading center, enlarge and strengthen Wenshan Sanqi, Zhaotong Tianma and other regional characteristic Chinese herbal medicine markets, build a futures market for bulk medicinal materials and scarce medicinal materials, and cultivate a regional distributed trading market for fresh medicinal materials. Strengthen the supervision of Chinese herbal medicine market, standardize the access management of Chinese herbal medicine market, and establish a quality inspection, public warehousing and quality traceability system.

2. Promote the development of new logistics formats

Promote the "internet plus" business model, encourage drug circulation enterprises to use the Internet and Internet of Things technology, introduce third-party service organizations such as insurance and logistics, provide extended services such as online pharmacies and drug distribution, and build an information management system covering the whole province’s business circulation. Taking the Chamber of Commerce as the main body, we will jointly build the "Yunyao Information Network" and "Yunyao Database" to build the Yunnan pharmaceutical e-commerce trading platform. Develop the platform economy of "internet plus Traditional Chinese Medicine+Traditional Chinese Medicine+Health Service" and build a new format and new model economy of Chinese medicine industry.

3. Broaden the market channels of Yunyao.

Strengthen cooperation in commercial production, encourage commercial circulation enterprises inside and outside the province to sell Yunnan products, guide commercial circulation enterprises to build production and marketing alliances with raw material planting enterprises and pharmaceutical and health care products production enterprises, and provide market information and sales channels for production enterprises. Develop a number of specialized institutions that exchange and cooperate with domestic and foreign countries, and hold various seminars, exchanges and exhibitions. Encourage business circulation enterprises in the province to become bigger and stronger, and lead production enterprises, especially small and medium-sized enterprises, to expand domestic and foreign markets.

Fourth, the main measures

(1) Vigorously implement accurate investment promotion.

In-depth implementation of the "multiplication" plan of market players, focusing on biotechnology drugs, modern Chinese medicine, chemical pharmaceuticals, health products and other fields, aiming at the top 500 international companies, the top 100 biomedical companies and leading enterprises in the industry, and carrying out accurate investment promotion. Implement the drug marketing license holder system, and introduce innovative achievements holders such as biotechnology drugs, innovative Chinese medicines and chemical medicines to Yunnan to carry out achievements transformation and industrialization. Introduce and develop serum-free cell culture medium, affinity filler medium, ultrafiltration membrane, disposable reaction bag and other upstream and downstream supporting enterprises of biological products represented by vaccines to enter Yunnan for development. Introduce Chinese herbal pieces and health products processing enterprises represented by formula granules into Yunnan to build a raw material base, research and development production base and extend the industrial chain of Chinese herbal medicines. Implement the medical device holder system, give full play to the advantages of free trade zone and border economic cooperation zone, introduce medical device R&D and production enterprises to Yunnan, and build a medical device production and circulation base for South Asia and Southeast Asia. Introduce chemical raw material medicine enterprises into Yunnan for development in areas with resources and environmental carrying capacity. In combination with the introduction of science and technology into Yunnan, we will actively promote the "four landings" of talent teams, scientific and technological enterprises, scientific and technological achievements and innovation platforms, and strengthen the introduction of CRO (contract research and development institutions) and CMO (commissioned production institutions).

(2) Accelerate major projects.

Implement special projects for the development of biomedical industry, organize and implement a number of key projects to support and lead the development of biomedical industry. Relying on leading enterprises and R&D institutions with strong R&D capabilities, we will organize and plan a number of major projects combining "Industry-University-Research" for the development needs of key areas of biomedicine. With the goal of leading enterprises and key brand products becoming bigger and stronger, we will implement a number of quality improvement and efficiency improvement projects through digital and intelligent technological transformation and secondary development. With the goal of building industrial clusters, support key cities, key parks and key enterprises to plan and implement a number of key projects. Encourage the park to plan a number of preliminary projects and implement a number of key projects around infrastructure construction, key industrial bases construction and major scientific research platforms construction, and strengthen tracking management and service guarantee.

(C) focus on cultivating leading enterprises

Implement the cultivation plan of leading enterprises, and comprehensively improve the comprehensive competitiveness of pharmaceutical enterprises. In accordance with the principle of "one thing, one discussion, one enterprise, one policy", we will enlarge and strengthen leading enterprises, cultivate a number of large enterprise groups with international influence, develop and expand a number of key enterprises, support the development of small and medium-sized enterprises, and form enterprise clusters. In the fields of traditional Chinese medicine, biotechnology medicine, chemical medicine and health products, select a group of enterprises with good growth to focus on cultivation. Support enterprises to build raw material bases and production bases around the industrial chain, and improve the level of automation, intelligence and informatization of enterprises. Carry out the listing cultivation of biomedical enterprises, and continue to promote the listing progress of biomedical "golden seed" enterprises. Support enterprises to take capital, technology, brand as the link, through mergers and acquisitions, agreement transfer, joint restructuring, holding shares and other ways to carry out mergers and acquisitions, improve industrial concentration.

(4) Continuously improve the innovation capability.

Focusing on the fields of vaccines, antibody drugs, cell products, modern Chinese medicine, formula granules, chemical drugs, health products, extracts, etc., we will upgrade and build a number of industrial public service platforms and specialized research and development platforms, form a perfect biomedical research and development and technical service chain, and continuously improve the ability of biomedical innovation. Keep a close eye on the commanding heights of industry technology, increase investment in applied basic research, and reserve a number of advanced and applicable technologies and achievements; Adopt the innovative project organization mode of "unveiling the list", aim at the major needs of the industry, break through key technologies, formulate new standards, develop new products and upgrade new processes. With enterprises as the main body, we will build a number of R&D and service platforms such as key laboratories, technology innovation centers, engineering research centers, enterprise technology centers and industrial technology innovation platforms in conjunction with well-known expert teams and scientific research institutions at home and abroad. Promote the construction of the State Key Laboratory of Biomedicine for Non-human Primates, accelerate the construction of Yunnan Laboratory for Extraction of Characteristic Plants, build a new vaccine technology innovation system, and improve the research platforms such as natural drug screening, research on patent medicine, drug safety evaluation (GLP), drug pilot test, drug clinical evaluation platform (GCP) and bioequivalence test. Construction of provincial clinical medical research centers and a number of national clinical medical research sub-centers. Cultivate and introduce several CRO institutions. Promote and build a platform for big data and digital applications around the biomedical industry chain.

(5) Building professional parks with high quality.

With Kunming as the center and Yuxi, Chuxiong, Wenshan, Qujing, Baoshan, Honghe and other cities as the focus, a number of biomedical industry specialized parks covering the whole province will be built. Focus on promoting Kunming National Bio-industrial Base, Yunnan Central Traditional Chinese Medicine Natural Medicine Economic Circle, Yunnan Central Medical Device Industrial Park, Kunming and Yuxi Bio-vaccine R&D and production bases, International Medical Health City, Chuxiong Traditional Chinese Medicine Formula Granule Industrial Base, Wenshan High-tech Industrial Development Zone, Tengyao Industrial Park, Pu ‘er Biomedical Industrial Park, Honghe Biomedical Industrial Cluster, Qujing Malong Medical Device Emergency Industrial Park and other specialized parks and clusters. Based on the evaluation of the carrying capacity of resources and environment and the suitability of land and space development, chemical raw material medicine parks will be developed in Kunming, Chuxiong and other areas that meet the relevant policy requirements of chemical parks. Promote the gathering of projects, funds, talents and other elements in the park, strengthen the construction of public R&D and service platform, industrial incubation, infrastructure, industrial facilities and human resources conditions in the park, and form a regional specialized park integrating research and development, enterprise incubation, manufacturing and logistics distribution. Strengthen cooperation with biomedical industrial parks in Beijing-Tianjin-Hebei, Yangtze River Delta, Pearl River Delta and other regions, attract large domestic and foreign pharmaceutical enterprises, scientific research institutions and teams, CRO institutions and CMO institutions to settle in the parks, promote industrial agglomeration development, vigorously promote the construction of Kunming Great Health Industry Demonstration Zone, and build Kunming and Yuxi into important bases and agglomeration areas for modern biomedical production and research, and Chuxiong, Wenshan and other cities into important bases for modern Chinese medicine industry.

(6) Accelerate the training and introduction of talent teams

Adhere to the problem orientation, deploy the talent chain around the industrial chain and innovation chain, promote all kinds of talent training and introduction programs to the biomedical industry, further strengthen the training and introduction of high-level talents, and introduce high-end management talents, leading scientific research talents, high-level technical talents and innovative teams through multiple channels. Innovate training methods, train all kinds of talents, expand the enrollment scale of biomedical related majors in colleges and universities, and establish specialized talent training bases relying on qualified colleges and universities. Encourage social capital to set up vocational colleges and training institutions, promote school-enterprise cooperation, jointly cultivate and improve the quality of employees, and focus on cultivating a number of scientific and technological research and development talents, enterprise management talents, marketing talents, licensed pharmacists, quality management, testing and consulting service talents. Encourage the park to set up special funds for talents to provide more powerful talent support for the high-quality development of biomedical industry.

(7) Focus on building the brand of Yunyao.

Focus on the superior products such as vaccine series, Sanqi series and Dengzhanhua series, and build the brand of "Yunyao". To build a biological vaccine brand, we should build a specialized vaccine industry park, build a vaccine research and development system, develop innovative vaccine products, and promote the international development of vaccines. Extend the industrial chain of large varieties of Chinese herbal medicines such as Panax notoginseng, Erigeron breviscapus, Paris polyphylla, Dendrobium, Gastrodia elata, cultivate a number of large varieties of Chinese herbal medicines, and create geographical indication protection varieties. Develop ethnic resources of traditional Chinese medicine, develop and expand a number of dual-purpose varieties of traditional Chinese medicine, and promote the formation of a number of brand products such as Chinese herbal pieces, extracts, health foods and functional cosmetics. Implement the promotion action of famous Yunnan medicine products, give play to the leading role of the propaganda department, and form a publicity system with the participation of the government, enterprises and social organizations. Encourage enterprises to carry out various forms of publicity and promotion activities to publicize the advantages, characteristics, achievements, enterprises, brands, products and people of Yunnan’s development of biomedical industry. Build a brand display platform through various trade fairs such as South Expo and Drug Fair.

V. Guarantee conditions

(A) to strengthen organizational leadership

Improve the bio-pharmaceutical industry promotion mechanism, compact work responsibilities, hold regular meetings, analyze industrial development, study industrial policies, deploy promotion work, coordinate and solve key problems in the development of key enterprises and major projects, and promote vertical linkage at the provincial, prefecture and county levels. Further improve the horizontal linkage mechanism of provincial departments, enhance the joint efforts of all departments to promote the development of biomedical industry, and jointly create a good environment to promote the high-quality development of biomedical industry in Yunnan. An expert advisory committee on biomedical industry composed of senior experts in relevant fields inside and outside the province was established to provide strategic advice on the frontier situation, industrial analysis, innovation ability, regional layout, key investment promotion and policy design of Yunnan biomedical industry.

(2) Increase policy support.

Focusing on the research and innovation of new products, achievements transformation, market development and innovative service system construction in the fields of biotechnology drugs, modern Chinese medicine, chemical drugs, medical devices and health products, we will coordinate financial funds, increase investment and refine specific measures to support the innovation and development of biomedical industry. To obtain the national major new drug creation science and technology projects, the national key research and development plan related key projects, according to the law and regulations to give supporting support. Support for key core technology research and key new product development, comprehensive use of open competition, publicity system, horse racing system, directional selection and other ways to organize major innovation projects. Study and formulate policies and measures to support the development of biomedical industry in the free trade zone, and help Yunnan biomedical industry to go out and introduce. Incorporate key projects and major projects involving industrial development into relevant national development plans and strive for national policy support. Actively strive for the inclusion of superior and characteristic drugs in the national basic medical insurance drug list and the national basic drug list. Encourage all localities to adopt the form of "government subsidies, enterprises making profits and people buying" to promote the project of biological vaccines benefiting the people. Deepen the "streamline administration, delegate power, strengthen regulation and improve services" reform and promote the development of industrial agglomeration.

(3) Overall factor guarantee

Through scientific planning, revitalizing stocks, introducing increments and other ways, we will further expand the development space of biomedical industry, and encourage industrial parks to build standardized factories to meet the needs of biomedical R&D and production enterprises on the basis of meeting the requirements of land and space planning and environmental assessment at all levels. Overall balance of land use, electricity consumption, water consumption, sewage and other indicators, scientific planning and layout of biopharmaceutical and innovative drug production bases. Encourage the park in accordance with the principle of intensive land use, overall planning for the protection of the park urgently needed talent introduction, employment units or park employees accommodation construction land. Focus on advantageous fields and varieties, establish key enterprises and project libraries, give preferential policies to key projects, and streamline examination and approval procedures according to laws and regulations.

(D) Expand financing channels

Give full play to the role of provincial financial control group industrial investment fund, and guide key cities and parks to set up biomedical industry investment funds. Strengthen cooperation with various investment companies, banks and other financial institutions, and adopt various ways and mechanisms such as listing financing, equity investment, credit guarantee, risk compensation, bond financing and asset management to promote base construction, product development, achievement transformation and industrialization, enterprise cultivation, brand building and market expansion.

(5) Strengthening digital empowerment

Promote the digitalization of resources, digital industrialization and industrial digitalization in the biomedical field. Apply modern information technologies such as blockchain, big data and artificial intelligence to upgrade the construction of Yunnan biomedical industry big data center, and further improve the production, supply and marketing network of biomedical enterprises, Chinese herbal medicine bases and circulation enterprises covering the whole province. Promote the construction of Yunnan biological resources digital integration center to realize the sharing, trading and calculation of biological resources scientific data. Give play to the role of industrial big data platform, promote data sharing in R&D, production, approval, sales and use, and break down departmental data barriers.

(6) Pay attention to safety and security.

Strengthen the construction of biosafety risk prevention and control and governance system, strengthen the supervision and management of high-risk and medium-risk biotechnology research and development activities, and take effective countermeasures. Give full play to the role of Yunnan Science and Technology Ethics Committee, strengthen overall planning and guidance, strengthen scientific research ethics supervision, standardize all kinds of scientific research activities, strengthen safety training for managers and professional and technical personnel, and ensure the safe and healthy development of biotechnology. We will comprehensively promote the construction of drug safety regulations and standards system, highlight the improvement of supervision efficiency, enhance the ability of drug monitoring and evaluation, audit and inspection, inspection and testing, and intelligent supervision, and realize the mutual promotion of safety supervision and industrial development. Combine the construction of the vanguard of ecological civilization construction, implement the concept of green development, strengthen environmental protection during the development and application of biotechnology products, and ensure ecological security.

(7) Strengthen evaluation and supervision.

Establish a dynamic evaluation mechanism for the implementation of the plan, formulate a task list every year, and regularly supervise the implementation of the plan by the relevant departments of the state, city and province. We will build a supervision and service mechanism for the operation of key enterprises and the construction of major projects, strengthen the operation monitoring of key enterprises and the scheduling, tracking and service of key projects, and promote the early commencement, completion and commissioning of projects.

Attachment: 1. Atlas of Yunnan Biomedical Industry Chain

2. Regional distribution map of "hometown of Yunyao"

3 main indicators, main tasks and key work responsibilities.

Annex 1

Annex 2

Annex 3

　　"Dad, are you ready?" At the beginning of June, a series of copywriting appeared in an advertisement of a medical beauty client to warm up the newly launched "Double Eyelid Festival". This advertisement, which blew up the elevator, also caused widespread controversy because of the encouragement to young medical beauty practitioners implied by the word "Dad".

　　According to the analysis of the 2018 medical beauty industry white paper released by a medical beauty service platform, among every 100 medical beauty consumers in China, there are 19 "post-00", and the momentum of starting medical beauty consumption after 00 is stronger than that after 90. In 2019, the proportion of medical and beauty consumers under the age of 19 in China has reached 15.48%.

　　There are indications that the plastic surgery population is gradually becoming younger. Then, why did "after 00" choose cosmetic surgery early? What is the significance of plastic surgery for them? Is it necessary to have plastic surgery at a young age? Qianjiang evening news reporter conducted an investigation on this.

　　In plastic surgery, minors often appear accompanied by their parents.

　　Engaged in plastic surgery for four years, every winter and summer vacation, Liu Jun, a plastic surgeon in a 3A hospital in Hangzhou, will witness the peak of student gathering. "Almost every month, 60 or 70 students come for cosmetic surgery, accounting for 30%~40%."

　　"Most of them are high school graduates. Because they are about to enter the university, they hope to meet a new life and a new social circle with a better self." In recent years, the demand for medical beauty of high school graduates has been increasing year by year. Liu Jun understands their mentality, but from time to time he will meet several young medical beauticians who are at a loss.

　　"Campus Beauty" Trouble: Am I not very pretty?

　　The girl opposite talked about her various facial defects without thinking. But Liu Jun clearly saw that her face was white and beautiful, her skin was transparent and full, and her facial features were correct. He silently scored 95 points for the girl’s face value.

　　The girl’s name is Fangfang, 15 years old, and she is in Grade Three. She looks in the mirror frequently every day, makes "ugly" comments on herself distorted in her mind countless times, and consults medical beauty everywhere at any cost.

　　Finally, one summer, Fangfang, accompanied by her mother, sat in front of Liu Jun.

　　Liu Jun clearly saw that the girl’s eyes revealed a desire for change — — "My palate is leaning forward. Can I push it back?"

　　After entering the door, Fangfang’s mother just stood by without saying a word, smiling helplessly at Liu Jun.

　　"You are beautiful, there is no need to fix it." Liu Jun interrupted Fangfang’s words and directly denied her biased cognition of herself.

　　"You see, that’s what doctors say." At this time, the mother on the side spoke the first sentence, "I have been persuading for a long time before, but my daughter just doesn’t believe it."

　　In fact, because of her outstanding appearance, Fangfang, the "school flower", has always attracted much attention. But since entering junior high school, I heard someone say that another girl in other classes is more beautiful than herself. Fangfang has been dissatisfied with her appearance since then and started all kinds of strange behaviors.

　　"She is very demanding about her appearance and will constantly exaggerate her shortcomings. It is likely that there is a problem at the psychological level." After rejecting Fangfang’s plastic surgery idea, Liu Jun also made suggestions to the girl’s mother — — Pay attention to children’s psychological state.

　　A boy who visits the plastic surgery department once every three months

　　In the plastic surgery department where Liu Jun is located, Kobayashi, a boy under the age of 20, is also a frequent visitor. "Almost every quarter, he will come once, and the needs are different every time. In addition to me, many doctors also took care of him. "

　　Kobayashi is well-behaved, but he has been particularly concerned about his appearance since high school, and he can constantly find new defects. When he was still in high school, Kobayashi had a mandibular osteotomy in another hospital.

　　"Because of grinding, he has produced new dissatisfaction. Come to me for consultation six months after the operation. " Liu Jun said, "The boy’s mother also took great pains to greet me in advance alone, hoping that I would persuade her son."

　　Liu Jun successfully persuaded Xiaolin to go home, but half a year later, Xiaolin’s mother found the door again. "My son has been good for a while, but now he is entangled again."

　　Although Liu Jun repeatedly persuaded him not to have plastic surgery, Kobayashi always insisted on changing it, but he couldn’t tell the purpose and reason. "Because he paid too much attention to his appearance, he couldn’t concentrate on his studies. He only read until he graduated from high school." Liu Jun guessed that he might be psychologically hit by reasons such as lovelorn love. The best solution is not to find a plastic surgeon like Liu Jun..

　　"Go to the mental health department." In the face of young medical beauticians, Liu Jun often makes such suggestions.

　　Continue to write your own aesthetic mother on your children’s faces.

　　For cosmetic surgery, sometimes the young "post-00" will disagree with their families. "Some children really want to do it, and parents feel that it is unnecessary; There are also some children who have not yet formed aesthetics, but parents impose their own ideas on their children. "

　　"The child is still young, why do you want to cut her double eyelids?" Engaged in medical beauty for 28 years, Zhang Jufang, director of the medical beauty department of Hangzhou First People’s Hospital affiliated to Zhejiang University, met such a small patient for the first time — — Xiao Min, a 13-year-old junior high school girl.

　　"I think her eyes are not good-looking, and girls should have a pair of beautiful big eyes." Xiao Min’s mother said.

　　Zhang Jufang looked at Mandy sitting next to her. She listened to the conversation between adults with a puzzled expression on her face. Xiaomin knows nothing about plastic surgery. She only knows, "Mom asked me to do it, and I will do it."

　　After hearing Xiaomin’s answer, Zhang Jufang refused the operation. "The child didn’t ask for it herself. This operation is meaningless to her. Parents can’t make decisions for their children with their own aesthetics. " She told Xiaomin’s mother that she should decide whether to make facial adjustment after Xiaomin became an adult and formed her own aesthetic view.

　　Liu Jun also met a similar mother and daughter.

　　"As soon as I entered the door, the girl’s mother eagerly told me that her daughter’s eyes were ugly and her nose was ugly … … It doesn’t look good anywhere. "

　　Liu Jun remembers that it was an ordinary-looking high school girl who did have some defects, but the girl herself didn’t care about her appearance. "This mother’s mentality is a bit abnormal and she insists on plastic surgery for her children."

　　Plastic surgeons suggest:

　　Minors should not choose medical beauty.

　　Children’s psychology needs more attention.

　　"One of the most important tasks of plastic surgery clinics is to screen people and understand their plastic surgery purposes clearly." Liu Jun said with emotion, "Some children, we look normal, but they may be distorted in his eyes. In fact, this is a mental disorder and a kind of psychological paranoia. Plastic surgery can’t cure their mental illness. "

　　For young medical beauticians, double eyelid cutting and rhinoplasty are the most popular cosmetic items. According to the data released by a medical beauty service platform, "post-00" has quickly taken over from "post-90" and become a big consumer of medical beauty in double eyelid surgery.

　　Zhang Jufang also disagreed with the "66 Double Eyelid Festival" launched for the medical beauty service platform. "This is a marketing tool that sells double eyelids as products." Zhang Jufang said that double eyelids are an operation, not an assembly line product, and cannot be mass-produced. "It is not advisable to set a double eyelid festival, carry out large-scale promotion and encourage everyone to do double eyelids."

　　"Choosing medical beauty for younger people, from a clinical point of view, we are mainly based on two considerations." Zhang Jufang said, "Some children have congenital defects, such as cleft lip and palate. Performing cosmetic surgery for children can help him build confidence from an early age; Others are to make up for children’s psychological trauma and eliminate inferiority complex. For example, some girls have black hair moles on their faces and are teased by classmates. "

　　For young medical beauty practitioners, Liu Jun suggested, "We should wait until adulthood and establish a mature aesthetic view before considering this matter."

　　Zhang Jufang also believes that "minors should not choose medical beauty, and parents can’t ask their children for plastic surgery for their own needs. College students need to establish correct values and aesthetics, and they can pursue beauty, but not blindly. If you really want plastic surgery, you should also go to a regular hospital or medical beauty institution to communicate directly with doctors and listen to professional advice. "

　　(Except for Zhang Jufang, the characters in the text are all pseudonyms.)

　　　　　　　　 Qianjiang evening news reporter Rong Zhang Chen Xi

　　At the moment when the ambulance siren sounded, in addition to the patients and their families waiting anxiously, there were also emergency medical staff who were eager to get to the scene. In the face of patients seeking help, ambulance drivers play a vital role in fighting for rescue time. In recent days, drivers in the emergency department of Jinshui District General Hospital in Zhengzhou City have become "on fire". In order to shorten the visiting time, more than a dozen drivers spent nearly half a year in their spare time to draw a visiting map covering 1,056 residential buildings in 52 communities. A few days ago, Beijing Youth Daily reporter learned from Director Zhao of the emergency department of Jinshui District General Hospital in Zhengzhou that the use of the visiting map shortened the visiting time by 5 to 10 minutes, and it will be continuously updated and improved according to the construction of residential areas within the visiting scope in the future.

　　45 hand-painted maps bring together 1056 buildings.

　　Recently, the hand-painted map of the driver’s class in the emergency department of Jinshui District General Hospital in Zhengzhou City was "on fire", especially in the emergency circle in Zhengzhou City, the provincial capital, and many people consulted "learning from the scriptures".

　　A few days ago, the reporter of Beiqing Daily contacted Director Zhao, the emergency department of the hospital. According to him, this map of visits began to be planned very early.

　　At the beginning of 2016, after Jinshui District General Hospital moved to its current new location, there were many large-scale residential areas in the core visiting area of the emergency department, and the situation of the residential areas was also complicated, many of which were special. "For example, there are 14 small courtyards irregularly distributed in a large-scale community, and each small courtyard is independent of each other and has different access controls." Director Zhao said that it is sometimes difficult for medical staff who often receive patients to find the building where the patients are located during the day, and it is even more difficult to find the road at night. "Later, we thought, can we mark the roads in each community for the convenience of all drivers?" Later, more and more communities needed to be marked, and everyone simply collected the details of more than 50 communities.

　　Shi Shuai, the driver of the emergency department, once studied painting. He was mainly responsible for sketching in the process of making the map of home visits, and the rest of the drivers were responsible for on-site exploration of the roads and entrances of the community and marking them in detail on the map.

　　It starts from Lianhuo Expressway in the north, the North Third Ring Road in the south, Jinbei Road in the west and Wenhua Road in the east. In the core visiting area of Jinshui District General Hospital in Zhengzhou City, the masters of the driver class spent half a year familiarizing themselves with the specific conditions of more than 50 residential areas, and then they were drawn on 45 hand-drawn residential area plans by Shi Shuai, the driver and first aid worker.

　　The average consultation time is shortened by 5 to 10 minutes.

　　"The traffic conditions of roads in the community, including traffic lanes and pedestrian walkways, as well as the traffic conditions of each door in the community, especially those with fire doors and fire exits, are often the most convenient first-aid passages." Shi Shuai said that in addition to marking the location number of each building in the community, it is also necessary to clearly mark the orientation position of each unit. "Especially in the case of poor sight at night, it is convenient for medical staff to quickly find the patient’s home."

　　The reporter of Beiqing Daily noticed that the contact information of the property was still left on the floor plan of many communities. Shi Shuai explained that in some high-end residential areas, it is difficult for ambulances to enter because of the separation of people and vehicles and the low underground garage door. "Everyone wrote down the switchboard of the property according to their experience. Once you receive the mission of visiting critically ill patients in the community, call the property switchboard at the first time, ask the security guard to open the ground fire door in advance, and lead the ambulance to the corresponding building to treat the patients in the most timely manner. "

　　The drawing of the home visit map directly shortens the time of receiving treatment in the emergency department. What impressed Shi Shuai was that at the end of 2017, he and his colleagues had just finished drawing the area of nearby Provence Community, and the emergency department received a call for help. Ms. Liu of Provence VI had a heart attack, and after calling 120 for help, the medical visiting team quickly determined the location according to the "visiting map". With the cooperation of the property personnel, Ms. Liu was quickly found and sent to the hospital, and finally Ms. Liu was successfully rescued.

　　"Now the 45 maps we have drawn basically cover all the reception areas of the hospital. Once we receive a phone call to confirm the location, we will find the corresponding location on the map and soon find the best way to get through. The reception time is shortened by 5 to 10 minutes on average." Shi Shuai introduced.

　　The map specially marks the location of special people.

　　In addition, Shi Shuai said that he and his colleagues also specially marked the location of special people in the community on the map. "For example, there are many elderly residents in some communities. The buildings No.19 and No.20 in a certain community are low-rent houses, and all of them live in low-income households, even the disabled and widowed elderly. In response to their help, our doctors, nurses and drivers must try their best to give special care. "

　　Master Xia worked in the emergency department of Jinshui District General Hospital for many years. Once he received a 120 call for help, he learned that an old man in his 90 s suddenly became incontinent, and his son in his 70 s took care of the old man. Because the elevator is too small, it can only be carried by people. "Master Xia picked up the old man without saying anything and sent him to the ambulance." Shi Shuai said that no matter which driver in the driver’s class encounters such a situation, he will fight for more rescue time for the patient like Master Xia.

　　Talking about the original intention of hand-painted maps, Shi Shuai said that in fact, the original intention of hand-painted maps is to compress time against time and get patients treated as soon as possible. "As long as you work in the emergency department for one day, everyone can feel that time is life."

　　"After our hand-drawn map is made, the driver class will have one copy, which greatly improves the efficiency of home visits." Director Zhao said that because of the rapid construction of Zhengzhou North District, this hand-drawn map will be further improved with the surrounding environment and the construction of residential areas.

　　Text/reporter Zhang Xiangmei