Turn waste into food! Efficient synthesis of starch and protein from corn stalk.

The joint team used the multi-enzyme molecular system containing cellulose degrading enzyme and starch synthase in vitro to biotransform with Saccharomyces cerevisiae, which can hydrolyze cellulose in corn stalk with high efficiency to synthesize artificial starch, and at the same time produce microbial protein by low-cost fermentation under aerobic conditions.
The rapid growth of global population and climate change will make mankind face great challenges to food security. Using synthetic biotechnology to efficiently convert agricultural waste resources into artificial food is one of the important ways to alleviate the food crisis and realize the sustainable development of agriculture.
Recently, Tianjin Institute of Industrial Biotechnology of China Academy of Sciences, together with Institute of Biotechnology of Chinese Academy of Agricultural Sciences, developed a new technology to efficiently synthesize artificial starch and single cell protein from corn stalk, which further reduced the production cost of artificial starch and provided a new way for grain production. Related research papers were published online in Science Bulletin (English version).
Producing starch from lignocellulose is expected to alleviate the food crisis.
The world produces about 200 billion tons of lignocellulose every year. Because each ton of lignocellulose contains about 40% cellulose, it produces about 80 billion tons of cellulose every year.
"Human beings can digest dextran linked by α-1,4-glycosidic bonds, that is, starch, but due to the lack of cellulose hydrolase, they cannot digest dextran linked by β-1,4-glycosidic bonds, such as cellulose, from lignocellulose. If the glucan composed of β-1,4-glycosidic linkage can be converted into the glucan composed of α-1,4-glycosidic linkage through enzymatic reaction, that is, using non-food biomass to produce starch is expected to alleviate the food crisis, which will be a great benefit for human beings. " Ma Yanhe, one of the authors of the paper and a researcher at Tianjin Institute of Industrial Biotechnology of China Academy of Sciences, said.
Developing multi-enzyme molecular system in vitro to improve the production efficiency of artificial food
In this study, in vitro multi-enzyme molecular system containing cellulose degrading enzyme and starch synthase was used for biotransformation with Saccharomyces cerevisiae. Cellulose in corn stalk could be hydrolyzed with high efficiency to synthesize artificial starch, and microbial protein could be produced by low-cost fermentation under aerobic conditions.
"In this study, we first created a low-cost efficient cellulose degradation and cellobiose production technology to remove β -glucosidase from commercial cellulase, effectively removed β -glucosidase from cellulase mixture, and used cellulose-enzyme-yeast complex to reduce the feedback inhibition of cellulose hydrolysate and improve the hydrolysis ability of cellulase." Zhang Wei, one of the authors of the paper and a researcher at the Institute of Biotechnology of the Chinese Academy of Agricultural Sciences, said.
Zhang Yiheng, a researcher at Tianjin Institute of Industrial Biotechnology, China Academy of Sciences, said: "Traditional biological manufacturing relies on living organisms such as microorganisms, plants and animals, but a lot of energy and sugar resources are used for self-reproduction, replication and life maintenance of organisms unrelated to biological manufacturing, which restricts the improvement of manufacturing efficiency. In vitro multi-enzyme molecular system is a new tool of synthetic biology, which completely avoids the above unnecessary waste and greatly improves the energy utilization rate, just as machinery replaces cattle in agricultural production, making it possible to achieve high production efficiency of artificial food. "
"One of the important technological breakthroughs in this research is the preparation of intracellular recombinant enzyme at low cost. The team transformed the recombinant enzyme expression strain, used cheap inorganic nitrogen source and glucose culture medium to carry out microbial culture at ultra-high density, and reduced the production cost of key recombinant enzymes to near the lowest theoretical value, achieving the production cost per kilogram of recombinant enzyme (dry weight) of only 250 yuan, which reduced the enzyme cost by about 1 million times compared with laboratory shake flask fermentation and conventional enzyme purification technology; The second breakthrough is that on the basis of using the existing low-cost cellulase, after removing β -glucosidase by new technology, cellulose can be hydrolyzed efficiently, stably and controllably, and its cost is nearly 1 million times lower than that of expensive purified cellulase. " Zhang Yiheng said.
This new technology has opened up a new way for the production of artificial grain, achieved the goal of securing China’s rice bowl with cutting-edge new technology, and realized "storing grain in technology, storing grain in mountains and storing grain in forests", which is expected to solve the economic dilemma of grain storage and consolidate the foundation of food security in China. (Ma Aiping)
Source: Science and Technology Daily
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Wang Xuedong: In Xizang, fighting the plateau with precision medicine.

Cctv news(Reporter/Chen Shiwen correspondent/Han Dongye): How long is a year? The 3-year-old Dawa went to school and gradually forgot her father’s appearance; Erwa, who is half a year old, babbles and learns to call her father for the wedding photos. And he, tanned by the light of the Qinghai-Tibet Plateau, lost a circle, but succeeded in expanding the year to be thick and full. He is Wang Xuedong, deputy chief physician of the Department of Hepatobiliary and Pancreatic Surgery, Chang Gung Memorial Hospital, Tsinghua, Tsinghua University, and the first supporting doctor in the general surgery department of Lhasa People’s Hospital, Xizang in recent five years. In the summer of 2020, he came to Lhasa as a Tibetan aid doctor and began his dream trip to spread the concept and technology of precision surgery on the Qinghai-Tibet Plateau.

Wang Xuedong is in Lhasa, Xizang.

"I made this decision without thinking too much."

When careful Wang Xuedong was still working in Beijing, he found that there were many patients from Xizang in the hospital, but unfortunately some diseases dragged on late. This made him very emotional. If there is a way to find it early and treat it early, the treatment effect will be better.

Wang Xuedong’s teacher, Academician Dong Jiahong of China Academy of Engineering, is not only the founder and advocate of the concept of precision surgery, but also goes to Xizang, Qinghai, Xinjiang and other remote areas for screening, free clinic and operation of liver hydatid disease every year. Probably because of what I heard, the desire to participate in the treatment of local patients took root in Wang Xuedong’s heart.

Beijing’s "group-based" medical aid to Tibet began after the Sixth Central Xizang Work Forum in 2015. Due to the development needs of different departments in local hospitals in Xizang, and the local general surgery has a certain technical foundation, five years later, in 2020, general surgery finally got a chance to help. It took less than a week from the decision to sign up for Tibet aid to the departure. Wang Xuedong’s "efficiency" is amazing for a one-year task that spans more than half of China and is thousands of meters above sea level.

The outbreak of the epidemic in 2020 made all the work start relatively late. In late July, Wang Xuedong received a notice to leave at the end of that month just after signing up. Because the epidemic is severe, everyone needs unified management. "The day after tomorrow, about two days later."

As soon as Wang Xuedong got home, he quickly packed his things. He and his wife counted the time and left in less than 48 hours. The combined age of the two children is less than four years old, which is the time when the family needs manpower most. Wang Xuedong recalled that his wife gave him unlimited support and took the initiative to provoke the burden of the family, so that he had no worries about this "journey".

The mission of aiding Tibet is Lhasa People’s Hospital, which is more than 3,700 meters above sea level. Not only is there no oxygen, but the air pressure is very low and the climate is extremely dry. Even so, Wang Xuedong boarded the flight to Xizang without much thought. Wang Xuedong remembers, "From getting off the plane to walking out of the airport, I took two breaks with heavy luggage." When he is physically active or talking too much, he will easily gasp and feel flustered in severe cases. Although he is getting used to it now, Wang Xuedong will obviously feel more tired after each operation.

The picture shows Dong Jiahong (third from left) and Wang Xuedong (first from right) teaching rounds in Lhasa People’s Hospital.

The vacuum-packed food he brought from Beijing is all bulging, because the air pressure here is only half that of the plain area. Because the air pressure is too low, the human body becomes difficult to sleep at night. If you forget to take sleeping pills at night, you will naturally wake up once every hour. The unit distributed more than one humidifier, but when you get up in the morning, blood clots often condense in your nose. For Wang Xuedong, these small difficulties are insignificant in the face of saving lives.

After the first two weeks of training, department investigation and stubble handover, Wang Xuedong learned that the local general surgery technology can cover most common and frequently-occurring diseases, such as cholecystitis, appendicitis and simple treatment of liver hydatid disease. However, compared with large and medium-sized hospitals in China, there is still much room for improvement in treatment concept, surgical techniques, including clinical research and department system. In addition, many operations can’t be completed in local hospitals and need to be referred for treatment.

What I saw and heard in Lhasa made Wang Xuedong set his first goal: to improve the business he had carried out; Patients to be transferred, stay.

The concept of precision surgery: know yourself and yourself, and win every battle.

The picture shows Dr. Wang Xuedong (first from left) performing the first 4k laparoscopic choledocholithiasis operation in Xizang.

In August, 2020, Wang Xuedong led the team to carry out the first 4K laparoscopic cholecystectomy and choledocholithotomy through cystic duct in Xizang Autonomous Region. The door of minimally invasive surgery is opened here, and a variety of difficult minimally invasive operations such as large-scale liver resection, radical gastrectomy, radical colorectal cancer resection, pancreaticoduodenectomy, and endoscopic resection of gastric stromal tumors are gradually developed. Today, they have made 9 records of the first operation in Xizang Autonomous Region and 3 records of the first operation in Lhasa People’s Hospital.

In October 2020, a 4-year-old child, Solang Gray, came to the general surgery department of Lhasa People’s Hospital. Three months ago, Solang had undergone a major thoracotomy for pulmonary echinococcosis, and at that time, his liver was also diagnosed with echinococcosis. Due to many factors such as local natural environment, sanitary conditions and cultural customs, this disease is relatively high in the local area, and it is a parasitic disease that is zoonotic.

Three-dimensional surgical planning and virtual surgical resection were performed for four-year-old children before minimally invasive right hemihepatectomy

According to the abdominal image at that time, the liver hydatid in Xiao Suolang had invaded most of the right liver, and two lesions, with diameters of 11 cm and 8 cm respectively, were next to important pipelines such as hepatic portal and middle hepatic vein. When I came to the hospital again and heard that I had to have surgery again, Xiao Solang was very resistant and afraid of postoperative pain and scars.

According to Xiao Solang’s situation, open resection is simpler and safer. Although laparoscopic resection of the lesion is minimally invasive, it is difficult: the abdominal space in children is small and the lesion is huge, and it is difficult to dissect and expose the hepatic portal under endoscope, and the lesion is close to the middle hepatic vein. Accurate preoperative evaluation is needed for accurate laparoscopic resection.

Wang Xuedong said that in traditional surgery, exploration is the main surgical step, that is, after the operation, the specific surgical method is decided according to the situation found during the operation. However, this kind of "exploration" is faced with great uncertainty, and there are often many temporary problems to be solved during the operation, and it is difficult to do the preoperative preparation.

The concept of "precision surgery" actually runs through and is embodied in the whole process before and after the operation, including not only precise surgical operation, but also accurate preoperative evaluation and precise surgical planning, that is, minimizing the uncertainty of traditional surgery and achieving "know yourself and know yourself, and win every battle". Sufficient surgical information should be made clear before operation, so as to strike a balance between maximizing lesion removal, maximizing organ protection and minimizing trauma. The preoperative preparation is done, and the operation is basically half successful.

In order to eradicate liver hydatid disease, reduce trauma and shorten recovery time, Wang Xuedong contacted many parties, and finally coordinated the "three-dimensional quantitative surgery planning system" for the department, and established the "precision surgery cooperation cloud center". By importing the preoperative image data of Sauron Jr., a three-dimensional visualization model was established, and several simulated hepatectomies were carried out in the three-dimensional planning system to predict the problems in the operation and make corresponding plans.

In the end, Wang Xuedong successfully performed laparoscopic right hemihepatectomy for Xiao Suolang, and the bleeding amount was less than 200ml. Xiao Suolang was able to get out of bed on the first day after operation. The introduction of this technology has not only changed the fate of patients with liver hydatid disease and liver cancer, but also changed the status quo of surgeons in Lhasa People’s Hospital. The concept of "precision surgery" is deeply rooted in people’s hearts through continuous practice.

One-day aid to Tibet, lifelong aid to Tibet

During a ward round, Wang Xuedong learned that a child had been hospitalized for more than two weeks due to incision infection after appendectomy. When asked, he realized that it was due to the long-standing cooperation problem that emergency operations such as cholecystectomy and appendectomy were still performed by laparotomy at night and weekend. This incident woke up Wang Xuedong, who was immersed in developing surgical skills. Some old ideas and systems are becoming the "shackles" for the development of the department.

"It is not possible to fight alone, but to operate in an integrated manner; It is not enough to rely solely on technological innovation, but to reform the department and talent system; It is not enough to do clinical work alone, and clinical research should be carried out. " For such a "big move", Wang Xuedong has a clear thinking. Compared with the promotion of pure technology, the improvement of the system will have greater influence and benefit on patients and departments.

Enter the temple for a free clinic for monks in Gandan Temple.

After repeated communication, coordination and resolution at the meeting, in December 2020, with the cooperation of anesthesiology department, operating room and other departments, Wang Xuedong led the general surgery to successfully carry out emergency laparoscopic surgery at night and on weekends. By June, 2021, more than 100 cases of emergency minimally invasive cholecystectomy and appendectomy were completed in general surgery, and no incision infection was found. The average length of hospital stay decreased from 9 days to 2.7 days, and the bed turnover rate increased by nearly 60%.

Wang Xuedong realized that when technology and system are available, the concrete implementation of things can not be separated from the ideas in the mind. He thought, "If I return to Beijing, local doctors can continue to do and develop according to this concept, as long as they follow this process. Only by practicing the whole process can we have a deeper understanding and experience of the concept. " After half a year’s technical teaching, Wang Xuedong no longer needs the chief surgeon, and his disciples can gradually carry out some operations independently, such as right hemihepatectomy, fluorescent laparoscopic gallbladder/bile duct surgery, percutaneous transhepatic biliary drainage (PTBD) and transcatheter arterial chemoembolization (TACE).

Wang Xuedong established a general hospital system in general surgery, breaking the current situation that there is no general hospital in the department for 20 years, and coordinating the work of general patient admission, hospital consultation, weekend and night emergency surgery, so as to cultivate reserve talents; He divided sub-professional groups in detail, including hepatobiliary, gastrointestinal, anorectal, hernia and abdominal wall, blood vessels, intervention, etc., breaking the traditional "big pot" pattern; Five doctors were sent abroad for further study, and a sub-professional group was arranged every week to explain the clinical guide … …

In order to improve the ability of clinical research, Wang Xuedong applied for the subjects in the hospital and the autonomous region respectively for the common diseases of hepatic echinococcosis and cholecystolithiasis in Xizang, and led the department team and disciples to conduct clinical research. At present, the data of SCI papers are being collected, and Tsinghua University Publishing House has also completed the project of books on common diseases of general surgery with plateau characteristics.

Wang Xuedong said, "Even if I end my support and leave Xizang, these will continue to operate. This should be what we often say to build a medical team that we can’t take away."

After a while, Wang Xuedong’s aid to Tibet this year will come to an end. He can’t forget the experience of giving free clinics to local people in temples and villages. In those remote mountainous areas with an altitude of more than 5,000 meters, the medical needs are still urgent, and the awareness of health check-up needs to be strengthened.

After Wang Xuedong and his team came here, they found some new problems. For example, there are still many differences between the disease spectrum and disease stages here and the mainland. There are many topics worthy of further study, such as comparing the diagnosis and treatment of some diseases in different natural environments and health habits between the mainland and the plateau, and whether it is necessary to make some regional and differential treatments. It is helpful for both sides to study these.

Back in Beijing, Wang Xuedong’s aid to Tibet will not stop. The "hospital-contracted" aid work and project cooperation for the Qinghai-Tibet Plateau are all under orderly preparation. One-day aid to Tibet, lifelong aid to Tibet. As he said: "As long as it is needed here, whether I am in Xizang or Beijing, I will go all out."

The central bank announced that it would cut interest rates from today.

[Dahe Finance Cube News]On September 27th, the central bank announced that in order to strengthen the countercyclical adjustment of monetary policy and support the stable economic growth, the operating interest rate of 7-day reverse repurchase in the open market will be adjusted from the previous 1.70% to 1.50%. The operating rates of 14-day reverse repurchase and temporary positive and negative repurchase in the open market will continue to be determined by adding and subtracting points on the operating rate of 7-day reverse repurchase in the open market, and the range of adding and subtracting points will remain unchanged.

Belarus "sends" refugees to the EU border? Kegong: The situation on the border between Poland and Belarus is "shocking"

[Global Times reporter Yu Yang Ren Zhong Liu Yupeng] The border area between Poland and Belarus has become the latest front line for the western camp to compete with the Russian-Belarusian alliance. It is reported that in the past few days, the Belarusian army "escorted" nearly 1,000 refugees to the border of Bai Bo every day; As of the 9th, Turkish Airlines still sent refugees from Iraq, Syria and Afghanistan from Istanbul to Minsk, the capital of Belarus, twice a day. The Polish Defense Minister warned on the 8th that tens of thousands of Polish soldiers are ready to "defend the border". On the 9th, the European Commission accused Belarus of luring immigrants with "inhuman and gangster ways" and "false promises of easy entry into the EU". Belarus insists that the immigrants arrived there legally, and it was only transferred "as a hospitable country". "At that time, more than 2,000 Polish soldiers invaded Iraq for’ establishing democracy’. Why doesn’t Poland accept as many’ grateful Iraqis’ as possible today? " Russian Foreign Ministry spokesman Zacharova said this on the 8th.
Thousands of refugees from the Middle East and North Africa have recently tried to enter Poland from Belarus. The picture shows the Polish military police (behind the barbed wire) guarding the border between Poland and Belarus on November 8.
Polish border guards use tear gas.
The head of the Polish Border Service confirmed that a wave of illegal immigrants who tried to enter Poland from the Belarusian border had been stopped on the evening of the 8th local time, and these immigrants were still camped on the Belarusian side of the Bai Bo border on the 9th. The Polish Border Service announced that customs clearance at Kuznica port on the border of Bai Bo was suspended from 7: 00 on November 9.
According to the British "Guardian" report, the video released by Belarusian media on the 8th showed that white armed border police wearing combat uniforms led a group of people, including families with children, to a forest on the border of Bai Bo in an organized way along the border road. Critics believe that this is Lukashenko’s "dramatic attempt" to put pressure on Poland. Subsequent video footage showed that Polish border police used tear gas to drive people away because many people tried to cross the border through barbed wire. Polish helicopters hovered over the scene, and some immigrants shouted "Germany!" This is their final destination.
On the 9th, Polish President Duda accused Belarus of attacking the border between Poland and the European Union "in an unprecedented way". "This is an act of aggression that must be resisted to fulfill our obligations as a member of the European Union". Polish Defense Minister Bovashchak tweeted on the 8 th: "More than 12,000 soldiers have been on standby at the border." Polish Prime Minister Morawiecki warned Belarus on Facebook on the 8th: "The border of the Republic of Poland is not just a line on the map. It is sacred-in order to protect it, generations of Polish people have shed blood. "
The border between Bai Bo is more than 400 kilometers long, and the two countries also share the last virgin forest in Europe-Biawovieza forest, which makes it more difficult to prevent refugees from entering the EU. Poland’s Election newspaper called on NATO to "provide additional military assistance to Poland" to deal with the crisis.
On the 9th, White President’s Press Office said that Lukashenko and Russian President Vladimir Putin had a phone conversation to discuss Poland’s "severe actions against peaceful people". On the 9th, the Belarusian State Border Committee voiced through Facebook, "Foreigners near the Polish border expressed their intention to enter Polish territory and exercise their right to apply for refugee status from the EU. All these people, including women and children, do not pose a security threat and have no aggressive behavior. ""We do not rule out provocative actions by the Polish side to prove that the use of force and special means against refugees is justified. " On the 9th, the Belarusian Ministry of Defence also accused Poland of sending troops to the border with Bai Bo in violation of the agreement between the two countries.
Poland’s forced expulsion of border migrants has been criticized by human rights organizations. The border environment of Bai Bo is harsh, especially the temperature has dropped below zero degrees Celsius recently. CNN9 said on the 9th that the Polish government admitted that at least seven refugees died after crossing into Poland.
Russian Presidential Press Secretary peskov said on the 9 th that the situation on the border between Poland and Belarus is "shocking". "In this case, the most important thing is human life and health … We are paying close attention to this matter."
The "refugee flight" flew from the Middle East to Minsk.
According to the Guardian, this deadly crisis has escalated. According to Polish statistics, more than 30,000 refugees have tried to enter Belarus since August, and there were about 17,000 in October alone. Polish border guards told Reuters on the 9th that about 800 people camped at the place where they tried to cross the border the night before. Together with illegal immigrants stranded in the nearby forest, it is estimated that there are more than 4,000 people at present. According to the Russian News Agency reported on the 9th, the Lithuanian government is preparing for the possibility of similar "invasion", and the Ministry of the Interior proposes to declare a "state of emergency".
The EU accused Belarus of transporting illegal immigrants as a means to "retaliate against EU sanctions". Ursula von der Leyen, president of the European Commission, said in a statement on the 8th that the EU should now extend the sanctions against the Belarusian regime: "It is unacceptable to use immigrants for political purposes." She also promised to provide more support to countries such as Poland, Lithuania and Latvia to deal with the influx of refugees on the border, and said that the EU would explore "how to sanction, including blacklisting third-country airlines engaged in human trafficking".
According to the website of "EU Observer" and the BBC)9 reported on the 9th, Turkish Airlines and Dubai Airlines may be blacklisted by the EU for transporting immigrants to Belarus, and airlines from Syria, Iran and Qatar are also under consideration. According to the data of Minsk Airport on the 9th, Turkish Airlines still sends immigrants from Istanbul to Minsk twice a day. EU High Representative for Foreign Affairs and Security Policy borrell will visit the main countries of origin and transit of refugees in the next few days, including Armenia, Egypt, Iraq, Jordan and Lebanon, and call on them to take actions to prevent illegal immigrants from "falling into the trap set by Belarusian authorities".
The German newspaper Le Monde quoted German intelligence sources as saying that about 800 to 1,000 immigrants, mainly from the Middle East, arrive in Belarus every day. After their arrival, the Belarusian regime helped them to enter the European Union. The latest flight schedule of Minsk Airport shows that until March next year, the airport plans to have about 40 flights from Middle Eastern countries every week. Moreover, in the near future, the country will open five other civil airports to provide services for the "refugee route", among which Grodno Airport is only 20 kilometers away from Poland.
American citizens apply for asylum in Belarus.
On the 8th, the State Council spokeswoman Price expressed concern about "disturbing images and reports from the border of Bai Bo" and called on Minsk regime to "immediately stop planning and forcing illegal immigrants to cross the border into the EU". He also said that the United States "strongly condemns the political exploitation and coercion of the vulnerable groups by the Lukashenko regime, and the ruthless and inhumane facilitation of illegal immigrants to cross the border".
However, to the embarrassment of the U.S. government, American citizens actually applied for political asylum in Belarus. According to a report by Belarusian TV on the 8th, American Neumann, who is wanted by the Federal Bureau of Investigation (FBI) for attacking the police in the riots on Capitol Hill on January 6th this year, is applying for asylum in Belarus. After the FBI began to arrest him, he hid in Xizang in the United States, then fled to Europe, and then arrived in Ukraine in March this year, where he was still being hunted. In August this year, he was arrested by the Belarusian border forces while crossing the Ukrainian border. White TV said Neumann was "an ordinary American whose shop was burned down by’ black life is life’ activists" and "he lost everything and is being persecuted by the United States".
"The immigration crisis on the border of Bai Bo has rapidly evolved into an international event." The website of "EU Observer" said that the Polish special envoy to the EU will hold crisis talks with the special envoys of 26 other EU countries in Brussels on the 9th. NATO has a treaty obligation to protect Polish territory and has a multinational force in Poland. On the 9th, Germany urged the EU to "take action" to help Poland ensure border security. The German Bild newspaper described the incident as a "joint attack on the EU" by Russian President Vladimir Putin, Turkish President Erdogan and Belarusian President Lukashenko. German Chancellor Angela Merkel’s spokesperson Sebert told the Associated Press on the 8 th: "The Belarusian regime is acting as a human trafficker."
The Hill said that Belarus is one of Russia’s main allies, and the title of the white TV program about Neumann is "Goodbye America", in order to boost the anti-American propaganda supported by Russia.
Russian Foreign Minister Sergei Lavrov commented on the border crisis in Bai Bo on the 9th, saying, "Don’t forget where the legs grow". He said: "The policy towards the Middle East and North Africa that the West, including NATO and the European Union, has been pursuing for many years, that is, trying to impose a’ better life’ on them in the Western way. This is where the legs grow. I believe that to solve these problems, we must fully respect the principles of international humanitarianism. "
Reporting/feedback

Who will Changan’s new wet dual clutch gearbox replace?

  [Gearbox Technology] Recently, we learned thAT the car is about to launch a brand-new wet type, which will be mounted on the upcoming brand-new model CS85. This is the fourth model of Changan Automobile on five SUV models, and the strategy of using dual-clutch gearboxes at low levels and AT automatic gearboxes at high levels will probably change. So what role will this brand-new dual-clutch gearbox play in Changan’s SUV product line?

Home of the car

  It is reported that this gearbox is the first self-developed dual-clutch gearbox of Changan Automobile. We still don’t know the specific gear number and internal structure, but as one of the core components of the dual gearbox, the dual-clutch module adopts the products provided by Borg Warner.

Home of the car

Home of the car

-Future layout of Changan SUV models

  As another brand-new SUV model of Changan Automobile, the positioning of CS85 should be between CS75 and CS95, and it is expected to be one. Since then, Changan’s SUV series will cover all mainstream SUV markets from small to medium and large. So after being mounted on CS85, which models will this brand-new wet dual-clutch gearbox be mounted on?

Home of the car

  AT present, in the product line of Changan SUV, CS75 and CS95 both use 6-speed AT automatic gearbox, and CS35 uses 4-speed AT automatic gearbox, but it is reported that the modified CS35 will be replaced with 6-speed AT automatic gearbox, while the smallest CS15 uses 5-speed dual-clutch gearbox.

The gearbox currently carried by Changan SUV models. car make and model Automatic gearbox name CS15 5DCT CS35 4AT CS75 6AT CS95 6AT

  Since Changan has a 5-speed dual-clutch gearbox, we guess that this brand-new dual-clutch gearbox of Changan should be a 6-speed or 7-speed wet dual-clutch gearbox. After being installed on CS85, it will be used on CS95 and CS75 one after another to replace the current 6-speed AT automatic gearbox.

Editor’s comment:

  AT present, in the domestic market, the position of dual-clutch gearbox is still slightly higher than that of AT automatic gearbox. When it comes to dual-clutch, it is generally believed that it will be superior to AT automatic gearbox in the same gear in technology. This has led to the continuous efforts of China brand in the field of dual-clutch gearbox in recent years. Some of them have independently developed and some have introduced joint ventures. What will happen to Changan Automobile’s first independent dual-clutch gearbox? Let’s wait and see. (Text/Figure car home Miao Shuai)

Lanzhou New District: Out of the Road of Green Development of Industrial Iterative Upgrading

Gansu, China Network October 18 th(Our reporter Song Fangke, Ren Lei, Yang Yanru) On October 18th, a network interview group from China on the mother’s river went into the chemical industry park in Lanzhou New District to visit the "liquid sunshine" ecological energy project and see the green industry leading the future energy development trend.
Lanzhou New District is the first in the northwest and the fifth national new district in China. Under the correct leadership of the Gansu Provincial Party Committee and the provincial government, and with the care and support of the Lanzhou Municipal Party Committee and the municipal government, Lanzhou New District closely follows the strategic positioning given to the new district by the state as "an important national industrial base and a demonstration area for undertaking industrial transfer", and makes a scientific decision according to the situation. In early 2018, it was decided to develop a green chemical industry in Lanzhou New District. Nowadays, the green industry in Lanzhou New District has gradually become a scale, leading the development of green energy industry.
The Outline of the Yellow River Basin Ecological Protection and High-quality Development Plan issued by the Central Committee of the Communist Party of China and the State Council mentioned supporting Lanzhou New District, Xixian New Area and other national-level new districts and Zhengzhou Airport Economic Comprehensive Experimental Zone to become refined and strong leading industries. Give full play to the role of Gansu Lanbai Economic Zone, Ningxia Yinchuan-Shizuishan, Shanxi-Shaanxi-Henan Yellow River Golden Triangle to undertake industrial transfer demonstration zones and improve the ability to undertake industrial transfer at home and abroad.
Lanzhou New District focuses on developing green chemical industry, and constantly improves its capacity to undertake industrial transfer. At present, the world’s first 1,000-ton-scale solar fuel synthesis demonstration project in Lanzhou New District Green Chemical Industry Park has basically completed all technical indicators.
The so-called solar fuel synthesis refers to the use of renewable energy such as solar energy, wind energy and water energy to generate electricity and produce clean and renewable liquid fuels such as methanol, which is called "liquid sunlight", which is also considered as one of the fundamental ways to solve carbon dioxide emissions in the future, and is also a new energy storage technology to collect and store renewable energy such as intermittent solar energy.
The project consists of three basic units: solar photovoltaic power generation, hydrogen production by electrolysis of water and methanol synthesis by hydrogenation of carbon dioxide. The project relies on the transformation project of scientific and technological achievements of academician expert workstation established by Academician Li Can of Dalian Institute of Chemical Physics, Chinese Academy of Sciences, and uses photovoltaic power generation and electrolysis of new high-efficiency catalyst to prepare hydrogen, and then uses new high-efficiency catalyst to build kiloton carbon dioxide hydrogenation to synthesize methanol.
In January, 2021, under the guidance of Academician Li Can and the team of experts, the world’s first 1,000-ton-scale solar fuel synthesis demonstration project was successfully tested in the Green Chemical Industry Park of Lanzhou New District, producing crude methanol, which marked the first step of the project to transform renewable energy such as solar energy into liquid fuel for industrial production, and realized the industrialization demonstration from laboratory research results.
According to reports, the project is of great significance to alleviate the energy security problems in China and even the global ecological civilization construction. On the one hand, it explores the optimal utilization mode of abundant renewable energy such as solar energy in western China, and provides an effective path other than UHV transmission for converting renewable energy such as solar energy into liquid fuel methanol; On the other hand, solar fuel methanol is a green hydrogen carrier, which can help solve the safety problem of hydrogen energy storage and transportation.
Just like the "liquid sunshine" eco-energy project’s green conversion of energy, Lanzhou New District Chemical Industry Park has been committed to the research of green and fine chemicals, in order to look for energy solutions with good environment and sustainable development.
At present, it is located in the northwest of Lanzhou New District, about 25 kilometers away from the core area of the new district, with a total planned area of 150 square kilometers. The infrastructure of water, electricity, roads, gas, steam and communication in the first phase (12 square kilometers) of the Chemical Industry Park has been fully completed and put into use, which fully meets the construction and production conditions of the landing projects. The investment in fixed assets has been 21.5 billion yuan, and it is expected that 50 enterprises will be completed and put into operation by the end of the year, showing a strong development trend.
More than 160 projects have been introduced into the park, with a total investment of over 27 billion yuan and more than 700 kinds of landing products. Among them, the "Specialization and Innovation" Chemical Science and Technology Industrial Park plans to build 600 special workshops, 200 buildings will be opened and 75 buildings will be put into operation, so as to build an international exclusive demonstration zone and an export base for "production, learning and research" of high-end chemicals in integration of defense and civilian technologies. Among them, more than 60 products, such as liquid crystal display materials, anti-tumor pharmaceutical intermediates and third-generation cephalosporins, have reached the international advanced level, which can effectively alleviate the shortage of corresponding products in China.
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Verify the third-party measurement of ultra-quiet tire Goodyear Royal Ride

Imperial ride; Head figure

Foreword:
   In the last tire evaluation, we brought you the dry ground test of Bridgestone’s top running tire S001, which made you appreciate the strong performance of a top running tire. However, for ordinary car owners, in addition to the grip, the mute performance is also a key indicator for choosing tires. As early as the release of Imperial Ride at the end of July, we had already experienced the performance of Imperial Ride at Zhuhai Circuit, but it was only a short test drive and we could not fully understand the performance of Imperial Ride. In this tire test, we found four Goodyear royal tires, and we want to measure the performance and mute ability of this self-proclaimed quietest tire in history through professional instruments.

Related links about Yu Cheng:

Imperial ride
Imperial ride

Vehicles and environment tested:
    We borrowed a BMW 3 Series 318 E46, and its 2.0L natural inspiratory energy output is 105kw, which is 200Nm. The test site is a newly paved two-way two-lane asphalt pavement. The distance between piles and cylinders tested around piles is 18m. The noise test section is asphalt pavement with few vehicles.

60km/h test around piles:

Imperial ride; Around the pile

    The speed of entering the pile barrel area is 60km/h during the test around the pile. We use a special acceleration measuring instrument to measure the lateral acceleration of the vehicle around the pile to observe whether the tire slips and its maximum lateral grip.

Imperial ride; Around the pile

    From the data chart of lateral acceleration around the pile, we can see that the maximum acceleration that Goodyear Royal Ride can get when it is around the pile is 0.989G, and there is no lateral acceleration fluctuation when the curve peak area is seriously skidded. However, the lateral acceleration limit of an energy-saving tire of a certain brand is slightly lower, and the maximum acceleration can only reach 0.879G, and the lateral acceleration fluctuation caused by slipping appears in the peak area of the curve. Except for the old and new differences between the two sets of tires (the energy-saving tire of the original car has just been replaced for one month, and the tread thickness is far from reaching the wear limit; The Imperial Ride is a new tire), and the dry handling ability of the Imperial Ride is better than that of the energy-saving tire used for comparison.

Imperial ride; Shoulder; Softer

    In terms of driving experience, when we first got on the bus, we have noticed that the tire has a noticeable deformation with the increase of the load of the car. This is caused by the soft shoulder of the royal tire (see the picture above). We can clearly perceive this when we feel the hardness of the shoulder with our hands when the rim is not assembled. The softer shoulder allows the whole tire to deform to a certain extent to absorb the vibration, thus making the driver feel that the tire is softer and more comfortable when driving. We also tested the limit of the imperial car around the pile. The imperial car won’t slip when it doesn’t touch the limit area around the pile, but when it reaches the limit, it will slip immediately and grab the ground again in a short time (several hundred milliseconds). It feels a little longer from slipping to grabbing the ground again, which is easier to detect. Of course, the average car owner will not go around the pile like us, let alone find the limit point when going around the pile like us. The dry land performance of Yu Cheng is excellent for its positioning.

six0km/h acceleration and braking test:

Imperial ride; apply the brakes

    The 60km/h acceleration and braking test are combined, and we record the longitudinal acceleration, acceleration time and braking distance of the car body during the whole process. Accelerated Start We use the catapult start mode (this 3 Series E46 is an automatic gear), step on the brake and accelerate at full throttle. When the speed reaches 3000 rpm, release the brake and the vehicle will eject like a bullet. Some netizens questioned whether there was no such car. When we test, we step on the brake and accelerate at full throttle, and the speed will rise from 1000 rpm to 3000 rpm, and we can’t continue to increase it. This is obviously because the DSC dynamic stability system and DME management system limit the power output. We guess that BMW’s on-board computer has been able to identify this catapult starting mode and make some restrictions and optimizations.

Imperial ride; tyre

    There is no noticeable slip in both sets of tires, but there is still a difference in data. Goodyear Royal Ride can achieve 0.567G longitudinal acceleration at the beginning, while the energy-saving tires of the original car can only provide 0.455G acceleration. The test data of the energy-saving tires of the original car also showed that there was jitter in the peak acceleration area, which also proved that there was slippage at that time. In contrast, the imperial ride is better in longitudinal grip.
    In the emergency braking test data, we can see that both tires skidded to a certain extent during emergency braking. The maximum acceleration of the original set of tires was slightly higher than that of Imperial Ride for the first time, but Imperial Ride could get greater deceleration when it grasped the ground again after skidding. The maximum deceleration of the original energy-saving tire during emergency braking is 1.142G, while the maximum deceleration of the imperial vehicle is 1.264G g.

Imperial ride; test

    Because of its higher longitudinal grip performance, the acceleration time and braking distance of the royal ride are faster, but the difference is not obvious.

60-80km/h noise test:

Imperial ride

    We use a noise meter to measure the tire noise when the vehicle is running at a speed of 60-80 km/h. As can be seen from the overlay below, the dark noise curve of Royal Ride is lower than that of another set of energy-saving tires, which is about 1-2 decibels lower on average. Considering the road conditions, we didn’t conduct a higher-speed noise test. What is the effect of noise reduction level of 1-2 decibels? We can explain here that if there is a noise reduction of 3 decibels, people can clearly distinguish the difference in noise volume, so a noise reduction of 1-2 decibels can be perceived. Of course, the higher the speed, the more obvious the difference in noise reduction performance of tires. Soft tread and shoulder also "enhance" the noise reduction effect of Yu Cheng from the driving experience.

Imperial ride

Temperature hardness test before and after test:

Imperial ride Imperial ride

Imperial ride; Temperature; hardness

    We have also tested the temperature and hardness of different tires before. In contrast, the tread material of Yuchai is soft, and the temperature rise of the tire is low after the test. Soft tread has better comfort, while less temperature rise enhances its energy-saving effect. We are satisfied with the temperature rise and ride comfort of the Royal Tire before and after the test. Royal ride is quite competent as a comfortable and energy-saving tire.

More test pictures:

Imperial ride; Tires; Testing; BMW; E46 32455345
Imperial ride; Tires; Testing; BMW; E46 Imperial ride; Tires; Testing; BMW; E46
Imperial ride; Tires; Testing; BMW; E46 Imperial ride; Tires; Testing; BMW; E46

More related links:
Experience the Top Performance Bridgestone S001 Third Party Testing
Tire replacement instructions and tire selection guide

Summary:
   As a comfortable and energy-saving tire, Imperial Ride has done a good job in comfort and energy saving, and at the same time, it has a good performance in handling. For those of us who have just finished testing a sports tire, we can better understand the comfort of riding. Compared with the comfortable and energy-saving tires of the same grade, Imperial Ride has better handling performance. In terms of cost performance, the market price of Royal Ride is competitive. For those users who are dissatisfied with the noise and comfort of the original tires, Goodyear Royal Ride is a good choice.

Return peak! Congestion warning


National DayThe Mid-Autumn Festival holiday has come to an end.

Return trip is just around the corner

Yichang traffic police issued travel tips

Plan the route in advance to avoid congestion.

Return safely and comfortably.


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Easy blocking period


The peak return period of the National Day holiday appeared inOn October 7, October 8, from 9: 00 to 12: 00, from 15: 00 to 17: 00, and from 19: 00 to 21: 00,estimateAround yichang east railway stationChengcheng intersection, Baisha intersection and Tongqiang intersection of Chengdong AvenueThere is a large traffic flow on equal sections. If the citizens have no plans to go out to the East Station,It is suggested to avoid the road sections around the East Station and reduce the travel pressure around the East Station.


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Easy-to-block section in and out of the city


The Zhongnan Road section of Chengdong Avenue and Yiling Avenue (Jinlong Road to Wangjiahe Section) are the main access roads to and from the urban area. The residential and commercial areas along the line are relatively concentrated, and the daily commuting flow is relatively large. The holiday coincides with the construction of the Wujiagang District (Yiling Avenue section) of Yichang-Fuyang Railway, which is affected by the construction.Part of the road lanes in this section are occupied, leaving only one lane in both directions for vehicles to pass., there are traffic limitations.


During the return trip, withThe traffic flow in and out of the city is superimposed with the traffic of surrounding residents, so the construction section can’t bear pressure, and there is trafficThe bottleneck leads to the slow speed, low traffic efficiency, slow traffic queue and easy vehicle detention.


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Easy-to-block section around passenger station


After the National Day holiday, during the return journey, the passenger flow and traffic flow in yichang east railway station, coach station and Three Gorges Airport will show an upward trend, and the traffic flow will slow down in the surrounding sections.

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Early warning of main roads, bridges and high-speed entrances and exits


During the return journey, the traffic volume of Xiling No.2 Expressway (underground passage), Shanghai-Chongqing Expressway (Yichang Toll Station and Qiaobei Toll Station), Shanghai-Chengdu Expressway (Yichang North Toll Station and Yaqueling Toll Station) and other sections and high-speed entrances and exits will show an upward trend, and there will be more cars slowing down and the exit may be stranded for a long time, which should be paid special attention to!


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Yichang meteorological forecast

Today (7th) to 8th.

Cloudy and alone

There may be some short-term light rain in some areas.

Some sections are foggy in the morning.

Drivers, please slow down.

caution

Hubei traffic policeestimate

These during the return trip

Service areas, toll stations and expressway sections

The traffic volume is large.

Dear drivers and friends,

Navigation can be used to plan driving routes reasonably.

Staggered peak and traffic avoidance


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Congestion prone road section



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Congestion-prone service area



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Easy congestion toll gate



b3133b957e74462b49bf45de5f13d498.png


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Busy charging service area



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Passenger vehicles with less than 7 seats (including 7 seats) on the National Day holiday expressway.The free passage time will end at 24: 00 on October 8., subject to the time when the vehicle leaves the exit of the toll station.


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Warm reminder:Vehicles that are still driving on the expressway before the end of the free time period are advised to choose the nearest toll station to leave the expressway according to the actual location and time, so as to avoid safety accidents caused by rushing and speeding, and at the same time enjoy the free policy to the maximum extent.


Don’t worry about the return trip

Please keep these safety reminders in mind!


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Check the condition of the car and put an end to hidden dangers

Check tires (tire pressure, wear and tear), brakes, lights and oil (engine oil, coolant and glass water) before departure to ensure that the vehicle is in good condition.


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2

Refuse to drive fatigue.

Drive continuously for no more than 4 hours, and stop for no less than 20 minutes. If you feel sleepy and inattentive, please go to the nearest service area immediately or leave the expressway to rest.


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three

Keep a safe distance.

Keep a safe distance from the vehicle in front, and reserve sufficient reaction time to avoid rear-end collision.


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four

Observe the speed limit and drive smoothly.

Don’t drive too fast and don’t occupy the road at low speed. In case of congestion, queue patiently, and it is forbidden to occupy the emergency lane.


05


In case of emergency

Keep in mind "Call the police when the car pulls over and people evacuate."Nine words tactic. If the vehicle can move, quickly move to the emergency lane; Turn on the double flash, and place a triangle warning sign 150 meters behind the car; All personnel should evacuate to the safety zone outside the guardrail and then call the police.027-96122or12122.

Xiao bu reminds

Whether you are returning or still on the journey.

We should put safety first.

Pay attention to road information in advance

Drive safely and return safely.


Zero car: 20,100 delivered in June

Beijing News Shell Financial News (Reporter Zhang Bing) July 1, according to the latest data released by Zero Run Car, in June 2024, Zero Run Car delivered 20116 units, an increase of 52.3% year-on-year. Previously on June 28, six-seat SUV Zero Run C16 was listed, priced 155,800 yuan – 185,800 yuan. Zero Run Car said that the new car will reach 5208 units within 48 hours of listing.

Editor, Qin Che

Proofreading, Yang Li

World Intellectual Property Day | ""is a network term? Do you know these signs?

""is a network term?

""is a variety show logo?

""is a whitening VC?

In daily life

We can often see these symbols.

But do you know what they represent?

【™】? Internet language?

In fact, what we often see is the abbreviation of "TradeMark", which is the trademark.

Trademarks include registered trademarks and unregistered trademarks that are directly used but not approved by the Trademark Office.

Among them, unregistered trademarks can only be protected by law to a certain extent if they reach a certain popularity.

[] Basketball team logo? Variety show logo?

When you see a package marked with "",this is the abbreviation of registered trademark "Register", which means that this trademark is a registered trademark and is protected by relevant laws.

Koko added

Logo≠ trademark, they are different.

LOGO is only a visual identification sign, and a trademark can clearly indicate the source of goods or services besides identification. Specifically, LOGO doesn’t need to be used in a certain industry or product. As long as you have applied for copyright protection, once others copy it, you can defend your rights no matter how far the industry is from you. The trademark must clearly specify which products are used, such as 25 kinds of clothing, shoes and hats. If other products, such as 20 kinds of furniture products, use the same trademark name, it does not constitute infringement.

Difference 1: the way to confirm the right is different

Logo, as an art work, does not need to be registered, and the copyright is automatically obtained when the creation is completed, while the trademark must be registered by the corresponding state authorities to obtain the trademark right.

Difference 2: different ownership of rights

The designer and owner of logo are probably not the same person. Ordinary companies have to entrust designers to design logo. As a commissioned works, the copyright of Logo belongs to the client in two cases, or it belongs to the designer if there is no agreement, and the trademark belongs to the trademark owner only. This is the category of intellectual property rights.

Difference 3: The laws of protection are different.

Logo is protected by Copyright Law and trademark is protected by Trademark Law. Logo can be registered as a trademark, so this trademark logo is protected by both the Copyright Law and the Trademark Law, which means that the protection scope of logo and trademark is different, and the protection scope of logo is not as wide as that of trademark. If the intensity of infringement protection is different, of course, the protection of trademarks is greater than that of copyright. If the copyright of the logo belongs to the designer, then if the logo is infringed, it actually harms the interests of the logo owner, but only the designer has the right to sue. The trademark owner can directly sue the infringement in his own name.

Difference 4: The duration of protection is different.

Logo as a work of art is generally protected for 50 years, while trademarks can be extended indefinitely, and the time of protection is unlimited.

[PATENT] Do you know this word?

The English word for patent is "patent". In China, patents are divided into three types: invention, utility model and design.

Generally speaking, the more patents granted, the stronger the core competition of an enterprise.

Koko added

Note that these are not patented.

No patent right shall be granted for inventions and creations that violate laws, social ethics or hinder public interests.

No patent right shall be granted to inventions and creations that are obtained or utilized in violation of the provisions of laws and administrative regulations and are completed by relying on the genetic resources.

-Article 5 of the Patent Law of People’s Republic of China (PRC)

No patent right shall be granted for the following items:

(1) scientific discoveries;

(2) Rules and methods of intellectual activities;

(3) Methods of diagnosis and treatment of diseases;

(4) Species of animals and plants;

(5) Nuclear transformation methods and substances obtained by nuclear transformation methods;

(six) the design of the pattern, color or the combination of the two of the plane printed matter.

-Article 25 of the Patent Law of People’s Republic of China (PRC)

【©】? Whitening VC?

""stands for "copyright", which can be divided into "work copyright" and "software copyright".

"Software copyright" mainly maintains the source code of the software. A song, a movie and a TV play all enjoy the copyright of the works.

"Copyright" does not require compulsory registration. Once the work is completed, the author enjoys the copyright regardless of whether it is published or not. The registration of works is voluntary, and the copyright owner can decide whether to go through the copyright registration formalities.

Koko added

These works are protected by law.

(1) written works;

(2) oral works;

(3) works of music, drama, folk art, dance and acrobatics;

(4) Art and architectural works;

(5) Photographic works;

(6) cinematographic works and works created by methods similar to cinematography;

(7) Graphic works and model works such as engineering design drawings, product design drawings, maps and schematic diagrams;

(8) computer software;

(9) Other works as prescribed by laws and administrative regulations.

These works are not protected by law.

Works not protected by copyright law or not applicable to copyright law include:

(1) works whose publication and dissemination are prohibited according to law;

(2) Laws and regulations, resolutions, decisions and orders of state organs and other documents of a legislative, administrative and judicial nature, and their official translations;

(3) current affairs news;

(4) Calendar, general tables, general tables and formulas.

These four symbols are derived

The most common "intellectual property" around us.

But the content covered by "intellectual property rights"

But it is far more than that.

There are also geographical indications and new plant varieties.

Trade secrets, integrated circuit layout design, etc.

In essence, intellectual property is an intangible property right, and its object is intellectual achievements or knowledge products, an intangible property or a spiritual wealth without form, and a labor result created by creative intellectual labor.

Like tangible property such as houses and cars, it is protected by national laws and has value and use value. The value of some major patents, well-known trademarks or works is far higher than that of tangible property such as houses and automobiles.

Its object has four characteristics: immateriality (my material achievements can be taken away, but my wisdom can’t be seen or touched by others), specific exclusivity (mine is mine, and others can’t take it), timeliness (remember to renew the fee when the time comes) and regionality (protected here, not necessarily elsewhere).

It is closely related to everyone’s life. Whether we open a book, listen to a piece of music, hold a mobile phone or even brush a short video on the mobile phone, there are intellectual property rights everywhere. Protecting intellectual property rights and intellectual labor results can better mobilize the enthusiasm of knowledge innovators, thus promoting economic development and scientific and technological progress.

Let’s join hands to jointly protect and respect intellectual property rights and create a good atmosphere for creating a new situation of building a strong intellectual property country.

Original title: "World Intellectual Property Day |" is a network term? Do you know these signs? 》

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